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Oral Communications
* Presenting Author
Chairpersons: James Douketis (CA) and Gregor Hron (AT)
OC-TH-001
8:00 AM - 8:15 AM
INCREASING LEVELS OF THROMBIN GENERATION PRECEDE RECURRENT DVT
A. J. ten Cate-Hoek* (NL), A. J. W. H. Dielis, H. M. H. Spronk, R. van Oerle, K. Hamulyák, M. H. Prins, H. ten Cate
8:00 AM - 8:15 AM
INCREASING LEVELS OF THROMBIN GENERATION PRECEDE RECURRENT DVT
A. J. ten Cate-Hoek* (NL), A. J. W. H. Dielis, H. M. H. Spronk, R. van Oerle, K. Hamulyák, M. H. Prins, H. ten Cate
OC-TH-002
8:15 AM - 8:30 AM
D-DIMER TO PREDICT THROMBOSIS RECURRENCE AFTER UNPROVOKED VENOUS THROMBOEMBOLISM: EFFECT OF PATIENTAND D-DIMER-RELATED FACTORS ON RECURRENCE PREDICTION
A. Iorio* (IT), J. Douketis, M. Marcucci, T. Baglin, M. Cushman, S. Eichinger, G. Palareti, D. Poli, C. Tait, A. Tosetto
8:15 AM - 8:30 AM
D-DIMER TO PREDICT THROMBOSIS RECURRENCE AFTER UNPROVOKED VENOUS THROMBOEMBOLISM: EFFECT OF PATIENTAND D-DIMER-RELATED FACTORS ON RECURRENCE PREDICTION
A. Iorio* (IT), J. Douketis, M. Marcucci, T. Baglin, M. Cushman, S. Eichinger, G. Palareti, D. Poli, C. Tait, A. Tosetto
OC-TH-003
8:30 AM - 8:45 AM
D-DIMER TIME COURSE AFTER STOPPING ANTICOAGULATION AFTER A FIRST EPISODE OF IDIOPATHIC VENOUS THROMBOEMBOLISM: THE PROLONG II PROSPECTIVE STUDY
B. Cosmi* (IT), C. Legnani, A. Tosetto, V. Pengo, A. Ghirarduzzi, A. Alatri, S. Testa, D. Prisco, D. Poli, A. Tripodi, G. Palareti
8:30 AM - 8:45 AM
D-DIMER TIME COURSE AFTER STOPPING ANTICOAGULATION AFTER A FIRST EPISODE OF IDIOPATHIC VENOUS THROMBOEMBOLISM: THE PROLONG II PROSPECTIVE STUDY
B. Cosmi* (IT), C. Legnani, A. Tosetto, V. Pengo, A. Ghirarduzzi, A. Alatri, S. Testa, D. Prisco, D. Poli, A. Tripodi, G. Palareti
OC-TH-004
8:45 AM - 9:00 AM
CLINICAL PREDICTION GUIDE TO PREDICT THROMBOSIS RECURRENCE AFTER A FIRST UNPROVOKED VENOUS THROMBOEMBOLISM
A. Tosetto* (IT), A. Iorio, M. Marcucci, T. Baglin, M. Cushman, S. Eichinger, G. Palareti, D. Poli, C. Tait, J. Douketis
8:45 AM - 9:00 AM
CLINICAL PREDICTION GUIDE TO PREDICT THROMBOSIS RECURRENCE AFTER A FIRST UNPROVOKED VENOUS THROMBOEMBOLISM
A. Tosetto* (IT), A. Iorio, M. Marcucci, T. Baglin, M. Cushman, S. Eichinger, G. Palareti, D. Poli, C. Tait, J. Douketis
OC-TH-005
9:00 AM - 9:15 AM
RISK FACTOR FOR THE PREDICTION OF RECURRENT VENOUS THROMBOEMBOLISM
J. Emmerich* (FR), T. Zhu, L. Carcaillon, I. Martinez, V. Olie, V. Remones, F. Dali-Ali, P. Scarabin
9:00 AM - 9:15 AM
RISK FACTOR FOR THE PREDICTION OF RECURRENT VENOUS THROMBOEMBOLISM
J. Emmerich* (FR), T. Zhu, L. Carcaillon, I. Martinez, V. Olie, V. Remones, F. Dali-Ali, P. Scarabin
OC-TH-006
9:15 AM - 9:30 AM
D-DIMER AND COMORBIDITIES AS RISK FACTORS FOR RECURRENCE AFTER A FIRST EPISODE OF VENOUS THROMBOEMBOLISM IN THE EXTENDED FOLLOW-UP OF THE PROLONG STUDY
B. Cosmi* (IT), C. Legnani, V. Pengo, A. Ghirarduzzi, S. Testa, A. Alatri, D. Prisco, D. Poli, A. Tripodi, G. Palareti
Chairpersons: Samuel Goldhaber (US) and Walter Ageno (IT)
9:15 AM - 9:30 AM
D-DIMER AND COMORBIDITIES AS RISK FACTORS FOR RECURRENCE AFTER A FIRST EPISODE OF VENOUS THROMBOEMBOLISM IN THE EXTENDED FOLLOW-UP OF THE PROLONG STUDY
B. Cosmi* (IT), C. Legnani, V. Pengo, A. Ghirarduzzi, S. Testa, A. Alatri, D. Prisco, D. Poli, A. Tripodi, G. Palareti
Chairpersons: Samuel Goldhaber (US) and Walter Ageno (IT)
OC-TH-007
8:00 AM - 8:15 AM
SINGLE-DOSE ADJUSTMENT VERSUS NO ADJUSTMENT OF WARFARIN IN STABLY ANTICOAGULATED PATIENTS WITH AN OCCASIONAL LEVEL OUT OF RANGE
S. Schulman* (CA), A. Melinyshyn, D. Ennis, L. Rudd-Scott
8:00 AM - 8:15 AM
SINGLE-DOSE ADJUSTMENT VERSUS NO ADJUSTMENT OF WARFARIN IN STABLY ANTICOAGULATED PATIENTS WITH AN OCCASIONAL LEVEL OUT OF RANGE
S. Schulman* (CA), A. Melinyshyn, D. Ennis, L. Rudd-Scott
OC-TH-008
8:15 AM - 8:30 AM
FREQUENCY OF MAJOR BLEEDING IN PATIENTS TREATED WITH LOW MOLECULAR WEIGHT HEPARIN FOR DEEP-VEIN THROMBOSIS OR PULMONARY EMBOLISM- A STUDY IN ROUTINE CLINICAL PRACTICE
M. Zidane* (NL), E. P. C. Plompen, F. Cluitmans, F. J. M. van der Meer, E. V. Planken, M. V. Huisman
8:15 AM - 8:30 AM
FREQUENCY OF MAJOR BLEEDING IN PATIENTS TREATED WITH LOW MOLECULAR WEIGHT HEPARIN FOR DEEP-VEIN THROMBOSIS OR PULMONARY EMBOLISM- A STUDY IN ROUTINE CLINICAL PRACTICE
M. Zidane* (NL), E. P. C. Plompen, F. Cluitmans, F. J. M. van der Meer, E. V. Planken, M. V. Huisman
OC-TH-009
8:30 AM - 8:45 AM
LOW-INTENSITY ADJUSTED-DOSE WARFARIN FOR THE PREVENTION OF MECHANICAL MALFUNCTION OF DOUBLE-LUMEN HAEMODIALYSIS CATHETERS: A RANDOMIZED CONTROLLED TRIAL
C. M. Clase, M. A. Crowther* (CA), T. J. Wilkieson, S. D. Soroka, R. Nagai, K. K. Jindal, A. J. Ingram
8:30 AM - 8:45 AM
LOW-INTENSITY ADJUSTED-DOSE WARFARIN FOR THE PREVENTION OF MECHANICAL MALFUNCTION OF DOUBLE-LUMEN HAEMODIALYSIS CATHETERS: A RANDOMIZED CONTROLLED TRIAL
C. M. Clase, M. A. Crowther* (CA), T. J. Wilkieson, S. D. Soroka, R. Nagai, K. K. Jindal, A. J. Ingram
OC-TH-010
8:45 AM - 9:00 AM
BLEEDING RISK WITH FIXED DOSE SUBCUTANEOUS LOW MOLECULAR WEIGHT HEPARIN COMPARED TO INTRAVENOUS ADJUSTED DOSE UNFRACTIONATED HEPARIN: A METANALYSIS
G. Podda* (IT), G. Costantino, E. Ceriani, A. Rusconi, G. Casazza, N. Montano, P. Duca, M. Cattaneo
8:45 AM - 9:00 AM
BLEEDING RISK WITH FIXED DOSE SUBCUTANEOUS LOW MOLECULAR WEIGHT HEPARIN COMPARED TO INTRAVENOUS ADJUSTED DOSE UNFRACTIONATED HEPARIN: A METANALYSIS
G. Podda* (IT), G. Costantino, E. Ceriani, A. Rusconi, G. Casazza, N. Montano, P. Duca, M. Cattaneo
OC-TH-011
9:00 AM - 9:15 AM
LMWH VS ASPIRIN FOR THE TREATMENT OF ACUTE RETINAL VEIN OCCLUSION
W. Ageno* (IT), R. Cattaneo, E. Manfredi, A. Ghirarduzzi, E. Filippucci, G. Scannapieco, F. Rubbi, D. Imberti
9:00 AM - 9:15 AM
LMWH VS ASPIRIN FOR THE TREATMENT OF ACUTE RETINAL VEIN OCCLUSION
W. Ageno* (IT), R. Cattaneo, E. Manfredi, A. Ghirarduzzi, E. Filippucci, G. Scannapieco, F. Rubbi, D. Imberti
OC-TH-012 9:15
AM - 9:30 AM
PREDICTION OF THE WARFARIN MAINTENANCE DOSE AFTER COMPLETION OF THE 10 MG INITIATION NOMOGRAM
G. Le Gal* (FR), M. Carrier, S. Tierney, H. Majeed, M. Rodger, P. S. Wells
Chairperson: Alex Spyropoulos (US), Cecilia Becattini (IT)
OC-TH-013
8:00 AM - 8:15 AM
THE ROLE OF NEW EDUCATIONAL MATERIAL IN PATIENTS KNOWLEDGE OF ANTICOAGULANT THERAPY
N. Ostasevski Fernandez* (SI), A. Kramaric, A. Mavri
OC-TH-014
8:15 AM - 8:30 AM
AM - 9:30 AM
PREDICTION OF THE WARFARIN MAINTENANCE DOSE AFTER COMPLETION OF THE 10 MG INITIATION NOMOGRAM
G. Le Gal* (FR), M. Carrier, S. Tierney, H. Majeed, M. Rodger, P. S. Wells
Chairperson: Alex Spyropoulos (US), Cecilia Becattini (IT) OC-TH-013
8:00 AM - 8:15 AM
THE ROLE OF NEW EDUCATIONAL MATERIAL IN PATIENTS KNOWLEDGE OF ANTICOAGULANT THERAPY
N. Ostasevski Fernandez* (SI), A. Kramaric, A. Mavri
OC-TH-014
8:15 AM - 8:30 AM
MULTIDETECTOR COMPUTED TOMOGRAPHY TO ASSESS CLINICAL OUTCOME IN HEMODYNAMICALLY STABLE PATIENTS WITH ACUTE PULMONARY EMBOLISM
C. Becattini* (IT), M. C. Vedovati, S. Grifoni, F. Casazza, R. Douma,
M. Bianchi, A. Salvi, S. Konstantinides, S. Vanni, W. Ageno, P. Kamphuisen,
C. Nitti, R. Poggio, M. Duranti, G. Agnelli
OC-TH-016
8:30 AM - 8:45 AM
VENOUS THROMBOEMBOLISM PHARMACY INTERVENTION MANAGEMENT PROGRAM
C. E. Mahan* (US), M. A. Hussein, A. N. Amin, A. C. Spyropoulos
OC-TH-017
8:45 AM - 9:00 AM
COST-EFFECTIVENESS OF RULING OUT DEEP VENOUS THROMBOSIS (DVT) IN PRIMARY CARE
A. J. ten Cate-Hoek* (NL), H. E. J. H. Stoffers, E. van der Velde, H. C. van Weert, D. B. Toll, H. R. Büller, A. W. Hoes, K. G. M. Moons, R. Oudega, M. H. Prins, M. Joore
OC-TH-018
9:00 AM - 9:15 AM
EFFECT OF A COMPUTERIZED HANDHELD CLINICAL DECISION SUPPORT SYSTEM ON THE APPROPRIATENESS OF PULMONARY EMBOLISM DIAGNOSIS IN EMERGENCY DEPARTMENTS. A CLUSTER CONTROLLED CLINICAL TRIAL
P. Roy* (FR), P. Durieux, F. Guillaizeau, C. Legall, A. Armand-Perroux, L. Martino, M. Hachelaf, A. Dubart, J. Schmidt, M. Cristiano, J. Chretien, A. Perrier, G. Meyer
Chairpersons: Raj Kasthuri (IN) and Christilla Bachelot-Loza (FR)
OC-TH-019
8:00 AM - 8:15 AM
A HIGHER PREVALENCE OF HIT ANTIBODIES IN HEMODIALYSIS PATIENTS MAY BE DUE TO CONTAMINATED HEPARIN
J. M. Walenga* (US), D. Hoppensteadt, J. Cunanan, C. Adiguzel, O. Iqbal, J. Fareed
8:00 AM - 8:15 AM
A HIGHER PREVALENCE OF HIT ANTIBODIES IN HEMODIALYSIS PATIENTS MAY BE DUE TO CONTAMINATED HEPARIN
J. M. Walenga* (US), D. Hoppensteadt, J. Cunanan, C. Adiguzel, O. Iqbal, J. Fareed
OC-TH-020
8:15 AM - 8:30 AM
HEPARIN ANTIBODY COMPLEXES ACTIVATE MONOCYTES AND INDUCE THE RELEASE OF TISSUE FACTOR POSITIVE MICROPARTICLES
R. S. Kasthuri* (US), S. Glover, G. Arepally, N. Key, N. Mackman
8:15 AM - 8:30 AM
HEPARIN ANTIBODY COMPLEXES ACTIVATE MONOCYTES AND INDUCE THE RELEASE OF TISSUE FACTOR POSITIVE MICROPARTICLES
R. S. Kasthuri* (US), S. Glover, G. Arepally, N. Key, N. Mackman
OC-TH-021
8:30 AM - 8:45 AM
THROMBIN GENERATION RELATED TO HEPARIN-INDUCED THROMBOCYTOPENIA
B. Tardy- Poncet* (FR), M. Piot, C. Chapelle, L. Campos, O. Garraud, H. Decousus, P. Mismetti, B. Tardy
8:30 AM - 8:45 AM
THROMBIN GENERATION RELATED TO HEPARIN-INDUCED THROMBOCYTOPENIA
B. Tardy- Poncet* (FR), M. Piot, C. Chapelle, L. Campos, O. Garraud, H. Decousus, P. Mismetti, B. Tardy
OC-TH-022
8:45 AM - 9:00 AM
THE RISK OF HEPARIN-INDUCED THROMBOCYTOPENIA IS INCREASED IN PATIENTS HOMOZYGOUS FOR THE GNB3 825T ALLELE
E. Boissier* (FR), D. Lasne, C. Pouplard, S. Gandrille, M. Alhenc-Gelas, F. Grelac, P. Gaussem, Y. Gruel, C. Bachelot-Loza
8:45 AM - 9:00 AM
THE RISK OF HEPARIN-INDUCED THROMBOCYTOPENIA IS INCREASED IN PATIENTS HOMOZYGOUS FOR THE GNB3 825T ALLELE
E. Boissier* (FR), D. Lasne, C. Pouplard, S. Gandrille, M. Alhenc-Gelas, F. Grelac, P. Gaussem, Y. Gruel, C. Bachelot-Loza
OC-TH-023
9:00 AM - 9:15 AM
ANTIBODIES OF PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA RECOGNIZE COMPLEXES FORMED BY PLATELET FACTOR 4 AND NUCLEIC ACIDS
M. E. Jaax* (DE), K. Krauel, B. Fürll, T. Marschall, B. Appel, S. Müller, S. Fischer, K. T. Preissner, A. Greinacher
9:00 AM - 9:15 AM
ANTIBODIES OF PATIENTS WITH HEPARIN-INDUCED THROMBOCYTOPENIA RECOGNIZE COMPLEXES FORMED BY PLATELET FACTOR 4 AND NUCLEIC ACIDS
M. E. Jaax* (DE), K. Krauel, B. Fürll, T. Marschall, B. Appel, S. Müller, S. Fischer, K. T. Preissner, A. Greinacher
OC-TH-024
9:15 AM - 9:30 AM
IMPROVING THE CAPABILITY OF THE ANTI-PF4/HEPARIN ENZYME IMMUNOSORBENT ASSAY TO RULE OUT PLATELET ACTIVATING PF4/HEPARIN ANTIBODIES
K. Althaus* (DE), U. Strobel, B. Fuerll, A. Greinacher
Chairpersons: Hugo Ten Cate (NL) and Veikko Salomaa (FI)
OC-TH-025
8:00 AM - 8:15 AM
HIGH PLATELET REACTIVITY AND THE RISK OF MYOCARDIAL INFARCTION IN YOUNG WOMEN
J. D. Snoep* (NL), M. Roest, A. Barendrecht, F. R. Rosendaal, J. G. van der Bom
OC-TH-026
8:15 AM - 8:30 AM
HEREDITARY DEFICIENCY OF NATURAL INHIBITORS OF COAGULATION( ANTITROMBIN, PROTEIN C OR PROTEIN S) CONFERS INCREASED RISK OF ARTERIAL THROMBOEMBOLIC EVENTS. RESULTS FROM A PROSPECTIVE FAMILY COHORT STUDY
D. Tormene* (IT), M. Perlati, V. Ferri, M. Facchin, S. Gavasso, P. Simioni
9:15 AM - 9:30 AM
IMPROVING THE CAPABILITY OF THE ANTI-PF4/HEPARIN ENZYME IMMUNOSORBENT ASSAY TO RULE OUT PLATELET ACTIVATING PF4/HEPARIN ANTIBODIES
K. Althaus* (DE), U. Strobel, B. Fuerll, A. Greinacher
Chairpersons: Hugo Ten Cate (NL) and Veikko Salomaa (FI)
OC-TH-025
8:00 AM - 8:15 AM
HIGH PLATELET REACTIVITY AND THE RISK OF MYOCARDIAL INFARCTION IN YOUNG WOMEN
J. D. Snoep* (NL), M. Roest, A. Barendrecht, F. R. Rosendaal, J. G. van der Bom
OC-TH-026
8:15 AM - 8:30 AM
HEREDITARY DEFICIENCY OF NATURAL INHIBITORS OF COAGULATION( ANTITROMBIN, PROTEIN C OR PROTEIN S) CONFERS INCREASED RISK OF ARTERIAL THROMBOEMBOLIC EVENTS. RESULTS FROM A PROSPECTIVE FAMILY COHORT STUDY
D. Tormene* (IT), M. Perlati, V. Ferri, M. Facchin, S. Gavasso, P. Simioni
OC-TH-027
8:30 AM - 8:45 AM
ANTITHROMBIN CAMBRIDGE II (A384S) SUPPORTS A ROLE FOR ANTITHROMBIN DEFICIENCY IN ARTERIAL THROMBOSIS
V. Roldán, A. Ordóñez, F. Marín, E. Zorio, J. M. Soria, A. Miñano, F. España, R. González-Conejero, J. Pineda, A. Estellés, J. Fontcuberta, V. Vicente, J. Corral* (ES)
8:30 AM - 8:45 AM
ANTITHROMBIN CAMBRIDGE II (A384S) SUPPORTS A ROLE FOR ANTITHROMBIN DEFICIENCY IN ARTERIAL THROMBOSIS
V. Roldán, A. Ordóñez, F. Marín, E. Zorio, J. M. Soria, A. Miñano, F. España, R. González-Conejero, J. Pineda, A. Estellés, J. Fontcuberta, V. Vicente, J. Corral* (ES)
OC-TH-028
8:45 AM - 9:00 AM
A COMMON POLYMORPHISM IN LOW-DENSITY LIPOPROTEIN RECEPTOR GENE IS A PREDICTOR OF FACTOR VIII ACTIVITY LEVELS AND IS ASSOCIATED WITH CORONARY ARTERY DISEASE
N. Martinelli* (IT), B. Lunghi, D. Girelli, M. Pinotti, G. Marchetti, M. Bisi, O. Olivieri, F. Manzato, R. Corrocher, F. Bernardi
8:45 AM - 9:00 AM
A COMMON POLYMORPHISM IN LOW-DENSITY LIPOPROTEIN RECEPTOR GENE IS A PREDICTOR OF FACTOR VIII ACTIVITY LEVELS AND IS ASSOCIATED WITH CORONARY ARTERY DISEASE
N. Martinelli* (IT), B. Lunghi, D. Girelli, M. Pinotti, G. Marchetti, M. Bisi, O. Olivieri, F. Manzato, R. Corrocher, F. Bernardi
OC-TH-029
9:00 AM - 9:15 AM
VARIATION IN THE VON WILLEBRAND FACTOR GENE IS ASSOCIATED WITH THE RISK OF CARDIOVASCULAR DISEASES AT YOUNG AGE: A HAPLOTYPE APPROACH
M. C. van Schie* (NL), J. E. van Loon, D. W. J. Dippel, J. W. Deckers, D. D. Poldermans, M. P. M. de Maat, F. W. G. Leebeek
9:00 AM - 9:15 AM
VARIATION IN THE VON WILLEBRAND FACTOR GENE IS ASSOCIATED WITH THE RISK OF CARDIOVASCULAR DISEASES AT YOUNG AGE: A HAPLOTYPE APPROACH
M. C. van Schie* (NL), J. E. van Loon, D. W. J. Dippel, J. W. Deckers, D. D. Poldermans, M. P. M. de Maat, F. W. G. Leebeek
OC-TH-030
9:15 AM - 9:30 AM
HIGH PLASMA APOLIPOPROTEIN C-III LEVELS PREDICT TOTAL AND CARDIOVASCULAR MORTALITY IN PATIENTS WITH ANGIOGRAPHICALLY DEFINED CORONARY ARTERY DISEASE
N. Martinelli* (IT), D. Girelli, S. Friso, F. Pizzolo, P. Guarini, A. Bassi, G. Guidi, R. Corrocher, O. Olivieri
Chairpersons: Beatrice Hechler (FR) and Pieter Rietsma (NL)
9:15 AM - 9:30 AM
HIGH PLASMA APOLIPOPROTEIN C-III LEVELS PREDICT TOTAL AND CARDIOVASCULAR MORTALITY IN PATIENTS WITH ANGIOGRAPHICALLY DEFINED CORONARY ARTERY DISEASE
N. Martinelli* (IT), D. Girelli, S. Friso, F. Pizzolo, P. Guarini, A. Bassi, G. Guidi, R. Corrocher, O. Olivieri
Chairpersons: Beatrice Hechler (FR) and Pieter Rietsma (NL)
OC-TH-031
8:00 AM - 8:15 AM
EFFICACY OF FULL-LENGTH RECOMBINANT HUMAN PLASMIN IN A PORCINE MODEL OF ARTERIOVENOUS GRAFT THROMBOSIS
I. Hoefer, E. S. G. Stroes, G. Pasterkamp, M. Levi, J. A. Reekers, H. J. M. Verhagen, J. C. Meijers, J. E. Humphries* (US), J. I. Rotmans
8:00 AM - 8:15 AM
EFFICACY OF FULL-LENGTH RECOMBINANT HUMAN PLASMIN IN A PORCINE MODEL OF ARTERIOVENOUS GRAFT THROMBOSIS
I. Hoefer, E. S. G. Stroes, G. Pasterkamp, M. Levi, J. A. Reekers, H. J. M. Verhagen, J. C. Meijers, J. E. Humphries* (US), J. I. Rotmans
OC-TH-032
8:15 AM - 8:30 AM
BLOOD CELL-DERIVED MATRIX METALLOPROTEINASE TYPE 2 (MMP-2) PLAYS A ROLE IN ATHEROGENESIS
S. Momi* (IT), S. Giannini, P. Gresele
8:15 AM - 8:30 AM
BLOOD CELL-DERIVED MATRIX METALLOPROTEINASE TYPE 2 (MMP-2) PLAYS A ROLE IN ATHEROGENESIS
S. Momi* (IT), S. Giannini, P. Gresele
OC-TH-033
8:30 AM - 8:45 AM
£ LOCALIZED ARTERIAL THROMBOSIS ON RUPTURED ATHEROSCLEROTIC PLAQUES OF APOE-/- MICE AFTER VASCULAR INJURY WITH ULTRASOUND
B. Hechler* (FR), A. Eckly, S. Magnenat, M. Freund, J. P. Cazenave, F. Lanza, C. Gachet
8:30 AM - 8:45 AM
£ LOCALIZED ARTERIAL THROMBOSIS ON RUPTURED ATHEROSCLEROTIC PLAQUES OF APOE-/- MICE AFTER VASCULAR INJURY WITH ULTRASOUND
B. Hechler* (FR), A. Eckly, S. Magnenat, M. Freund, J. P. Cazenave, F. Lanza, C. Gachet
OC-TH-034
8:45 AM - 9:00 AM
FURTHER PHARMACOLOGICAL AND HISTOLOGICAL CHARACTERIZATION OF A MODEL OF LASER-INDUCED LOCALIZED THROMBOSIS IN MESENTERIC ARTERIOLES WITH STANDARDIZED MODERATE AND SEVERE INJURIES
B. Hechler* (FR), A. Eckly, C. Nonne, S. Magnenat, C. Ravanat, M. Freund, C. Denis, J. P. Cazenave, F. Lanza, C. Gachet
8:45 AM - 9:00 AM
FURTHER PHARMACOLOGICAL AND HISTOLOGICAL CHARACTERIZATION OF A MODEL OF LASER-INDUCED LOCALIZED THROMBOSIS IN MESENTERIC ARTERIOLES WITH STANDARDIZED MODERATE AND SEVERE INJURIES
B. Hechler* (FR), A. Eckly, C. Nonne, S. Magnenat, C. Ravanat, M. Freund, C. Denis, J. P. Cazenave, F. Lanza, C. Gachet
OC-TH-035
9:00 AM - 9:15 AM
HISTOLOGICAL CHARACTERIZATION OF MOUSE CAROTID ARTERY ALTERATION FOLLOWING FERRIC CHLORIDE-INDUCED INJURY
A. Eckly* (FR), M. Freund, M. Zerr Fouineau, J. Cazenave, F. Lanza, B. Hechler, C. Gachet
9:00 AM - 9:15 AM
HISTOLOGICAL CHARACTERIZATION OF MOUSE CAROTID ARTERY ALTERATION FOLLOWING FERRIC CHLORIDE-INDUCED INJURY
A. Eckly* (FR), M. Freund, M. Zerr Fouineau, J. Cazenave, F. Lanza, B. Hechler, C. Gachet
OC-TH-036
9:15 AM - 9:30 AM
TLT-1 PROMOTES THROMBOSIS IN MICE L. Rivera* (PR), R. Hernández, O. González, J. Simon, A. Washington
Chairpersons: Jonathan Gibbins (UK) and Michelle Lambert (US)
9:15 AM - 9:30 AM
TLT-1 PROMOTES THROMBOSIS IN MICE L. Rivera* (PR), R. Hernández, O. González, J. Simon, A. Washington
Chairpersons: Jonathan Gibbins (UK) and Michelle Lambert (US)
OC-TH-037
8:00 AM - 8:15 AM
CHARACTERISATION OF NOVEL PLATELET SURFACE THIOL ISOMERASE ENZYMES
L. Holbrook* (UK), K. L. Jones, N. A. Watkins, C. I. Jones, W. H. Ouwehand, J. M. Gibbins
8:00 AM - 8:15 AM
CHARACTERISATION OF NOVEL PLATELET SURFACE THIOL ISOMERASE ENZYMES
L. Holbrook* (UK), K. L. Jones, N. A. Watkins, C. I. Jones, W. H. Ouwehand, J. M. Gibbins
OC-TH-038
8:15 AM - 8:30 AM
CIB1 IS A KEY REGULATOR OF PLATELET INTEGRIN IIB3-DEPENDENT RETRACTILE SIGNALING
M. U. Naik* (US), U. P. Naik
8:15 AM - 8:30 AM
CIB1 IS A KEY REGULATOR OF PLATELET INTEGRIN IIB3-DEPENDENT RETRACTILE SIGNALING
M. U. Naik* (US), U. P. Naik
OC-TH-039
8:30 AM - 8:45 AM
A GAIN-OF-FUNCTION MUTATION IN THE PHOSPHOLIPASE C GAMMA 2 GENE ENHANCES INTEGRIN OUTSIDE-IN SIGNALING AND LEADS TO A PROTHROMBOTIC PHENOTYPE IN MICE
M. Elvers* (DE), R. Pozgaj, D. Varga-Szabo, F. May, P. Yu, B. Nieswandt
8:30 AM - 8:45 AM
A GAIN-OF-FUNCTION MUTATION IN THE PHOSPHOLIPASE C GAMMA 2 GENE ENHANCES INTEGRIN OUTSIDE-IN SIGNALING AND LEADS TO A PROTHROMBOTIC PHENOTYPE IN MICE
M. Elvers* (DE), R. Pozgaj, D. Varga-Szabo, F. May, P. Yu, B. Nieswandt
OC-TH-040
8:45 AM - 9:00 AM
C-CBL NEGATIVELY REGULATES PLATELET GPVI SIGNALING VIA AN INTERACTION WITH THE HISTIDINE PHOSPATASE TULA-2 AND SYK
D. H. Thomas* (US), C. A. Dangelmaier, J. Jin, A. Y. Tsygankov, S. P. Kunapuli, J. L. Daniel
8:45 AM - 9:00 AM
C-CBL NEGATIVELY REGULATES PLATELET GPVI SIGNALING VIA AN INTERACTION WITH THE HISTIDINE PHOSPATASE TULA-2 AND SYK
D. H. Thomas* (US), C. A. Dangelmaier, J. Jin, A. Y. Tsygankov, S. P. Kunapuli, J. L. Daniel
OC-TH-041
9:00 AM - 9:15 AM
IDENTIFICATION OF A NOVEL PLATELET THROMBOXANE A2 RECEPTOR p.D304N VARIANT WITH REDUCED LIGAND BINDING
A. D. Mumford* (UK), B. B. Dawood, M. E. Daly, J. C. Spalton, S. J. Mundell, S. P. Watson, M. D. Williams
9:00 AM - 9:15 AM
IDENTIFICATION OF A NOVEL PLATELET THROMBOXANE A2 RECEPTOR p.D304N VARIANT WITH REDUCED LIGAND BINDING
A. D. Mumford* (UK), B. B. Dawood, M. E. Daly, J. C. Spalton, S. J. Mundell, S. P. Watson, M. D. Williams
OC-TH-042
9:15 AM - 9:30 AM
SUBSTITUTIONS OF THE UNIQUE BETA3-ARG261 HAVE DIFFERENT EFFECTS ON INTEGRINS ALPHAIIB-BETA3 AND ALPHAV-BETA3
H. Hauschner* (IL), N. Rosenberg, M. Landau, U. Seligsohn
Chairpersons: Anthony Dorling (UK) and Christoph Reinhardt (SE)
9:15 AM - 9:30 AM
SUBSTITUTIONS OF THE UNIQUE BETA3-ARG261 HAVE DIFFERENT EFFECTS ON INTEGRINS ALPHAIIB-BETA3 AND ALPHAV-BETA3
H. Hauschner* (IL), N. Rosenberg, M. Landau, U. Seligsohn
Chairpersons: Anthony Dorling (UK) and Christoph Reinhardt (SE)
OC-TH-043
8:00 AM - 8:15 AM
COMPLETE INHIBITION OF TRANSPLANT ARTERIOSCLEROSIS BY INHIBITING TISSUE FACTOR ON VASCULAR PROGENITOR CELLS
D. Chen* (UK), S. Shrivastava, D. J. Coe, J. Chai, D. M. Scott, J. H. McVey, A. Dorling
8:00 AM - 8:15 AM
COMPLETE INHIBITION OF TRANSPLANT ARTERIOSCLEROSIS BY INHIBITING TISSUE FACTOR ON VASCULAR PROGENITOR CELLS
D. Chen* (UK), S. Shrivastava, D. J. Coe, J. Chai, D. M. Scott, J. H. McVey, A. Dorling
OC-TH-044
8:15 AM - 8:30 AM
EFFECT OF ACUTE INFLAMMATION INDUCED BY PROLONGED EXERCISE ON CIRCULATING STEM/PROGENITOR CELLS THAT MEDIATE TISSUE REPAIR
I. Papassotiriou, A. Spiropoulos, M. Tsironi, K. Skenderi* (GR), A. Margeli, P. Baltopoulos, E. Goussetis
8:15 AM - 8:30 AM
EFFECT OF ACUTE INFLAMMATION INDUCED BY PROLONGED EXERCISE ON CIRCULATING STEM/PROGENITOR CELLS THAT MEDIATE TISSUE REPAIR
I. Papassotiriou, A. Spiropoulos, M. Tsironi, K. Skenderi* (GR), A. Margeli, P. Baltopoulos, E. Goussetis
OC-TH-045
8:30 AM - 8:45 AM
REGULATION OF MOUSE EMBRYONIC STEM CELL COMMITMENT INTO THE ENDOTHELIAL LINEAGE BY P38 MITOGEN-ACTIVATED PROTEIN KINASE
E. Barruet, F. Peiretti, O. Hadadeh, I. Juhan-Vague, M. Alessi, B. Binetruy* (FR)
8:30 AM - 8:45 AM
REGULATION OF MOUSE EMBRYONIC STEM CELL COMMITMENT INTO THE ENDOTHELIAL LINEAGE BY P38 MITOGEN-ACTIVATED PROTEIN KINASE
E. Barruet, F. Peiretti, O. Hadadeh, I. Juhan-Vague, M. Alessi, B. Binetruy* (FR)
OC-TH-046
8:45 AM - 9:00 AM
ALPHA-6 INTEGRIN SUBUNIT PLAYS A MAJOR ROLE IN PROANGIOGENIC PROPERTIES OF ENDOTHELIAL PROGENITOR CELLS
C. Bouvard* (FR), B. Gafsou, B. Dizier, I. Galy-Fauroux, A. Lokajczyk, C. Boisson-Vidal, A. M. Fischer, D. Helley
8:45 AM - 9:00 AM
ALPHA-6 INTEGRIN SUBUNIT PLAYS A MAJOR ROLE IN PROANGIOGENIC PROPERTIES OF ENDOTHELIAL PROGENITOR CELLS
C. Bouvard* (FR), B. Gafsou, B. Dizier, I. Galy-Fauroux, A. Lokajczyk, C. Boisson-Vidal, A. M. Fischer, D. Helley
OC-TH-047
9:00 AM - 9:15 AM
BONE MARROW-DERIVED PROGENITOR CELLS IN ISCHEMIC STROKE PATIENTS: RELATIONSHIP BETWEEN INFARCT SIZE, NEUROLOGICAL IMPAIRMENT AND DISCHARGE OUTCOME
F. Cesari* (IT), A. Gori, R. Marcucci, F. Sofi, V. Palumbo, G. Pracucci, P. Nencini, D. Inzitari, G. Gensini, R. Abbate
9:00 AM - 9:15 AM
BONE MARROW-DERIVED PROGENITOR CELLS IN ISCHEMIC STROKE PATIENTS: RELATIONSHIP BETWEEN INFARCT SIZE, NEUROLOGICAL IMPAIRMENT AND DISCHARGE OUTCOME
F. Cesari* (IT), A. Gori, R. Marcucci, F. Sofi, V. Palumbo, G. Pracucci, P. Nencini, D. Inzitari, G. Gensini, R. Abbate
OC-TH-048
9:15 AM - 9:30 AM
EX VIVO PRETREATMENT OF ENDOTHELIAL PROGENITOR CELLS WITH FUCOIDAN ENHANCES THEIR FUNCTIONAL ACTIVITY FOR CELL THERAPY
C. Boisson-Vidal* (FR), F. Zemani, G. Sarlon, J. P. Duong, B. Dizier, A. Lokajczyk, I. Galy-Fauroux, P. Bruneval, S. Colliec-Jouault, A. M. Fischer, J. Emmerich
Chairperson: Jenny Klintman (SE)
OC-TH-049
8:00 AM - 8:15 AM
NOVEL TOLERANCE PROTOCOL FOR FACTOR VIII
B. Moghimi* (US), B. Sack, S. Nayak, C. Mah, R. Herzog
OC-TH-050
8:15 AM - 8:30 AM
NON-INHIBITORY ANTIBODIES IN THE MIBS COHORT
J. Klintman* (SE), A. Hillarp, E. Berntorp, J. Astermark
OC-TH-051
8:30 AM - 8:45 AM
INTRATHYMIC ADMINISTRATION OF FACTOR VIII RESULTS IN IMMUNE TOLERANCE BY INDUCTION OF FACTOR VIII-SPECIFIC REGULATORY T CELLS IN MURINE HEMOPHILIA A
S. Madoiwa* (JP), T. Yamauchi, E. Kobayashi, Y. Kashiwakura, A. Ishiwata, T. Ohmori, J. Mimuro, Y. Sakata
9:15 AM - 9:30 AM
EX VIVO PRETREATMENT OF ENDOTHELIAL PROGENITOR CELLS WITH FUCOIDAN ENHANCES THEIR FUNCTIONAL ACTIVITY FOR CELL THERAPY
C. Boisson-Vidal* (FR), F. Zemani, G. Sarlon, J. P. Duong, B. Dizier, A. Lokajczyk, I. Galy-Fauroux, P. Bruneval, S. Colliec-Jouault, A. M. Fischer, J. Emmerich
Chairperson: Jenny Klintman (SE) OC-TH-049
8:00 AM - 8:15 AM
NOVEL TOLERANCE PROTOCOL FOR FACTOR VIII
B. Moghimi* (US), B. Sack, S. Nayak, C. Mah, R. Herzog
OC-TH-050
8:15 AM - 8:30 AM
NON-INHIBITORY ANTIBODIES IN THE MIBS COHORT
J. Klintman* (SE), A. Hillarp, E. Berntorp, J. Astermark
OC-TH-051
8:30 AM - 8:45 AM
INTRATHYMIC ADMINISTRATION OF FACTOR VIII RESULTS IN IMMUNE TOLERANCE BY INDUCTION OF FACTOR VIII-SPECIFIC REGULATORY T CELLS IN MURINE HEMOPHILIA A
S. Madoiwa* (JP), T. Yamauchi, E. Kobayashi, Y. Kashiwakura, A. Ishiwata, T. Ohmori, J. Mimuro, Y. Sakata
OC-TH-052
8:45 AM - 9:00 AM
MAPPING THE FVIII BINDING SITE OF THE MONOCLONAL ANTIFACTOR VIII ANTIBODY ESH-8 BY MASS SPECTROMETRY
M. van Geffen* (NL), A. Loof, B. Verbruggen, W. van Heerde
8:45 AM - 9:00 AM
MAPPING THE FVIII BINDING SITE OF THE MONOCLONAL ANTIFACTOR VIII ANTIBODY ESH-8 BY MASS SPECTROMETRY
M. van Geffen* (NL), A. Loof, B. Verbruggen, W. van Heerde
OC-TH-053
9:00 AM - 9:15 AM
DISTINCT T CELL AND B CELL IMMUNE RESPONSES IN BALB/C AND C57BL/6 MICE INFLUENCE THE ANTI-FVIII ANTIBODY TITRE IN HEMOPHILIA A MICE
M. Qadura, B. Waters* (CA), E. Burnett, R. Chegeni, M. Othman, D. Lillicrap
9:00 AM - 9:15 AM
DISTINCT T CELL AND B CELL IMMUNE RESPONSES IN BALB/C AND C57BL/6 MICE INFLUENCE THE ANTI-FVIII ANTIBODY TITRE IN HEMOPHILIA A MICE
M. Qadura, B. Waters* (CA), E. Burnett, R. Chegeni, M. Othman, D. Lillicrap
OC-TH-054
9:15 AM - 9:30 AM
THE RESIDENCE OF FVIII-SPECIFIC MEMORY B CELLS IN HEMOPHILIC MICE AFTER INTRAVENOUS APPLICATION OF FVIII
G. Pordes* (AT), A. Trbic, C. Hausl, E. M. Muchitsch, R. U. Ahmad,
H. J. Ehrlich, H. P. Schwarz, B. M. Reipert
Antithrombotics - Systemic EffectsRoom 204 AB
Chairpersons: Jeffery Weitz (CA) and Irene Martinez-Martinez (ES)
OC-TH-055
8:00 AM - 8:15 AM
ASPIRIN AND CARDIOVASCULAR DISEASE: A CYCLOOXYGENASEINDEPENDENT MODE OF ACTION
R. A. Ajjan* (UK), K. F. Standeven, K. Naseem, M. Khanbhai, F. Phoenix, K. Gersh, J. W. Weisel, R. A. S. Ariens, M. T. Kearney, P. J. Grant
8:00 AM - 8:15 AM
ASPIRIN AND CARDIOVASCULAR DISEASE: A CYCLOOXYGENASEINDEPENDENT MODE OF ACTION
R. A. Ajjan* (UK), K. F. Standeven, K. Naseem, M. Khanbhai, F. Phoenix, K. Gersh, J. W. Weisel, R. A. S. Ariens, M. T. Kearney, P. J. Grant
OC-TH-056
8:15 AM - 8:30 AM
THROMBOSTATIN COMPOUNDS-INHBITION OF PROSTATE CANCER IN VITRO AND IN VIVO
M. T. Nieman* (US), Y. Zhou, G. Larusch, G. Adams, A. H. Schmaier
8:15 AM - 8:30 AM
THROMBOSTATIN COMPOUNDS-INHBITION OF PROSTATE CANCER IN VITRO AND IN VIVO
M. T. Nieman* (US), Y. Zhou, G. Larusch, G. Adams, A. H. Schmaier
OC-TH-057
8:30 AM - 8:45 AM
THROMBOGRAM ANALYSIS OF THE LONG-ACTING ANTICOAGULANT EFFECT OF TB-402, A HUMAN ANTI-FVIII ANTIBODY, AND OF ITS INTERACTIONS WITH RHFVIII, LMWH AND WARFARIN IN HEALTHY VOLUNTEERS
P. Verhamme* (BE), S. Pakola, S. Glazer, J. Stassen, G. Cahillane, T. J. Jensen, J. Saint-Remy, E. Sonesson, P. Giessen, M. Hoylaerts, M. Jacquemin
8:30 AM - 8:45 AM
THROMBOGRAM ANALYSIS OF THE LONG-ACTING ANTICOAGULANT EFFECT OF TB-402, A HUMAN ANTI-FVIII ANTIBODY, AND OF ITS INTERACTIONS WITH RHFVIII, LMWH AND WARFARIN IN HEALTHY VOLUNTEERS
P. Verhamme* (BE), S. Pakola, S. Glazer, J. Stassen, G. Cahillane, T. J. Jensen, J. Saint-Remy, E. Sonesson, P. Giessen, M. Hoylaerts, M. Jacquemin
OC-TH-058
8:45 AM - 9:00 AM
RIVAROXABAN SUPPRESSES PLATELET-RICH THROMBUS FORMATION IN A RAT ARTERIOLAR, LASER-INDUCED INJURY MODEL
C. Gerdes* (DE), M. Schumacher
8:45 AM - 9:00 AM
RIVAROXABAN SUPPRESSES PLATELET-RICH THROMBUS FORMATION IN A RAT ARTERIOLAR, LASER-INDUCED INJURY MODEL
C. Gerdes* (DE), M. Schumacher
OC-TH-059
9:00 AM - 9:15 AM
MAST CELLS INCREASE VASCULAR PERMEABILITY BY HEPARININITIATED BRADYKININ FORMATION IN VIVO
C. Oschatz* (DE), B. Lecher, T. Tradler, M. Paschke, R. Sedlmeier, S. Cichon, S. Hammerschmidt, W. Mueller-Esterl, T. Renné
9:00 AM - 9:15 AM
MAST CELLS INCREASE VASCULAR PERMEABILITY BY HEPARININITIATED BRADYKININ FORMATION IN VIVO
C. Oschatz* (DE), B. Lecher, T. Tradler, M. Paschke, R. Sedlmeier, S. Cichon, S. Hammerschmidt, W. Mueller-Esterl, T. Renné
OC-TH-060
9:15 AM - 9:30 AM
IN VITRO AND IN VIVO ANTITHROMBOTIC EFFECTS OF DIANNEXIN, A NOVEL HOMODIMER OF ANNEXIN A5
M. L. Rand* (CA), P. L. Gross, H. Wang, A. C. Allison, F. G. Pluthero, W. H. Kahr
Chairpersons: David Ginsburg (US) and Mettine Bos (US)
9:15 AM - 9:30 AM
IN VITRO AND IN VIVO ANTITHROMBOTIC EFFECTS OF DIANNEXIN, A NOVEL HOMODIMER OF ANNEXIN A5
M. L. Rand* (CA), P. L. Gross, H. Wang, A. C. Allison, F. G. Pluthero, W. H. Kahr
Chairpersons: David Ginsburg (US) and Mettine Bos (US)
OC-TH-061
8:00 AM - 8:15 AM
INHIBITION OF GROUP A STREPTOCOCCUS VIRULENCE BY SMALL COMPOUNDS AS NOVEL ANTIMICROBIAL REAGENTS
H. Sun* (US), Y. Xu, M. Lapadatescu, S. Larsen, D. Ginsburg
8:00 AM - 8:15 AM
INHIBITION OF GROUP A STREPTOCOCCUS VIRULENCE BY SMALL COMPOUNDS AS NOVEL ANTIMICROBIAL REAGENTS
H. Sun* (US), Y. Xu, M. Lapadatescu, S. Larsen, D. Ginsburg
OC-TH-062
8:15 AM - 8:30 AM
PROTEIN C DEPLETION ENHANCES BACTERIAL OUTGROWTH AND INCREASES MORTALITY IN MURINE PNEUMOCOCCAL SEPSIS
M. Schouten* (NL), C. van ‘T Veer, C. T. Esmon, M. M. Levi, T. van der Poll
8:15 AM - 8:30 AM
PROTEIN C DEPLETION ENHANCES BACTERIAL OUTGROWTH AND INCREASES MORTALITY IN MURINE PNEUMOCOCCAL SEPSIS
M. Schouten* (NL), C. van ‘T Veer, C. T. Esmon, M. M. Levi, T. van der Poll
OC-TH-063
8:30 AM - 8:45 AM
PROLONGED SURVIVAL FOLLOWING MICROBIAL INFECTION IN MICE EXPRESSING THE THROMBIN ANTICOAGULANT MUTANT W215/E217A
M. J. Flick* (US), A. K. Chauhan, E. S. Mullins, J. S. Palumbo, S. Thornton, X. Zheng, N. L. Esmon, C. T. Esmon, D. D. Wagner, J. L. Degen
8:30 AM - 8:45 AM
PROLONGED SURVIVAL FOLLOWING MICROBIAL INFECTION IN MICE EXPRESSING THE THROMBIN ANTICOAGULANT MUTANT W215/E217A
M. J. Flick* (US), A. K. Chauhan, E. S. Mullins, J. S. Palumbo, S. Thornton, X. Zheng, N. L. Esmon, C. T. Esmon, D. D. Wagner, J. L. Degen
OC-TH-064
8:45 AM - 9:00 AM
THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IS DEGRADED BY PLASMINOGEN ACTIVATOR PLA OF YERSINIA PESTIS
M. Valls Serón* (NL), J. Haiko, P. F. Marx, T. K. Korhonen, P. G. de Groot, J. C. M. Meijers
8:45 AM - 9:00 AM
THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR IS DEGRADED BY PLASMINOGEN ACTIVATOR PLA OF YERSINIA PESTIS
M. Valls Serón* (NL), J. Haiko, P. F. Marx, T. K. Korhonen, P. G. de Groot, J. C. M. Meijers
OC-TH-065
9:00 AM - 9:15 AM
INTERACTIONS OF PLASMIN WITH TISSUE FACTOR PATHWAY INHIBITOR (TFPI) IN A MOUSE MODEL OF ENDOTOXEMIA
F. Lupu* (US), O. Herlea, N. I. Popescu, H. Tang, C. Lupu, C. T. Esmon, H. R. Lijnen
9:00 AM - 9:15 AM
INTERACTIONS OF PLASMIN WITH TISSUE FACTOR PATHWAY INHIBITOR (TFPI) IN A MOUSE MODEL OF ENDOTOXEMIA
F. Lupu* (US), O. Herlea, N. I. Popescu, H. Tang, C. Lupu, C. T. Esmon, H. R. Lijnen
OC-TH-066
9:15 AM - 9:30 AM
PROTEIN C DEPLETION ENHANCES INFLAMMATION AND DELAYS MORTALITY IN MURINE LETHAL INFLUENZA A INFECTION
M. Schouten* (NL), K. van der Sluijs, C. van ‘T Veer, C. T. Esmon, M. M. Levi, T. van der Poll
Chairpersons: Carl-Erik Dempfle (DE) and Daniel Frith (UK)
OC-TH-067
8:00 AM - 8:15 AM
ACUTE TRAUMATIC COAGULOPATHY IS DEPENDENT ON BOTH INJURY SEVERITY AND SHOCK: CLINICAL AND EXPERIMENTAL VALIDATION
D. Frith* (UK), S. Stanworth, C. Gaarder, M. Maegele, C. Goslings, P. I. Johansson, S. Allard, M. J. Cohen, R. M. Pearse, C. Thiemermann, K. Brohi
OC-TH-068
8:15 AM - 8:30 AM
FACTOR V LEIDEN MUTATION ENHANCES FIBRIN FORMATION AND DISSOLUTION IN VIVO IN A HUMAN ENDOTOXEMIA MODEL
C. H. Dempfle* (DE), N. Suvajac, E. Elmas, B. Jilma, H. Weiler, M. Borggrefe
9:15 AM - 9:30 AM
PROTEIN C DEPLETION ENHANCES INFLAMMATION AND DELAYS MORTALITY IN MURINE LETHAL INFLUENZA A INFECTION
M. Schouten* (NL), K. van der Sluijs, C. van ‘T Veer, C. T. Esmon, M. M. Levi, T. van der Poll
Chairpersons: Carl-Erik Dempfle (DE) and Daniel Frith (UK)
OC-TH-067
8:00 AM - 8:15 AM
ACUTE TRAUMATIC COAGULOPATHY IS DEPENDENT ON BOTH INJURY SEVERITY AND SHOCK: CLINICAL AND EXPERIMENTAL VALIDATION
D. Frith* (UK), S. Stanworth, C. Gaarder, M. Maegele, C. Goslings, P. I. Johansson, S. Allard, M. J. Cohen, R. M. Pearse, C. Thiemermann, K. Brohi
OC-TH-068
8:15 AM - 8:30 AM
FACTOR V LEIDEN MUTATION ENHANCES FIBRIN FORMATION AND DISSOLUTION IN VIVO IN A HUMAN ENDOTOXEMIA MODEL
C. H. Dempfle* (DE), N. Suvajac, E. Elmas, B. Jilma, H. Weiler, M. Borggrefe
OC-TH-069
8:30 AM - 8:45 AM
EFFICACY AND SAFETY OF RECOMBINANT ACTIVATED FACTOR VII IN THE MANAGEMENT OF HEMORRHAGIC SHOCK DUE TO TRAUMA
C. J. Hauser, K. D. Boffard, R. P. Dutton* (US), G. R. Bernard, M. A. Croce, J. B. Holcomb, A. K. Leppaniemi, M. J. A. Parr, J. L. Vincent, B. J. Tortella, J. Dimsits, B. Bouillon, for the CONTROL Study Group
8:30 AM - 8:45 AM
EFFICACY AND SAFETY OF RECOMBINANT ACTIVATED FACTOR VII IN THE MANAGEMENT OF HEMORRHAGIC SHOCK DUE TO TRAUMA
C. J. Hauser, K. D. Boffard, R. P. Dutton* (US), G. R. Bernard, M. A. Croce, J. B. Holcomb, A. K. Leppaniemi, M. J. A. Parr, J. L. Vincent, B. J. Tortella, J. Dimsits, B. Bouillon, for the CONTROL Study Group
OC-TH-070
8:45 AM - 9:00 AM
EBOLA VIRUS INFECTION MODULATES THE BALANCE BETWEEN TISSUE FACTOR AND THROMBOMODULIN ON ENDOTHELIAL CELLS: RELEVANCE FOR DYSFUNCTIONAL HAEMOSTASIS IN VIRAL INFECTIONS
A. Shibamiya, M. Schuemann, T. Schmidt-Woell, K. T. Preissner, E. Muehlberger, S. M. Kanse* (DE)
8:45 AM - 9:00 AM
EBOLA VIRUS INFECTION MODULATES THE BALANCE BETWEEN TISSUE FACTOR AND THROMBOMODULIN ON ENDOTHELIAL CELLS: RELEVANCE FOR DYSFUNCTIONAL HAEMOSTASIS IN VIRAL INFECTIONS
A. Shibamiya, M. Schuemann, T. Schmidt-Woell, K. T. Preissner, E. Muehlberger, S. M. Kanse* (DE)
OC-TH-071
9:00 AM - 9:15 AM
TEMPORAL ASSOCIATION OF ALPHA-1-PROTEASE INHIBITOR INACTIVATION WITH INCREASED ELASTASE DURING EXPERIMENTAL SEPSIS
J. A. Samis* (CA), K. A. Stewart, M. E. Nesheim, F. B. Taylor Jr
9:00 AM - 9:15 AM
TEMPORAL ASSOCIATION OF ALPHA-1-PROTEASE INHIBITOR INACTIVATION WITH INCREASED ELASTASE DURING EXPERIMENTAL SEPSIS
J. A. Samis* (CA), K. A. Stewart, M. E. Nesheim, F. B. Taylor Jr
OC-TH-072
9:15 AM - 9:30 AM
TEMPORAL ASSOCIATION OF COAGULATION FACTOR INACTIVATION WITH INCREASED ELASTASE DURING EXPERIMENTAL SEPSIS
J. A. Samis* (CA), K. A. Stewart, M. E. Nesheim, F. B. Taylor Jr
Chairpersons: Clive Kearon (CA) and Michael Streiff (US)
9:15 AM - 9:30 AM
TEMPORAL ASSOCIATION OF COAGULATION FACTOR INACTIVATION WITH INCREASED ELASTASE DURING EXPERIMENTAL SEPSIS
J. A. Samis* (CA), K. A. Stewart, M. E. Nesheim, F. B. Taylor Jr
Chairpersons: Clive Kearon (CA) and Michael Streiff (US)
OC-TH-073
4:00 PM - 4:15 PM
CARDIAC BIOMARKERS FOR RISK STRATIFICATION IN NON MASSIVE PULMONARY EMBOLISM: A MULTICENTER PROSPECTIVE STUDY
N. Vuilleumier* (CH), G. Le Gal, F. Verschuren, A. Perrier, H. Bounameaux, N. Turck, J. Sanchez, N. Mensi, T. Perneger, D. Hochstrasser, M. Righini
4:00 PM - 4:15 PM
CARDIAC BIOMARKERS FOR RISK STRATIFICATION IN NON MASSIVE PULMONARY EMBOLISM: A MULTICENTER PROSPECTIVE STUDY
N. Vuilleumier* (CH), G. Le Gal, F. Verschuren, A. Perrier, H. Bounameaux, N. Turck, J. Sanchez, N. Mensi, T. Perneger, D. Hochstrasser, M. Righini
OC-TH-074
4:15 PM - 4:30 PM
EXTENT OF CLINICALLY IMPORTANT DIFFERENCES BETWEEN TWO MEASURES OF THE INTERNATIONAL NORMALIZED RATIO (INR)
K. M. Shermock, B. L. Pinto, P. S. Kraus, M. B. Streiff* (US)
4:15 PM - 4:30 PM
EXTENT OF CLINICALLY IMPORTANT DIFFERENCES BETWEEN TWO MEASURES OF THE INTERNATIONAL NORMALIZED RATIO (INR)
K. M. Shermock, B. L. Pinto, P. S. Kraus, M. B. Streiff* (US)
OC-TH-075
4:30 PM - 4:45 PM
STANDARDIZED LOW MOLECULAR WEIGHT HEPARIN BRIDGING REGIMEN IN OUTPATIENTS ON ORAL ANTICOAGULANTS UNDERGOING INVASIVE PROCEDURE OR SURGERY: AN INCEPTION COHORT MANAGEMENT STUDY
V. Pengo, U. Cucchini, G. Denas* (IT), N. Erba, G. Guazzaloca, L. La Rosa, V. de Micheli, S. Testa, R. Frontoni, D. Prisco, S. Iliceto
4:30 PM - 4:45 PM
STANDARDIZED LOW MOLECULAR WEIGHT HEPARIN BRIDGING REGIMEN IN OUTPATIENTS ON ORAL ANTICOAGULANTS UNDERGOING INVASIVE PROCEDURE OR SURGERY: AN INCEPTION COHORT MANAGEMENT STUDY
V. Pengo, U. Cucchini, G. Denas* (IT), N. Erba, G. Guazzaloca, L. La Rosa, V. de Micheli, S. Testa, R. Frontoni, D. Prisco, S. Iliceto
OC-TH-076
4:45 PM - 5:00 PM
ASSESSING THE UPTAKE OF NATIONAL INITIATIVES TO IMPROVE VENOUS THROMBOEMBOLISM PATIENT CARE IN THE UK
R. Arya* (UK), A. McManus, S. Paneesha, N. Scriven, T. Nokes, T. Farren, A. Nieland, P. Rose, S. Bacon, D. O’Shaughnessy
Chairpersons: Aleksandra Antovic (SE) and Roy Silverstein (US)
4:45 PM - 5:00 PM
ASSESSING THE UPTAKE OF NATIONAL INITIATIVES TO IMPROVE VENOUS THROMBOEMBOLISM PATIENT CARE IN THE UK
R. Arya* (UK), A. McManus, S. Paneesha, N. Scriven, T. Nokes, T. Farren, A. Nieland, P. Rose, S. Bacon, D. O’Shaughnessy
Chairpersons: Aleksandra Antovic (SE) and Roy Silverstein (US)
OC-TH-077
4:00 PM - 4:15 PM
VASCULAR SMOOTH MUSCLE-DERIVED TISSUE FACTOR MEDIATES DEVELOPMENT OF ABDOMINAL AORTIC ANEURYSM INDUCED BY ANGIOTENSIN II INFUSION
L. Wang* (US), D. L. Rateri, C. M. Miller, A. Daugherty, M. B. Taubman
4:00 PM - 4:15 PM
VASCULAR SMOOTH MUSCLE-DERIVED TISSUE FACTOR MEDIATES DEVELOPMENT OF ABDOMINAL AORTIC ANEURYSM INDUCED BY ANGIOTENSIN II INFUSION
L. Wang* (US), D. L. Rateri, C. M. Miller, A. Daugherty, M. B. Taubman
OC-TH-078
4:15 PM - 4:30 PM
PLASMA CONCENTRATIONS OF GROWTH ARREST SPECIFIC PROTEIN 6 (GAS6) AND THE SOLUBLE FORM OF ITS TYROSINE KINASE RECEPTOR AXL AS MARKERS OF LARGE ABDOMINAL AORTIC ANEURYSMS C. Ekman* (SE),
D. Flondell, A. Gottsäter, B. Lindblad, B. Dahlbäck
4:15 PM - 4:30 PM
PLASMA CONCENTRATIONS OF GROWTH ARREST SPECIFIC PROTEIN 6 (GAS6) AND THE SOLUBLE FORM OF ITS TYROSINE KINASE RECEPTOR AXL AS MARKERS OF LARGE ABDOMINAL AORTIC ANEURYSMS C. Ekman* (SE),
D. Flondell, A. Gottsäter, B. Lindblad, B. Dahlbäck
OC-TH-079
4:30 PM - 4:45 PM
GLYCEMIC CONTROL IS OF MAJOR IMPORTANCE FOR FIBRIN CLOT STRUCTURE IN TYPE 1 DIABETES A. Antovic* (SE), F. Mobarrez, S. Tehrani, P. Lins, U. Adamson, N. Wallen, G. Jörneskog
4:30 PM - 4:45 PM
GLYCEMIC CONTROL IS OF MAJOR IMPORTANCE FOR FIBRIN CLOT STRUCTURE IN TYPE 1 DIABETES A. Antovic* (SE), F. Mobarrez, S. Tehrani, P. Lins, U. Adamson, N. Wallen, G. Jörneskog
OC-TH-080
4:45 PM - 5:00 PM
ASSOCIATIONS OF THROMBIN GENERATION WITH RISK OF CARDIOVASCULAR DISEASE IN THE GLASGOW MONICA STUDY
M. Smid* (NL), M. Woodward, A. Rumley, R. van Oerle, H. M. H. Spronk, H. ten Cate, G. Lowe
Chairpersons: Andra James (US) and Marc Blondon (CH)
4:45 PM - 5:00 PM
ASSOCIATIONS OF THROMBIN GENERATION WITH RISK OF CARDIOVASCULAR DISEASE IN THE GLASGOW MONICA STUDY
M. Smid* (NL), M. Woodward, A. Rumley, R. van Oerle, H. M. H. Spronk, H. ten Cate, G. Lowe
Chairpersons: Andra James (US) and Marc Blondon (CH)
OC-TH-081
4:00 PM - 4:15 PM
PATERNAL THROMBOPHILIA AS A RISK FACTOR FOR DEEP VEIN THROMBOSIS (DVT) DURING PREGNANCY AND POSTPARTUM: INFLUENCE OF THE PATERNAL A3 HAPLOTYPE OF THE EPCR GENE ON MATERNAL DVT OCCURRENCE
J. Galanaud* (FR), E. Cochery-Nouvellon, S. Alonso, C. Chauleur, E. Mercier, G. Lissalde-Lavigne, P. Fabbro-Péray, P. Marés, J. Daurés, M. Dauzat, I. Quéré, J. Gris
4:00 PM - 4:15 PM
PATERNAL THROMBOPHILIA AS A RISK FACTOR FOR DEEP VEIN THROMBOSIS (DVT) DURING PREGNANCY AND POSTPARTUM: INFLUENCE OF THE PATERNAL A3 HAPLOTYPE OF THE EPCR GENE ON MATERNAL DVT OCCURRENCE
J. Galanaud* (FR), E. Cochery-Nouvellon, S. Alonso, C. Chauleur, E. Mercier, G. Lissalde-Lavigne, P. Fabbro-Péray, P. Marés, J. Daurés, M. Dauzat, I. Quéré, J. Gris
OC-TH-082
4:15 PM - 4:30 PM
INCREASED LEVELS OF SOLUBLE ENDOTHELIAL CELL PROTEIN C RECEPTOR (SEPCR) IN WOMEN WITH PREECLAMPSIA: WITNESSES OF ENDOTHELIUM DAMAGE, OR NEW RISK FACTOR FOR PREECLAMPSIA?
B. Saposnik* (FR), E. Peynaud-Debayle, A. Stepanian, S. Benchenni, M. Simansour, G. Baron, M. Fontenay, A. Le Querrec, L. Mandelbrot, D. de Prost, S. Gandrille, on behalf of the ECLAXIR Study
4:15 PM - 4:30 PM
INCREASED LEVELS OF SOLUBLE ENDOTHELIAL CELL PROTEIN C RECEPTOR (SEPCR) IN WOMEN WITH PREECLAMPSIA: WITNESSES OF ENDOTHELIUM DAMAGE, OR NEW RISK FACTOR FOR PREECLAMPSIA?
B. Saposnik* (FR), E. Peynaud-Debayle, A. Stepanian, S. Benchenni, M. Simansour, G. Baron, M. Fontenay, A. Le Querrec, L. Mandelbrot, D. de Prost, S. Gandrille, on behalf of the ECLAXIR Study
OC-TH-083
4:30 PM - 4:45 PM
HIGH-DOSE ANTITHROMBIN SUPPLEMENTATION IN EARLY PREECLAMPSIA: A DOUBLE-BLIND, PLACEBO CONTROLLED STUDY (ON BEHALF OF THE ATIII-EPAS STUDY GROUP)
L. Valsecchi, A. D’Angelo* (IT)
4:30 PM - 4:45 PM
HIGH-DOSE ANTITHROMBIN SUPPLEMENTATION IN EARLY PREECLAMPSIA: A DOUBLE-BLIND, PLACEBO CONTROLLED STUDY (ON BEHALF OF THE ATIII-EPAS STUDY GROUP)
L. Valsecchi, A. D’Angelo* (IT)
OC-TH-084
4:45 PM - 5:00 PM
MATERNAL TOBACCO SMOKE EXPOSURE IN WOMEN WITH PREECLAMPSIA IS ASSOCIATED WITH HIGHER BIRTHWEIGHT FOR GESTATIONAL AGE
S. R. Kahn* (CA), N. Almeida, G. Koren, M. Dahou, H. McNamara, R. Platt, M. S. Kramer
Chairpersons: Edward Tuddenham (UK) and Jonathan Finn (US)
4:45 PM - 5:00 PM
MATERNAL TOBACCO SMOKE EXPOSURE IN WOMEN WITH PREECLAMPSIA IS ASSOCIATED WITH HIGHER BIRTHWEIGHT FOR GESTATIONAL AGE
S. R. Kahn* (CA), N. Almeida, G. Koren, M. Dahou, H. McNamara, R. Platt, M. S. Kramer
Chairpersons: Edward Tuddenham (UK) and Jonathan Finn (US)
OC-TH-085
4:00 PM - 4:15 PM
INTRAVENOUS INFUSION OF GENETICALLY-MODIFIED ENDOTHELIAL PROGENITOR CELLS FOR THE TREATMENT OF HEMOPHILIA A: INITIAL TRIALS IN THE HEMOPHILIA A DOG MODEL
H. Matsui* (CA), M. Ozelo, A. Labelle, S. Powell, L. Harpell, C. Hegadorn, P. Thompson, C. Hough, D. Lillicrap
4:00 PM - 4:15 PM
INTRAVENOUS INFUSION OF GENETICALLY-MODIFIED ENDOTHELIAL PROGENITOR CELLS FOR THE TREATMENT OF HEMOPHILIA A: INITIAL TRIALS IN THE HEMOPHILIA A DOG MODEL
H. Matsui* (CA), M. Ozelo, A. Labelle, S. Powell, L. Harpell, C. Hegadorn, P. Thompson, C. Hough, D. Lillicrap
OC-TH-086
4:15 PM - 4:30 PM
REDUCED IMMUNOLOGICAL RESPONSE TO FACTOR VIII IN HEMOPHILIA A MICE ASSOCIATED WITH SUBCUTANEOUS IMPLANTATION OF LENTIVIRALLY-ENGINEERED ENDOTHELIAL PROGENITOR CELLS
H. Matsui* (CA), A. Labelle, C. Hegadorn, P. Thompson, E. Burnett, C. Hough, D. Lillicrap
4:15 PM - 4:30 PM
REDUCED IMMUNOLOGICAL RESPONSE TO FACTOR VIII IN HEMOPHILIA A MICE ASSOCIATED WITH SUBCUTANEOUS IMPLANTATION OF LENTIVIRALLY-ENGINEERED ENDOTHELIAL PROGENITOR CELLS
H. Matsui* (CA), A. Labelle, C. Hegadorn, P. Thompson, E. Burnett, C. Hough, D. Lillicrap
OC-TH-087
4:30 PM - 4:45 PM
ADENO-ASSOCIATED VIRUS VECTOR EXPRESSION OF LARGE GENES IS ENHANCED BY PROTEASOME INHIBITORS AS MODELED IN HEMOPHILIA A MICE AND DOGS
P. E. Monahan* (US), J. Sun, C. D. Lothrop Jr, R. J. Samulski
4:30 PM - 4:45 PM
ADENO-ASSOCIATED VIRUS VECTOR EXPRESSION OF LARGE GENES IS ENHANCED BY PROTEASOME INHIBITORS AS MODELED IN HEMOPHILIA A MICE AND DOGS
P. E. Monahan* (US), J. Sun, C. D. Lothrop Jr, R. J. Samulski
OC-TH-088
4:45 PM - 5:00 PM
DEVELOPMENT OF HUMAN ARTIFICIAL CHROMOSOME VECTORS FOR GENE THERAPY OF HEMOPHILIA A
Y. Yakura* (JP), C. Ishihara, A. Hayashi, T. Matsui, S. Matsumoto, H. Kurosaki, M. Oshimura, T. Doi, N. Komatsu, H. Takeya
Chairperson: Lina Badimon (ES)
OC-TH-089
4:00 PM - 4:15 PM
COMPLEMENT C3 IS A SUBSTRATE FOR FACTOR XIII AND IS INCORPORATED INTO FIBRIN CLOTS – A NOVEL LINK BETWEEN INFLAMMATION AND THROMBOSIS
V. Schroeder* (UK), V. Polkinghorne, K. F. Standeven, P. J. Grant, A. M. Carter
OC-TH-090
4:15 PM - 4:30 PM
TISSUE FACTOR LOCALIZES IN THE LEADING EDGE OF MIGRATING HUMAN VASCULAR SMOOTH MUSCLE CELLS AND ITS DOWNREGULATION SIGNIFICANTLY REDUCES MIGRATION
E. Peña, G. Arderiu, L. Badimon* (ES)
4:45 PM - 5:00 PM
DEVELOPMENT OF HUMAN ARTIFICIAL CHROMOSOME VECTORS FOR GENE THERAPY OF HEMOPHILIA A
Y. Yakura* (JP), C. Ishihara, A. Hayashi, T. Matsui, S. Matsumoto, H. Kurosaki, M. Oshimura, T. Doi, N. Komatsu, H. Takeya
Chairperson: Lina Badimon (ES)
OC-TH-089
4:00 PM - 4:15 PM
COMPLEMENT C3 IS A SUBSTRATE FOR FACTOR XIII AND IS INCORPORATED INTO FIBRIN CLOTS – A NOVEL LINK BETWEEN INFLAMMATION AND THROMBOSIS
V. Schroeder* (UK), V. Polkinghorne, K. F. Standeven, P. J. Grant, A. M. Carter
OC-TH-090
4:15 PM - 4:30 PM
TISSUE FACTOR LOCALIZES IN THE LEADING EDGE OF MIGRATING HUMAN VASCULAR SMOOTH MUSCLE CELLS AND ITS DOWNREGULATION SIGNIFICANTLY REDUCES MIGRATION
E. Peña, G. Arderiu, L. Badimon* (ES)
OC-TH-091
4:30 PM - 4:45 PM
CRP-VLDL COMPLEXES IN SEPSIS G. Wang* (UK), S. Abrams, C. Dowsey, J. Thachil, C. Toh
4:30 PM - 4:45 PM
CRP-VLDL COMPLEXES IN SEPSIS G. Wang* (UK), S. Abrams, C. Dowsey, J. Thachil, C. Toh
OC-TH-092
4:45 PM - 5:00 PM
F11R/JAM-A IS REQUIRED FOR PLATELET ADHESION TO INFLAMED ENDOTHELIAL CELLS (EC): ROLE IN THROMBOGENESIS AND ATHEROSCLEROSIS
B. M. Azari* (US), J. D. Marmur, E. Kornecki, Y. H. Ehrlich, M. O. Salifu, A. Babinska
Chairpersons: Johan Heemskerk (NL) and Justin Hamilton (AU)
4:45 PM - 5:00 PM
F11R/JAM-A IS REQUIRED FOR PLATELET ADHESION TO INFLAMED ENDOTHELIAL CELLS (EC): ROLE IN THROMBOGENESIS AND ATHEROSCLEROSIS
B. M. Azari* (US), J. D. Marmur, E. Kornecki, Y. H. Ehrlich, M. O. Salifu, A. Babinska
Chairpersons: Johan Heemskerk (NL) and Justin Hamilton (AU)
OC-TH-093
4:00 PM - 4:15 PM
CLUSTERING OF PECAM-1 INHIBITS MULTIPLE PLATELET SIGNALING PATHWAYS AND RESULTS IN SIGNIFICANT REDUCTION OF THROMBUS FORMATION
C. I. Jones* (UK), S. F. Garner, L. A. Moraes, W. J. Kaiser, A. Rankin, W. H. Ouwehand, A. H. Goodall, J. M. Gibbins
4:00 PM - 4:15 PM
CLUSTERING OF PECAM-1 INHIBITS MULTIPLE PLATELET SIGNALING PATHWAYS AND RESULTS IN SIGNIFICANT REDUCTION OF THROMBUS FORMATION
C. I. Jones* (UK), S. F. Garner, L. A. Moraes, W. J. Kaiser, A. Rankin, W. H. Ouwehand, A. H. Goodall, J. M. Gibbins
OC-TH-094
4:15 PM - 4:30 PM
ROLE OF PKC ISOFORMS ETA AND EPSILON IN ADP-INDUCED PLATELET FUNCTIONAL RESPONSES – PHARMACOLOGICAL AND GENE KNOCKOUT STUDIES
Y. S. Bynagari* (US), B. Nagy, K. Bhavaraju, S. Kim, D. Woulfe, S. Kunapuli
OC-TH-095
4:30 PM - 4:45 PM
THE ROLE OF PGRMC1 IN PLATELET FUNCTION
Y. Jin* (US), W. Hong, D. Woulfe, D. Kenny, P. F. Bray
OC-TH-096
4:45 PM - 5:00 PM
MECHANISM OF THROMBIN BINDING TO PLATELET GLYCOPROTEIN IB
A. Zarpellon* (US), A. Zampolli, R. A. McClintock, J. R. Roberts, Z. M. Ruggeri
Chairpersons: Paquita Nurden (FR) and Judith Cosemans (NL)
4:15 PM - 4:30 PM
ROLE OF PKC ISOFORMS ETA AND EPSILON IN ADP-INDUCED PLATELET FUNCTIONAL RESPONSES – PHARMACOLOGICAL AND GENE KNOCKOUT STUDIES
Y. S. Bynagari* (US), B. Nagy, K. Bhavaraju, S. Kim, D. Woulfe, S. Kunapuli
OC-TH-095
4:30 PM - 4:45 PM
THE ROLE OF PGRMC1 IN PLATELET FUNCTION
Y. Jin* (US), W. Hong, D. Woulfe, D. Kenny, P. F. Bray
OC-TH-096
4:45 PM - 5:00 PM
MECHANISM OF THROMBIN BINDING TO PLATELET GLYCOPROTEIN IB
A. Zarpellon* (US), A. Zampolli, R. A. McClintock, J. R. Roberts, Z. M. Ruggeri
Chairpersons: Paquita Nurden (FR) and Judith Cosemans (NL)
OC-TH-097
4:00 PM - 4:15 PM
THERE IS A HIGH MORTALITY RATE IN MICE WHEN PLATELET INTEGRIN ? IIB?3 IS LOCKED-IN ITS HIGH AFFINITY STATE
D. A. Wilcox* (US), J. Fang, P. North, P. Nurden, A. T. Nurden, N. Valentin
4:00 PM - 4:15 PM
THERE IS A HIGH MORTALITY RATE IN MICE WHEN PLATELET INTEGRIN ? IIB?3 IS LOCKED-IN ITS HIGH AFFINITY STATE
D. A. Wilcox* (US), J. Fang, P. North, P. Nurden, A. T. Nurden, N. Valentin
OC-TH-098
4:15 PM - 4:30 PM
IMPAIRED ACTIVATION OF PLATELETS LACKING PROTEIN KINASE C THETA ISOFORM
B. Nagy* (US), K. Bhavaraju, T. Getz, Y. B. Bynagari, S. Kim, S. P. Kunapuli
4:15 PM - 4:30 PM
IMPAIRED ACTIVATION OF PLATELETS LACKING PROTEIN KINASE C THETA ISOFORM
B. Nagy* (US), K. Bhavaraju, T. Getz, Y. B. Bynagari, S. Kim, S. P. Kunapuli
OC-TH-099
4:30 PM - 4:45 PM
A ROLE OF PLATELET MEMBRANE MICRODOMAINS IN CLEC-2MEDIATED SIGNAL TRANSDUCTION
K. Suzuki-Inoue* (JP), O. Inoue, Y. Ozaki
4:30 PM - 4:45 PM
A ROLE OF PLATELET MEMBRANE MICRODOMAINS IN CLEC-2MEDIATED SIGNAL TRANSDUCTION
K. Suzuki-Inoue* (JP), O. Inoue, Y. Ozaki
OC-TH-100
4:45 PM - 5:00 PM
A NOVEL ROLE OF GAB1-SHP2-PI3K COMPLEX ON PECAM-1 SIGNALLING IN PLATELETS
L. A. Moraes* (UK), C. I. Jones, J. M. Gibbins
Chairpersons: Andreas Greinacher (DE) and Elodie Boissier (FR)
4:45 PM - 5:00 PM
A NOVEL ROLE OF GAB1-SHP2-PI3K COMPLEX ON PECAM-1 SIGNALLING IN PLATELETS
L. A. Moraes* (UK), C. I. Jones, J. M. Gibbins
Chairpersons: Andreas Greinacher (DE) and Elodie Boissier (FR)
OC-TH-101
4:00 PM - 4:15 PM
QUANTITATIVE INTERPRETATION OF OPTICAL DENSITY MEASUREMENTS OF IGG ANTIBODIES AGAINST HEPARIN/PF 4COMPLEX IN COMPARISON WITH RESULTS OF OUR FUNCTIONAL ASSAY – IS THERE A BETTER CUTOFF VALUE?
F. Bergmann* (DE), C. Bruns, C. Platzer, S. Krell, B. Arndt, A. Gröning
4:00 PM - 4:15 PM
QUANTITATIVE INTERPRETATION OF OPTICAL DENSITY MEASUREMENTS OF IGG ANTIBODIES AGAINST HEPARIN/PF 4COMPLEX IN COMPARISON WITH RESULTS OF OUR FUNCTIONAL ASSAY – IS THERE A BETTER CUTOFF VALUE?
F. Bergmann* (DE), C. Bruns, C. Platzer, S. Krell, B. Arndt, A. Gröning
OC-TH-102
4:15 PM - 4:30 PM
FALSE POSITIVE TESTS FOR HEPARIN INDUCED THROMBOCYTOPENIA IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS
R. Pauzner* (IL), A. Greinacher, K. Selleng, K. Althaus, B. Shenkman, U. Seligsohn
4:15 PM - 4:30 PM
FALSE POSITIVE TESTS FOR HEPARIN INDUCED THROMBOCYTOPENIA IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS
R. Pauzner* (IL), A. Greinacher, K. Selleng, K. Althaus, B. Shenkman, U. Seligsohn
OC-TH-103
4:30 PM - 4:45 PM
BIOMARKER PROFILING OF PLASMA SAMPLES FROM SUSPECTED HEPARIN-INDUCED THROMBOCYTOPENIA PATIENTS USING A PROTEIN CHIP ARRAY METHOD
J. Fareed* (US), H. Zhu, J. Walenga, J. Cunanan, D. Hoppensteadt
4:30 PM - 4:45 PM
BIOMARKER PROFILING OF PLASMA SAMPLES FROM SUSPECTED HEPARIN-INDUCED THROMBOCYTOPENIA PATIENTS USING A PROTEIN CHIP ARRAY METHOD
J. Fareed* (US), H. Zhu, J. Walenga, J. Cunanan, D. Hoppensteadt
OC-TH-104
4:45 PM - 5:00 PM
HOW FREQUENTLY DO EMERGENCY DEPARTMENT PHYSICIANS DOCUMENT RISK ASSESSMENT FOR HEPARIN-INDUCED THROMBOCYTOPENIA?
R. L. Levine* (US), R. T. Funk, G. W. Hergenroeder, M. J. Hursting
Chairpersons: Naomi Esmon (US) and Michael Page (US)
4:45 PM - 5:00 PM
HOW FREQUENTLY DO EMERGENCY DEPARTMENT PHYSICIANS DOCUMENT RISK ASSESSMENT FOR HEPARIN-INDUCED THROMBOCYTOPENIA?
R. L. Levine* (US), R. T. Funk, G. W. Hergenroeder, M. J. Hursting
Chairpersons: Naomi Esmon (US) and Michael Page (US)
OC-TH-105
4:00 PM - 4:15 PM
STRUCTURE-FUNCTION RELATIONSHIPS OF VARIEGIN: A NOVEL CLASS OF THROMBIN INHIBITORS
C. Y. Koh* (SG), S. Kumar, K. Swaminathan, P. Uvaraj, P. Jagadeeswaran, R. M. Kini
4:00 PM - 4:15 PM
STRUCTURE-FUNCTION RELATIONSHIPS OF VARIEGIN: A NOVEL CLASS OF THROMBIN INHIBITORS
C. Y. Koh* (SG), S. Kumar, K. Swaminathan, P. Uvaraj, P. Jagadeeswaran, R. M. Kini
OC-TH-106
4:15 PM - 4:30 PM
HD1 INHIBITS THROMBIN GENERATION BY ATTENUATING PROTHROMBIN ACTIVATION AND THROMBIN FEEDBACK
C. A. Kretz* (CA), K. K. Cuddy, A. R. Stafford, J. C. Fredenburgh, J. I. Weitz
OC-TH-107
4:30 PM - 4:45 PM
RECONSTRUCTED RECOMBINANT FACTOR Xa AS AN ANTIDOTE TO REVERSE ANTICOAGULATION BY FACTOR Xa INHIBITORS
G. Lu* (US), P. Luan, S. J. Hollenbach, K. Abe, F. R. Deguzman, G. Siu, A. Hutchaleelaha, M. Inagaki, P. B. Conley, D. R. Phillips, U. Sinha
4:30 PM - 4:45 PM
RECONSTRUCTED RECOMBINANT FACTOR Xa AS AN ANTIDOTE TO REVERSE ANTICOAGULATION BY FACTOR Xa INHIBITORS
G. Lu* (US), P. Luan, S. J. Hollenbach, K. Abe, F. R. Deguzman, G. Siu, A. Hutchaleelaha, M. Inagaki, P. B. Conley, D. R. Phillips, U. Sinha
OC-TH-108
4:45 PM - 5:00 PM
ANTITHROMBOTIC EFFECTS OF A FACTOR VII ANTISENSE OLIGONUCLEOTIDE IN MICE
J. R. Crosby* (US), D. Gao, C. Zhao, A. Siwkowski, H. Zhang, A. R. MacLeod, B. P. Monia
Chairpersons: Dennis Galanakis (US) and Maartje van den Biggelaar (NL)
4:45 PM - 5:00 PM
ANTITHROMBOTIC EFFECTS OF A FACTOR VII ANTISENSE OLIGONUCLEOTIDE IN MICE
J. R. Crosby* (US), D. Gao, C. Zhao, A. Siwkowski, H. Zhang, A. R. MacLeod, B. P. Monia
Chairpersons: Dennis Galanakis (US) and Maartje van den Biggelaar (NL)
OC-TH-109
4:00 PM - 4:15 PM
SYSTEMS BIOLOGY MODEL OF COMBINED PLATELET ACTIVATION AND BLOOD COAGULATION TESTED OVER A MULTIVARIATE EXPERIMENTAL SPACE
M. S. Chatterjee* (US), W. S. Denney, H. Jing, D. Jager, S. L. Diamond
4:00 PM - 4:15 PM
SYSTEMS BIOLOGY MODEL OF COMBINED PLATELET ACTIVATION AND BLOOD COAGULATION TESTED OVER A MULTIVARIATE EXPERIMENTAL SPACE
M. S. Chatterjee* (US), W. S. Denney, H. Jing, D. Jager, S. L. Diamond
OC-TH-110
4:15 PM - 4:30 PM
THE MARBURG I POLYMORPHISM (G534E) OF FACTOR VII ACTIVATING PROTEASE (FSAP) PREVENTS FVII ACTIVATION, BUT CONTRIBUTES TO THROMBOEMBOLIC RISK DUE TO FVIII ACTIVATION
M. Etscheid* (DE), L. Muhl, D. Pons, K. T. Preissner, W. Ruf, W. Jukema, S. M. Kanse
4:15 PM - 4:30 PM
THE MARBURG I POLYMORPHISM (G534E) OF FACTOR VII ACTIVATING PROTEASE (FSAP) PREVENTS FVII ACTIVATION, BUT CONTRIBUTES TO THROMBOEMBOLIC RISK DUE TO FVIII ACTIVATION
M. Etscheid* (DE), L. Muhl, D. Pons, K. T. Preissner, W. Ruf, W. Jukema, S. M. Kanse
OC-TH-111
4:30 PM - 4:45 PM
INACTIVATION OF PAI-1 BY ACTIVATED FACTOR XII PLAYS A ROLE IN THE CONTACT PHASE DEPENDENT ENHANCEMENT OF FIBRINOLYSIS
A. Tanaka* (JP), Y. Suzuki, N. Kanayama, T. Urano
OC-TH-112
4:45 PM - 5:00 PM
EXPRESSION OF HEMOSTATIC PROTEINS IN THE LYMPHATIC VASCULATURE OF HEALTHY AND SEPTIC BABOONS
C. Lupu, G. A. Harris, R. Silasi-Mansat, L. Ivanciu, F. B. Taylor, G. T. Kinasewitz, F. Lupu* (US)
Chairpersons: Michael Nesheim (CA) and Mary Prorok (US)
4:45 PM - 5:00 PM
EXPRESSION OF HEMOSTATIC PROTEINS IN THE LYMPHATIC VASCULATURE OF HEALTHY AND SEPTIC BABOONS
C. Lupu, G. A. Harris, R. Silasi-Mansat, L. Ivanciu, F. B. Taylor, G. T. Kinasewitz, F. Lupu* (US)
Chairpersons: Michael Nesheim (CA) and Mary Prorok (US)
OC-TH-113
4:00 PM - 4:15 PM
IN VIVO AND IN VITRO PROFIBRINOLYTIC EFFECT OF MMP-10 MEDIATED BY TAFI: A NEW ROLE FOR MMPS ON FIBRINOLYSIS?
J. Orbe* (ES), J. A. Rodriguez, C. Orset, J. Barrenetxe, R. Serrano, E. Angles-Cano, D. Vivien, M. Belzunce, J. A. Paramo
4:00 PM - 4:15 PM
IN VIVO AND IN VITRO PROFIBRINOLYTIC EFFECT OF MMP-10 MEDIATED BY TAFI: A NEW ROLE FOR MMPS ON FIBRINOLYSIS?
J. Orbe* (ES), J. A. Rodriguez, C. Orset, J. Barrenetxe, R. Serrano, E. Angles-Cano, D. Vivien, M. Belzunce, J. A. Paramo
OC-TH-114
4:15 PM - 4:30 PM
STIMULATION OF THE INTRINSIC ENZYMATIC ACTIVITY OF TAFI ATTENUATES CLOT LYSIS
K. Buelens* (BE), G. H. Hassanzadeh, S. Muyldermans, A. Gils, P. J. Declerck
4:15 PM - 4:30 PM
STIMULATION OF THE INTRINSIC ENZYMATIC ACTIVITY OF TAFI ATTENUATES CLOT LYSIS
K. Buelens* (BE), G. H. Hassanzadeh, S. Muyldermans, A. Gils, P. J. Declerck
OC-TH-115
4:30 PM - 4:45 PM
ACTIVE PLATELET-DERIVED TAFI ATTENUATES PLATELET-RICH THROMBUS LYSIS IN VITRO
S. L. Schadinger* (CA), M. B. Boffa
4:30 PM - 4:45 PM
ACTIVE PLATELET-DERIVED TAFI ATTENUATES PLATELET-RICH THROMBUS LYSIS IN VITRO
S. L. Schadinger* (CA), M. B. Boffa
OC-TH-116
4:45 PM - 5:00 PM
CARBOXYPEPTIDASE N: AN ANTIFIBRINOLYTIC CARBOXYPEPTIDASE? P. L. Swanson* (CA), T. Binette, P. Scott, C. Peterson, L. Bajzar
Chairpersons: Gunnar Heine (DE) and V. V. Kakkar, (UK)
4:45 PM - 5:00 PM
CARBOXYPEPTIDASE N: AN ANTIFIBRINOLYTIC CARBOXYPEPTIDASE? P. L. Swanson* (CA), T. Binette, P. Scott, C. Peterson, L. Bajzar
Chairpersons: Gunnar Heine (DE) and V. V. Kakkar, (UK)
OC-TH-117
4:00 PM - 4:15 PM
ASSOCIATIONS OF CIRCULATING NATURAL KILLER CELLS WITH CARDIOVASCULAR DISEASE RISK FACTORS: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
N. S. Jenny* (US), M. Doyle, R. Kronmal, S. Huber, B. M. Psaty, R. P. Tracy
4:00 PM - 4:15 PM
ASSOCIATIONS OF CIRCULATING NATURAL KILLER CELLS WITH CARDIOVASCULAR DISEASE RISK FACTORS: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
N. S. Jenny* (US), M. Doyle, R. Kronmal, S. Huber, B. M. Psaty, R. P. Tracy
OC-TH-118
4:15 PM - 4:30 PM
HIGH ANTIBODY LEVELS TO PATHOGENS, HEAT SHOCK PROTEINS AND THE RISK OF CORONARY ARTERY DISEASE IN INDIAN POPULATION
V. S. Rao, L. A. Mundkur* (IN), J. Shanker, H. Sridhara, J. Shibhu, K. Sibi, K. Hemapriya, V. Ravi Kumar, B. Dhanalakshmi, A. Mani, V. V. Kakkar
4:15 PM - 4:30 PM
HIGH ANTIBODY LEVELS TO PATHOGENS, HEAT SHOCK PROTEINS AND THE RISK OF CORONARY ARTERY DISEASE IN INDIAN POPULATION
V. S. Rao, L. A. Mundkur* (IN), J. Shanker, H. Sridhara, J. Shibhu, K. Sibi, K. Hemapriya, V. Ravi Kumar, B. Dhanalakshmi, A. Mani, V. V. Kakkar
OC-TH-119
4:30 PM - 4:45 PM
THE RHEUMATOID FACTOR MAY BE AN INDEPENDENT RISK FACTOR FOR CORONARY ARTERY DISEASE IN METABOLIC SYNDROME MEN
G. Jong* (TW), T. Ma, L. Tien, M. Chang
4:30 PM - 4:45 PM
THE RHEUMATOID FACTOR MAY BE AN INDEPENDENT RISK FACTOR FOR CORONARY ARTERY DISEASE IN METABOLIC SYNDROME MEN
G. Jong* (TW), T. Ma, L. Tien, M. Chang
OC-TH-120
4:45 PM - 5:00 PM
CALU A29809G POLYMORPHISM ROLE IN CORONARY ATHEROTHROMBOTIC PLAQUES AND PROGNOSTIC INVOLVEMENT
V. Pérez Andreu* (ES), R. Gonzalez Conejero, J. Ruiz Nodar, D. Hernandez Romero, F. Marín, A. Tello Montoliu, A. Antón, V. Vicente, V. Roldan
4:45 PM - 5:00 PM
CALU A29809G POLYMORPHISM ROLE IN CORONARY ATHEROTHROMBOTIC PLAQUES AND PROGNOSTIC INVOLVEMENT
V. Pérez Andreu* (ES), R. Gonzalez Conejero, J. Ruiz Nodar, D. Hernandez Romero, F. Marín, A. Tello Montoliu, A. Antón, V. Vicente, V. Roldan