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Oral Communications
* Presenting Author
Chairpersons: Peter MacCallum (UK) and Mirjam Meltzer (NL)
OC-TU-001
8:00 AM - 8:15 AM
HYPOFIBRINOLYSIS AS A RISK FACTOR FOR THROMBOSIS AND LINKAGE ANALYSISOF CLOT LYSIS TIME IN A PROTEIN C DEFICIENT KINDRED
M. E. Meltzer* (NL), S. J. Hasstedt, C. J. M. Doggen, P. G. de Groot, F. R. Rosendaal, T. Lisman, E. G. Bovill
8:00 AM - 8:15 AM
HYPOFIBRINOLYSIS AS A RISK FACTOR FOR THROMBOSIS AND LINKAGE ANALYSISOF CLOT LYSIS TIME IN A PROTEIN C DEFICIENT KINDRED
M. E. Meltzer* (NL), S. J. Hasstedt, C. J. M. Doggen, P. G. de Groot, F. R. Rosendaal, T. Lisman, E. G. Bovill
OC-TU-002
8:15 AM - 8:30 AM
AIR TRAVEL AND RISK OF VENOUS THROMBOEMBOLISM: A COMMUNITY-BASED STUDY
P. K. MacCallum* (UK), S. Mt-Isa, K. Whyte, L. Letley, J. Martin, M. R. Vickers, E. M. Hennessy, D. Ashby
8:15 AM - 8:30 AM
AIR TRAVEL AND RISK OF VENOUS THROMBOEMBOLISM: A COMMUNITY-BASED STUDY
P. K. MacCallum* (UK), S. Mt-Isa, K. Whyte, L. Letley, J. Martin, M. R. Vickers, E. M. Hennessy, D. Ashby
OC-TU-003
8:30 AM - 8:45 AM
EVALUATING THROMBIN GENERATION IN A FAMILY WITH PROTEIN C DEFICIENCY
K. Brummel-Ziedins* (US), P. W. Callas, T. Orfeo, M. Gissel, M. F. Hockin, K. G. Mann, E. G. Bovill
8:30 AM - 8:45 AM
EVALUATING THROMBIN GENERATION IN A FAMILY WITH PROTEIN C DEFICIENCY
K. Brummel-Ziedins* (US), P. W. Callas, T. Orfeo, M. Gissel, M. F. Hockin, K. G. Mann, E. G. Bovill
OC-TU-004
8:45 AM - 9:00 AM
PROSPECTIVE STUDY OF BODY MASS INDEX AND THE RISK OF PULMONARY EMBOLISM IN WOMEN
C. Kabrhel* (US), R. Varraso, S. Z. Goldhaber, E. Rimm, C. A. Camargo
8:45 AM - 9:00 AM
PROSPECTIVE STUDY OF BODY MASS INDEX AND THE RISK OF PULMONARY EMBOLISM IN WOMEN
C. Kabrhel* (US), R. Varraso, S. Z. Goldhaber, E. Rimm, C. A. Camargo
OC-TU-005
9:00 AM - 9:15 AM
TALLER MEN HAS INCREASED RISK OF VENOUS THROMBOEMBOLISM – THE TROMSO STUDY
K. H. Borch* (NO), S. Kufaas-Braekkan, E. Mathiesen, I. Njolstad, T. Wilsgaard, J. Stormer, J. Hansen
9:00 AM - 9:15 AM
TALLER MEN HAS INCREASED RISK OF VENOUS THROMBOEMBOLISM – THE TROMSO STUDY
K. H. Borch* (NO), S. Kufaas-Braekkan, E. Mathiesen, I. Njolstad, T. Wilsgaard, J. Stormer, J. Hansen
OC-TU-006
9:15 AM - 9:30 AM
HDL CHOLESTEROL AND FUTURE RISK OF VENOUS THROMBOEMBOLISM – THE TROMSO STUDY
K. H. Borch* (NO), S. Kufaas-Braekkan, E. Mathiesen, I. Njolstad, T. Wilsgaard, J. Stormer, J. Hansen
Chairpersons: Gregoire LeGal (FR) and Nadine Gibson (NL)
9:15 AM - 9:30 AM
HDL CHOLESTEROL AND FUTURE RISK OF VENOUS THROMBOEMBOLISM – THE TROMSO STUDY
K. H. Borch* (NO), S. Kufaas-Braekkan, E. Mathiesen, I. Njolstad, T. Wilsgaard, J. Stormer, J. Hansen
Chairpersons: Gregoire LeGal (FR) and Nadine Gibson (NL)
OC-TU-007
8:00 AM - 8:15 AM
PROSPECTIVE MULTI-CENTER ASSESSMENT OF INTEROBSERVER AGREEMENT FOR RADIOLOGIST INTERPRETATION OF 64-CHANNEL CT ANGIOGRAPHY FOR PULMONARY EMBOLISM
D. M. Courtney* (US), N. T. Klekowski, C. D. Miller, H. A. Smithline, M. M. Hogg, J. A. Kline
8:00 AM - 8:15 AM
PROSPECTIVE MULTI-CENTER ASSESSMENT OF INTEROBSERVER AGREEMENT FOR RADIOLOGIST INTERPRETATION OF 64-CHANNEL CT ANGIOGRAPHY FOR PULMONARY EMBOLISM
D. M. Courtney* (US), N. T. Klekowski, C. D. Miller, H. A. Smithline, M. M. Hogg, J. A. Kline
OC-TU-008
8:15 AM - 8:30 AM
AN ALTERNATIVE DIAGNOSTIC STRATEGY WITH LOWER RADIATIOIN RISK IN YOUNG WOMEN WITH SUSPECTED PULMONARY EMBOLISM
R. A. Douma* (NL), P. W. Kamphuisen, A. J. M. Rijnders, B. Hendrickx, M. ten Wolde, H. R. Büller
8:15 AM - 8:30 AM
AN ALTERNATIVE DIAGNOSTIC STRATEGY WITH LOWER RADIATIOIN RISK IN YOUNG WOMEN WITH SUSPECTED PULMONARY EMBOLISM
R. A. Douma* (NL), P. W. Kamphuisen, A. J. M. Rijnders, B. Hendrickx, M. ten Wolde, H. R. Büller
OC-TU-009
8:30 AM - 8:45 AM
DETECTION OF PULMONARY EMBOLI WITH 99MTC-LABELED ANTIFIBRIN FAB’ FRAGMENTS (THROMBOVIEW): PHASE II STUDY
T. A. Morris* (US), M. Gerometta, R. H. White, R. D. Yusen, J. D. Douketis, S. S. Kaatz, J. S. Ginsberg
8:30 AM - 8:45 AM
DETECTION OF PULMONARY EMBOLI WITH 99MTC-LABELED ANTIFIBRIN FAB’ FRAGMENTS (THROMBOVIEW): PHASE II STUDY
T. A. Morris* (US), M. Gerometta, R. H. White, R. D. Yusen, J. D. Douketis, S. S. Kaatz, J. S. Ginsberg
OC-TU-010
8:45 AM - 9:00 AM
SAFETY AND SENSITIVITY OF TWO ULTRASOUND STRATEGIES IN PATIENTS WITH CLINICALLY SUSPECTED DEEP VENOUS THROMBOSIS; A PROSPECTIVE MANAGEMENT STUDY
N. S. Gibson* (NL), S. M. Schellong, D. Y. El Kheir, J. Beyer, A. S. Gallus, S. McRae, R. E. G. Schutgens, F. Piovella, V. E. A. Gerdes, H. R. Buller
8:45 AM - 9:00 AM
SAFETY AND SENSITIVITY OF TWO ULTRASOUND STRATEGIES IN PATIENTS WITH CLINICALLY SUSPECTED DEEP VENOUS THROMBOSIS; A PROSPECTIVE MANAGEMENT STUDY
N. S. Gibson* (NL), S. M. Schellong, D. Y. El Kheir, J. Beyer, A. S. Gallus, S. McRae, R. E. G. Schutgens, F. Piovella, V. E. A. Gerdes, H. R. Buller
OC-TU-011
9:00 AM - 9:15 AM
VALIDATION OF A DIAGNOSTIC APPROACH TO EXCLUDE RECURRENT VENOUS THROMBOEMBOLISM
G. Le Gal* (FR), M. J. Kovacs, M. Carrier, K. Do, S. R. Kahn, P. S. Wells, D. A. Anderson, I. Chagnon, S. Solymoss, M. Crowther, M. Righini, A. Perrier, R. H. White, L. Vickars, M. Rodger
9:00 AM - 9:15 AM
VALIDATION OF A DIAGNOSTIC APPROACH TO EXCLUDE RECURRENT VENOUS THROMBOEMBOLISM
G. Le Gal* (FR), M. J. Kovacs, M. Carrier, K. Do, S. R. Kahn, P. S. Wells, D. A. Anderson, I. Chagnon, S. Solymoss, M. Crowther, M. Righini, A. Perrier, R. H. White, L. Vickars, M. Rodger
OC-TU-012
9:15 AM - 9:30 AM
COMMON ALTERNATIVE DIAGNOSES AFTER EXCLUSION OF DEEP VENOUS THROMBOSIS IN SYMPTOMATIC PATIENTS IN GENERAL PRACTICE
A. J. ten Cate-Hoek* (NL), H. R. Büller, A. W. Hoes, K. M. G. Moons, R. Oudega, D. B. Toll, E. van der Velde, H. van Weert, M. H. Prins, H. E. J. H. Stoffers
Chairpersons: Alok A. Khorana (US) and Richard White (US)
9:15 AM - 9:30 AM
COMMON ALTERNATIVE DIAGNOSES AFTER EXCLUSION OF DEEP VENOUS THROMBOSIS IN SYMPTOMATIC PATIENTS IN GENERAL PRACTICE
A. J. ten Cate-Hoek* (NL), H. R. Büller, A. W. Hoes, K. M. G. Moons, R. Oudega, D. B. Toll, E. van der Velde, H. van Weert, M. H. Prins, H. E. J. H. Stoffers
Chairpersons: Alok A. Khorana (US) and Richard White (US)
OC-TU-013
8:00 AM - 8:15 AM
ELEVATED C-REACTIVE PROTEIN (CRP) LEVELS ARE ASSOCIATED WITH RISK OF OCCURRENCE OF VENOUS THROMBOEMBOLISM (VTE) IN CANCER PATIENTS – RESULTS FROM THE VIENNA CANCER AND THROMBOSIS STUDY (CATS) R. Kanz* (AT),
T. Vukovich, C. Ay, D. Dunkler, R. Vormittag, J. Haselboeck, C. Zielinski, I. Pabinger
8:00 AM - 8:15 AM
ELEVATED C-REACTIVE PROTEIN (CRP) LEVELS ARE ASSOCIATED WITH RISK OF OCCURRENCE OF VENOUS THROMBOEMBOLISM (VTE) IN CANCER PATIENTS – RESULTS FROM THE VIENNA CANCER AND THROMBOSIS STUDY (CATS) R. Kanz* (AT),
T. Vukovich, C. Ay, D. Dunkler, R. Vormittag, J. Haselboeck, C. Zielinski, I. Pabinger
OC-TU-014
8:15 AM - 8:30 AM
INCIDENCE OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH LYMPHOMA
S. J. Conlon* (US), R. H. White, H. K. Chew, T. Wun
8:15 AM - 8:30 AM
INCIDENCE OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH LYMPHOMA
S. J. Conlon* (US), R. H. White, H. K. Chew, T. Wun
OC-TU-015
8:30 AM - 8:45 AM
PREDICTION OF VENOUS THROMBOEMBOLISM IN CANCER PATIENTS BY MEASURING THROMBIN GENERATION - RESULTS FROM THE VIENNA CANCER AND THROMBOSIS STUDY (CATS)
C. Ay* (AT), R. Simanek, D. Dunkler, J. Thaler, S. Koder, O. Wagner, C. Zielinski, I. Pabinger
8:30 AM - 8:45 AM
PREDICTION OF VENOUS THROMBOEMBOLISM IN CANCER PATIENTS BY MEASURING THROMBIN GENERATION - RESULTS FROM THE VIENNA CANCER AND THROMBOSIS STUDY (CATS)
C. Ay* (AT), R. Simanek, D. Dunkler, J. Thaler, S. Koder, O. Wagner, C. Zielinski, I. Pabinger
OC-TU-016
8:45 AM - 9:00 AM
BIOMARKERS IMPROVE THE RISK SCORING MODEL FOR PREDICTION OF CANCER-ASSOCIATED THROMBOSIS
C. Ay* (AT), A. L. Chiriac, D. Dunkler, R. Vormittag, R. Simanek, P. Quehenberger, C. Zielinski, I. Pabinger
8:45 AM - 9:00 AM
BIOMARKERS IMPROVE THE RISK SCORING MODEL FOR PREDICTION OF CANCER-ASSOCIATED THROMBOSIS
C. Ay* (AT), A. L. Chiriac, D. Dunkler, R. Vormittag, R. Simanek, P. Quehenberger, C. Zielinski, I. Pabinger
OC-TU-017
9:00 AM - 9:15 AM
INCREASED MICROPARTICLE TISSUE FACTOR ACTIVITY IN CANCER PATIENTS WITH VENOUS THROMBOEMBOLISM
D. A. Manly* (US), J. Wang, R. Kasthuri, H. Liebman, N. S. Key, N. Mackman
9:00 AM - 9:15 AM
INCREASED MICROPARTICLE TISSUE FACTOR ACTIVITY IN CANCER PATIENTS WITH VENOUS THROMBOEMBOLISM
D. A. Manly* (US), J. Wang, R. Kasthuri, H. Liebman, N. S. Key, N. Mackman
OC-TU-018
9:15 AM - 9:30 AM
LEUKOCYTOSIS, THROMBOSIS AND MORTALITY IN CANCER
G. C. Connolly* (US), N. M. Kuderer, E. Culakova, C. W. Francis, G. H. Lyman, A. A. Khorana
Chairpersons: David Bergqvist (SE) and Cecilia Becattini (IT)
9:15 AM - 9:30 AM
LEUKOCYTOSIS, THROMBOSIS AND MORTALITY IN CANCER
G. C. Connolly* (US), N. M. Kuderer, E. Culakova, C. W. Francis, G. H. Lyman, A. A. Khorana
Chairpersons: David Bergqvist (SE) and Cecilia Becattini (IT)
OC-TU-019
8:00 AM - 8:15 AM
EVALUATION OF DURATION OF THROMBOEMBOLIC PROPHYLAXIS AFTER MAJOR ORTHOPEDIC SURGERY: THE ETHOS REGISTRY
D. Bergqvist* (SE), J. Arcelus, P. Felicissimo
8:00 AM - 8:15 AM
EVALUATION OF DURATION OF THROMBOEMBOLIC PROPHYLAXIS AFTER MAJOR ORTHOPEDIC SURGERY: THE ETHOS REGISTRY
D. Bergqvist* (SE), J. Arcelus, P. Felicissimo
OC-TU-020
8:15 AM - 8:30 AM
BURDEN OF ILLNESS OF VENOUS THROMBOEMBOLISM AFTER TOTAL HIP AND KNEE REPLACEMENT IN CANADA
R. Selby* (CA), D. Becker, H. McDonald, S. Cartier, M. Crowther, P. Wells
OC-TU-021
8:30 AM - 8:45 AM
VARIATION IN MAJOR BLEEDING DEFINITIONS IN PHASE III ORTHOPEDIC VTE PROPHYLAXIS TRIALS AND THE IMPACT ON MAJOR BLEEDING FREQUENCY R.
D. Hull* (CA), R. D. Yusen, D. Bergvist
OC-TU-022 8:45 AM - 9:00 AM
ULTRASOUND SCREENING OF DEEP VENOUS THROMBOSIS (DVT) AND DURATION OF THROMBOPROPHYLAXIS AFTER TOTAL KNEE ARTHROPLASTY (TKA): THE RANDOMIZED MULTICENTER PROTHEGE STUDY ON 878 PATIENTS
M. T. Barrellier* (FR), B. Lebel, P. Mismetti, J. Parienti, J. Dutheil, C. H. Vielpeau
8:15 AM - 8:30 AM
BURDEN OF ILLNESS OF VENOUS THROMBOEMBOLISM AFTER TOTAL HIP AND KNEE REPLACEMENT IN CANADA
R. Selby* (CA), D. Becker, H. McDonald, S. Cartier, M. Crowther, P. Wells
OC-TU-021
8:30 AM - 8:45 AM
VARIATION IN MAJOR BLEEDING DEFINITIONS IN PHASE III ORTHOPEDIC VTE PROPHYLAXIS TRIALS AND THE IMPACT ON MAJOR BLEEDING FREQUENCY R.
D. Hull* (CA), R. D. Yusen, D. Bergvist
OC-TU-022 8:45 AM - 9:00 AM
ULTRASOUND SCREENING OF DEEP VENOUS THROMBOSIS (DVT) AND DURATION OF THROMBOPROPHYLAXIS AFTER TOTAL KNEE ARTHROPLASTY (TKA): THE RANDOMIZED MULTICENTER PROTHEGE STUDY ON 878 PATIENTS
M. T. Barrellier* (FR), B. Lebel, P. Mismetti, J. Parienti, J. Dutheil, C. H. Vielpeau
OC-TU-023
9:00 AM - 9:15 AM
AN ASSESSMENT OF SURGICAL THROMBOPROPHYLAXIS IN A TERTIARY CARE CENTER
C. Robinson-Cohen* (US), V. Tagalakis, M. Dubois, D. Pilon
9:00 AM - 9:15 AM
AN ASSESSMENT OF SURGICAL THROMBOPROPHYLAXIS IN A TERTIARY CARE CENTER
C. Robinson-Cohen* (US), V. Tagalakis, M. Dubois, D. Pilon
OC-TU-024
9:15 AM - 9:30 AM
ANTITHROMBOTIC PROPHYLAXIS FOR LAPAROSCOPIC CHOLECYSTECTOMY: A META-ANALYSIS
C. Becattini* (IT), F. Rondelli, G. Manina, G. Noya, G. Agnelli
Chairpersons: Alison H. Goodall (UK) and Kan Chen (US)
9:15 AM - 9:30 AM
ANTITHROMBOTIC PROPHYLAXIS FOR LAPAROSCOPIC CHOLECYSTECTOMY: A META-ANALYSIS
C. Becattini* (IT), F. Rondelli, G. Manina, G. Noya, G. Agnelli
Chairpersons: Alison H. Goodall (UK) and Kan Chen (US)
OC-TU-025
8:00 AM - 8:15 AM
PLATELET TRANSCRIPTOME PROFILING IN STABLE ANGINA AND NON-ST ELEVATION ACUTE CORONARY SYNDROME
K. Gertow, G. Marenzi, G. Colombo, M. Brambilla, L. Ruggiero, M. de Metrio, E. Tremoli, M. Camera* (IT)
8:00 AM - 8:15 AM
PLATELET TRANSCRIPTOME PROFILING IN STABLE ANGINA AND NON-ST ELEVATION ACUTE CORONARY SYNDROME
K. Gertow, G. Marenzi, G. Colombo, M. Brambilla, L. Ruggiero, M. de Metrio, E. Tremoli, M. Camera* (IT)
OC-TU-026
8:15 AM - 8:30 AM
PLATELET PROTEINS AS A MEMORY FOR THE BLOOD PRESSURE STATUS IN ANGIOTENSIN-II-INDUCED HYPERTENSION
S. Gebhard* (DE), L. Steil, M. Gesell-Salazar, B. Kuttler, J. Peters, R. Rettig, U. Völker, A. Greinacher
8:15 AM - 8:30 AM
PLATELET PROTEINS AS A MEMORY FOR THE BLOOD PRESSURE STATUS IN ANGIOTENSIN-II-INDUCED HYPERTENSION
S. Gebhard* (DE), L. Steil, M. Gesell-Salazar, B. Kuttler, J. Peters, R. Rettig, U. Völker, A. Greinacher
OC-TU-027
8:30 AM - 8:45 AM
PLATELET ACTIVATION AND INCREASED ADHESION TO POLYMORPHONUCLEAR NEUTROPHILS ACTIVATES OXIDATIVE BURST IN THE NY1DD TRANSGENIC MOUSE MODEL OF SICKLE CELL DISEASE
R. K. Polanowska-Grabowska* (US), K. Wallace, R. Figler, L. Chen, A. R. L. Gear, J. Linden
8:30 AM - 8:45 AM
PLATELET ACTIVATION AND INCREASED ADHESION TO POLYMORPHONUCLEAR NEUTROPHILS ACTIVATES OXIDATIVE BURST IN THE NY1DD TRANSGENIC MOUSE MODEL OF SICKLE CELL DISEASE
R. K. Polanowska-Grabowska* (US), K. Wallace, R. Figler, L. Chen, A. R. L. Gear, J. Linden
OC-TU-028
8:45 AM - 9:00 AM
PLATELET-ASSOCIATED COMPLEMENT FACTOR H IN NORMAL INDIVIDUALS AND PATIENTS WITH ATYPICAL HUS
C. Licht* (CA), F. G. Pluthero, P. F. Zipfel, W. H. A. Kahr
8:45 AM - 9:00 AM
PLATELET-ASSOCIATED COMPLEMENT FACTOR H IN NORMAL INDIVIDUALS AND PATIENTS WITH ATYPICAL HUS
C. Licht* (CA), F. G. Pluthero, P. F. Zipfel, W. H. A. Kahr
OC-TU-029
9:00 AM - 9:15 AM
INCREASE IN MRNA LEVELS OF PLATELET-SPECIFIC GENES WITHIN AN ARTERIAL THROMBUS
J. R. Wright, P. Ellis, C. Landford, N. A. Watkins, W. H. Ouwehand, A. H. Goodall* (UK)
9:00 AM - 9:15 AM
INCREASE IN MRNA LEVELS OF PLATELET-SPECIFIC GENES WITHIN AN ARTERIAL THROMBUS
J. R. Wright, P. Ellis, C. Landford, N. A. Watkins, W. H. Ouwehand, A. H. Goodall* (UK)
OC-TU-030
9:15 AM - 9:30 AM
MLCK1A IS EXPRESSED IN ZEBRAFISH THROMBOCYTES AND AN ESSENTIAL COMPONENT FOR THROMBUS FORMATION
E. Tournoij* (NL), G. J. Weber, J. N. Akkerman, P. G. de Groot, L. I. Zon, F. L. Moll, S. Schulte-Merker
Chairpersons: Katherine High (US) and Randal Westrick (US)
9:15 AM - 9:30 AM
MLCK1A IS EXPRESSED IN ZEBRAFISH THROMBOCYTES AND AN ESSENTIAL COMPONENT FOR THROMBUS FORMATION
E. Tournoij* (NL), G. J. Weber, J. N. Akkerman, P. G. de Groot, L. I. Zon, F. L. Moll, S. Schulte-Merker
Chairpersons: Katherine High (US) and Randal Westrick (US)
OC-TU-031
8:00 AM - 8:15 AM
IDENTIFICATION OF HEMOSTATIC MODIFIER GENES RESCUING FVII DEFICIENT MICE E.
D. Rosen* (US)
8:00 AM - 8:15 AM
IDENTIFICATION OF HEMOSTATIC MODIFIER GENES RESCUING FVII DEFICIENT MICE E.
D. Rosen* (US)
OC-TU-032
8:15 AM - 8:30 AM
INFLUENCE OF THE GENETIC STATUS ON ENDOTHELIAL CELL PROTEIN C RECEPTOR (EPCR) MRNA FORMS FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC), AND ON SOLUBLE EPCR (SEPCR) LEVELS
B. Saposnik, P. Gaussem, A. Lokajczyk, J. L. Reny, M. Aiach, S. Gandrille* (FR)
8:15 AM - 8:30 AM
INFLUENCE OF THE GENETIC STATUS ON ENDOTHELIAL CELL PROTEIN C RECEPTOR (EPCR) MRNA FORMS FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC), AND ON SOLUBLE EPCR (SEPCR) LEVELS
B. Saposnik, P. Gaussem, A. Lokajczyk, J. L. Reny, M. Aiach, S. Gandrille* (FR)
OC-TU-033
8:30 AM - 8:45 AM
TWO SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) IN THE ENDOTHELIAL PROTEIN C RECEPTOR (EPCR) GENE ARE ASSOCIATED WITH LOWER SOLUBLE EPCR (SEPCR), LOW COMPLEMENT C4 AND THROMBOTIC RISK IN PATIENTS WITH LUPUS (SLE)
J. T. Merrill* (US), S. Kamp, K. Thomas, B. J. Woodhams, N. L. Esmon
8:30 AM - 8:45 AM
TWO SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) IN THE ENDOTHELIAL PROTEIN C RECEPTOR (EPCR) GENE ARE ASSOCIATED WITH LOWER SOLUBLE EPCR (SEPCR), LOW COMPLEMENT C4 AND THROMBOTIC RISK IN PATIENTS WITH LUPUS (SLE)
J. T. Merrill* (US), S. Kamp, K. Thomas, B. J. Woodhams, N. L. Esmon
OC-TU-034
8:45 AM - 9:00 AM
GENOME-WIDE ASSOCIATION STUDY REVEALS MULTIPLE NOVEL GENETIC LOCI WITH PLASMA LEVELS OF COAGULATION FACTOR VII, FACTOR VIII, AND VON WILLEBRAND FACTOR: THE COHORTS FOR HEART AND AGING RESEARCH IN GENOME EPIDEMIOLOGY (CHARGE) CONSORTIUM
N. L. Smith* (US), W. Tang, M. de Maat, W. L. McArdle, M. Chen, A. Peters, W. Koenig, E. G. Bovill, S. Basu, J. C. M. Witteman, D. Strachan, C. J. O’Donnell
8:45 AM - 9:00 AM
GENOME-WIDE ASSOCIATION STUDY REVEALS MULTIPLE NOVEL GENETIC LOCI WITH PLASMA LEVELS OF COAGULATION FACTOR VII, FACTOR VIII, AND VON WILLEBRAND FACTOR: THE COHORTS FOR HEART AND AGING RESEARCH IN GENOME EPIDEMIOLOGY (CHARGE) CONSORTIUM
N. L. Smith* (US), W. Tang, M. de Maat, W. L. McArdle, M. Chen, A. Peters, W. Koenig, E. G. Bovill, S. Basu, J. C. M. Witteman, D. Strachan, C. J. O’Donnell
OC-TU-035
9:00 AM - 9:15 AM
ANNEXIN V GENE INVOLVEMENT IN THE OCCURRENCE OF GESTATIONAL VASCULAR DISORDERS
G. L. Tiscia, D. Colaizzo, E. Chinni, D. Pisanelli, N. Scianname’, G. Favuzzi, M. Margaglione, E. Grandone* (IT)
9:00 AM - 9:15 AM
ANNEXIN V GENE INVOLVEMENT IN THE OCCURRENCE OF GESTATIONAL VASCULAR DISORDERS
G. L. Tiscia, D. Colaizzo, E. Chinni, D. Pisanelli, N. Scianname’, G. Favuzzi, M. Margaglione, E. Grandone* (IT)
OC-TU-036
9:15 AM - 9:30 AM
FINE MAPPING OF MOUSE CHROMOSOME 11 THROMBOSIS MODIFIERS USING CONGENIC MOUSE STRAINS
Q. Sa* (US), J. L. Hoover-Plow
Chairpersons: Nathalie Satta-Poschung (CH) and Jacob Rand (US)
9:15 AM - 9:30 AM
FINE MAPPING OF MOUSE CHROMOSOME 11 THROMBOSIS MODIFIERS USING CONGENIC MOUSE STRAINS
Q. Sa* (US), J. L. Hoover-Plow
Chairpersons: Nathalie Satta-Poschung (CH) and Jacob Rand (US)
OC-TU-037
8:00 AM - 8:15 AM
ANTIPHOSPHOLIPID ANTIBODIES STIMULATE HUMAN CELLS VIA TLR2 AND CD14
N. Satta* (CH), S. Dunoyer-Geindre, F. Boehlen, G. Reber, E. K. O. Kruithof, P. de Moerloose
8:00 AM - 8:15 AM
ANTIPHOSPHOLIPID ANTIBODIES STIMULATE HUMAN CELLS VIA TLR2 AND CD14
N. Satta* (CH), S. Dunoyer-Geindre, F. Boehlen, G. Reber, E. K. O. Kruithof, P. de Moerloose
OC-TU-038
8:15 AM - 8:30 AM
INDUCTION OF PATHOGENIC ANTIPHOSPHOLIPID ANTIBODIES IN VIVO ARE DEPENDENT ON EXPRESSION OF MHC-II GENES
S. S. Pierangeli* (US), E. Papalardo, Z. Romay-Penabad, A. Ibarra, P. Christadoss
8:15 AM - 8:30 AM
INDUCTION OF PATHOGENIC ANTIPHOSPHOLIPID ANTIBODIES IN VIVO ARE DEPENDENT ON EXPRESSION OF MHC-II GENES
S. S. Pierangeli* (US), E. Papalardo, Z. Romay-Penabad, A. Ibarra, P. Christadoss
OC-TU-039
8:30 AM - 8:45 AM
ASSOCIATION OF ANTI-B2GPI DOMAIN I IGG AND RESISTANCE TO ANNEXIN A5 WITH OBSTETRICAL ANTIPHOSPHOLIPID SYNDROME: EVIDENCE FOR A SPECIFIC MECHANISM IN A PATIENT SUBSET
B. J. Hunt* (UK), X. Wu, B. de Laat, A. A. Arslan, K. Parmar, S. Stuart-Smith, J. H. Rand
8:30 AM - 8:45 AM
ASSOCIATION OF ANTI-B2GPI DOMAIN I IGG AND RESISTANCE TO ANNEXIN A5 WITH OBSTETRICAL ANTIPHOSPHOLIPID SYNDROME: EVIDENCE FOR A SPECIFIC MECHANISM IN A PATIENT SUBSET
B. J. Hunt* (UK), X. Wu, B. de Laat, A. A. Arslan, K. Parmar, S. Stuart-Smith, J. H. Rand
OC-TU-040
8:45 AM - 9:00 AM
ANTI- BETA2- GLYCOPROTEIN I ANTIBODIES DIRECTED TO DOMAIN I IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME (APS) AND TRIPLE LABORATORY POSITIVITY
A. Banzato* (IT), N. Pozzi, V. Defilippis, E. Bison, M. Tonello, A. Ruffatti, V. Pengo
OC-TU-041
9:00 AM - 9:15 AM
COVALENTLY ASSOCIATED DIMERS AND MULTIMERS OF B2 GLYCOPROTEIN I
T. Matsui* (JP), A. Hayashi, Y. Yakura, S. Matsumoto, H. Takeya
OC-TU-042 9:15 AM - 9:30 AM
MODULATION OF KLF2 AND KLF4 BY ANTIPHOSPHOLIPID ANTIBODIES
K. L. Allen* (US), D. Kawanami, M. K. Jain, K. R. McCrae
Chairpersons: Joel Bennett (US) and Matthew Jones (UK)
OC-TU-043
8:00 AM - 8:15 AM
STRUCTURE OF THE GLYCOPROTEIN IB-BETA ECTODOMAIN
P. A. McEwan, X. Zheng, R. Li, J. Emsley* (UK)
OC-TU-044
8:15 AM - 8:30 AM
FUNCTIONAL THROMBIN MODULATION IN VIVO BY PLATELET GLYCOPROTEIN IB
A. Zampolli* (US), J. R. Roberts, P. Marchese, Z. M. Ruggeri
OC-TU-045
8:30 AM - 8:45 AM
OXIDATIVE STRESS ACTIVATES ADAM17 (TACE) IN PLATELETS AND INDUCES GPIB-ALPHA SHEDDING IN A P38 KINASE-DEPENDENT FASHION
A. Brill* (US), A. K. Chauhan, M. Canault, M. T. Walsh, W. Bergmeier, D. D. Wagner
8:45 AM - 9:00 AM
ANTI- BETA2- GLYCOPROTEIN I ANTIBODIES DIRECTED TO DOMAIN I IN PATIENTS WITH ANTIPHOSPHOLIPID SYNDROME (APS) AND TRIPLE LABORATORY POSITIVITY
A. Banzato* (IT), N. Pozzi, V. Defilippis, E. Bison, M. Tonello, A. Ruffatti, V. Pengo
OC-TU-041
9:00 AM - 9:15 AM
COVALENTLY ASSOCIATED DIMERS AND MULTIMERS OF B2 GLYCOPROTEIN I
T. Matsui* (JP), A. Hayashi, Y. Yakura, S. Matsumoto, H. Takeya
OC-TU-042 9:15 AM - 9:30 AM
MODULATION OF KLF2 AND KLF4 BY ANTIPHOSPHOLIPID ANTIBODIES
K. L. Allen* (US), D. Kawanami, M. K. Jain, K. R. McCrae
Chairpersons: Joel Bennett (US) and Matthew Jones (UK)
OC-TU-043
8:00 AM - 8:15 AM
STRUCTURE OF THE GLYCOPROTEIN IB-BETA ECTODOMAIN
P. A. McEwan, X. Zheng, R. Li, J. Emsley* (UK)
OC-TU-044
8:15 AM - 8:30 AM
FUNCTIONAL THROMBIN MODULATION IN VIVO BY PLATELET GLYCOPROTEIN IB
A. Zampolli* (US), J. R. Roberts, P. Marchese, Z. M. Ruggeri
OC-TU-045
8:30 AM - 8:45 AM
OXIDATIVE STRESS ACTIVATES ADAM17 (TACE) IN PLATELETS AND INDUCES GPIB-ALPHA SHEDDING IN A P38 KINASE-DEPENDENT FASHION
A. Brill* (US), A. K. Chauhan, M. Canault, M. T. Walsh, W. Bergmeier, D. D. Wagner
OC-TU-046
8:45 AM - 9:00 AM
TRANS-SUBUNIT REGULATION OF ECTODOMAIN SHEDDING OF GLYCOPROTEIN IB-ALPHA
X. Mo* (US), N. X. Nguyen, H. Fan, M. C. Berndt, R. Li
8:45 AM - 9:00 AM
TRANS-SUBUNIT REGULATION OF ECTODOMAIN SHEDDING OF GLYCOPROTEIN IB-ALPHA
X. Mo* (US), N. X. Nguyen, H. Fan, M. C. Berndt, R. Li
OC-TU-047
9:00 AM - 9:15 AM
MEGAKARYOCYTES AND PLATELETS DIFFERENTIALLY EXPRESS AND SYNTHESIZE MMP/TIMP FAMILY MEMBERS
L. Cecchetti* (IT), N. Tolley, A. S. Weyrich, P. Gresele
9:00 AM - 9:15 AM
MEGAKARYOCYTES AND PLATELETS DIFFERENTIALLY EXPRESS AND SYNTHESIZE MMP/TIMP FAMILY MEMBERS
L. Cecchetti* (IT), N. Tolley, A. S. Weyrich, P. Gresele
OC-TU-048
9:15 AM - 9:30 AM
ACCELERATED THROMBOSIS IN A MOUSE MODEL WITH IMPAIRED MITOCHONDRIAL SIGNALING
S. M. Jobe* (US), W. Clemmons
Chairpersons: Victoria A. Ploplis (US) and Peter Panizzi (US)
9:15 AM - 9:30 AM
ACCELERATED THROMBOSIS IN A MOUSE MODEL WITH IMPAIRED MITOCHONDRIAL SIGNALING
S. M. Jobe* (US), W. Clemmons
Chairpersons: Victoria A. Ploplis (US) and Peter Panizzi (US)
OC-TU-049
8:00 AM - 8:15 AM
ATHEROSCLEROTIC LESIONS DEVELOPMENT IS NOT PREVENTED IN THE GPIBBETA-/-APOE-/- DOUBLE KNOCKOUT MICE
C. Strassel* (FR), B. Hechler, A. Bull, M. Freund, J. Cazenave, C. Gachet, F. Lanza
8:00 AM - 8:15 AM
ATHEROSCLEROTIC LESIONS DEVELOPMENT IS NOT PREVENTED IN THE GPIBBETA-/-APOE-/- DOUBLE KNOCKOUT MICE
C. Strassel* (FR), B. Hechler, A. Bull, M. Freund, J. Cazenave, C. Gachet, F. Lanza
OC-TU-050
8:15 AM - 8:30 AM
A PLASMINOGEN DEFICIENCY ATTENUATES ATHEROSCLEROSIS AS A RESULT OF ALTERED LIPOPROTEIN PROCESSING
T. Iwaki, D. L. Donahue, M. J. Sandoval-Cooper, F. J. Castellino, V. A. Ploplis* (US)
8:15 AM - 8:30 AM
A PLASMINOGEN DEFICIENCY ATTENUATES ATHEROSCLEROSIS AS A RESULT OF ALTERED LIPOPROTEIN PROCESSING
T. Iwaki, D. L. Donahue, M. J. Sandoval-Cooper, F. J. Castellino, V. A. Ploplis* (US)
OC-TU-051
8:30 AM - 8:45 AM
A SYNERGISTIC ROLE OF COMBINATION OF APOB AND HHSP60 EPITOPES IN REGRESSION OF ATHEROSCLEROTIC LESION
X. Lu* (UK), V. Endresz, M. Xia, D. Chen, G. Qi, I. Faludi, K. Burián, A. Csanadi, A. Miczák, E. Gonczol, V. Kakkar
8:30 AM - 8:45 AM
A SYNERGISTIC ROLE OF COMBINATION OF APOB AND HHSP60 EPITOPES IN REGRESSION OF ATHEROSCLEROTIC LESION
X. Lu* (UK), V. Endresz, M. Xia, D. Chen, G. Qi, I. Faludi, K. Burián, A. Csanadi, A. Miczák, E. Gonczol, V. Kakkar
OC-TU-052
8:45 AM - 9:00 AM
ALPHA-LINOLENIC ACID DIMINISHES ATHEROTHROMBOSIS, REDUCES RED CELL ARACHIDONIC ACID AND ENDOTHELIAL TISSUE FACTOR EXPRESSION
C. M. Matter, C. Lohmann, F. C. Tanner, E. W. Holy, E. K. Richter, F. Leiber, T. F. Lüscher, M. Forestier* (CH), J. H. Beer
8:45 AM - 9:00 AM
ALPHA-LINOLENIC ACID DIMINISHES ATHEROTHROMBOSIS, REDUCES RED CELL ARACHIDONIC ACID AND ENDOTHELIAL TISSUE FACTOR EXPRESSION
C. M. Matter, C. Lohmann, F. C. Tanner, E. W. Holy, E. K. Richter, F. Leiber, T. F. Lüscher, M. Forestier* (CH), J. H. Beer
OC-TU-053
9:00 AM - 9:15 AM
WARFARIN INDUCES VASCULAR CALCIFICATION AS AN UNWANTED SIDE-EFFECT
L. J. Schurgers* (NL), R. Westenfeld, T. Krueger, S. Oelenberg, C. Vermeer, C. P. Reutelingsperger
9:00 AM - 9:15 AM
WARFARIN INDUCES VASCULAR CALCIFICATION AS AN UNWANTED SIDE-EFFECT
L. J. Schurgers* (NL), R. Westenfeld, T. Krueger, S. Oelenberg, C. Vermeer, C. P. Reutelingsperger
OC-TU-054
9:15 AM - 9:30 AM
TISSUE TRANSGLUTAMINASE IS NOT ESSENTIAL FOR ARTERIAL CALCIFICATION IN THE APOLIPOPROTEIN E KNOCKOUT MOUSE
R. J. Pease* (UK), H. Williams, R. M. Graham, C. L. Jackson, P. J. Grant
Chairpersons: Benjamin Brenner (IL) and Rienk Nieuwland (NL)
9:15 AM - 9:30 AM
TISSUE TRANSGLUTAMINASE IS NOT ESSENTIAL FOR ARTERIAL CALCIFICATION IN THE APOLIPOPROTEIN E KNOCKOUT MOUSE
R. J. Pease* (UK), H. Williams, R. M. Graham, C. L. Jackson, P. J. Grant
Chairpersons: Benjamin Brenner (IL) and Rienk Nieuwland (NL)
OC-TU-055
8:00 AM - 8:15 AM
CASPASE 3 IS SORTED INTO MICROPARTICLES FROM MCF-7 CELLS
A. N. Böing* (NL), G. B. Afink, C. Ris, A. Sturk, R. Nieuwland
8:00 AM - 8:15 AM
CASPASE 3 IS SORTED INTO MICROPARTICLES FROM MCF-7 CELLS
A. N. Böing* (NL), G. B. Afink, C. Ris, A. Sturk, R. Nieuwland
OC-TU-056
8:15 AM - 8:30 AM
APPLICATION OF DYNAMIC LIGHT SCATTERING TO THE MEASUREMENT OF MICROPARTICLES
P. Harrison* (UK), R. Dragovic, A. Albanyan, A. S. Lawrie, M. Murphy, I. Sargent
8:15 AM - 8:30 AM
APPLICATION OF DYNAMIC LIGHT SCATTERING TO THE MEASUREMENT OF MICROPARTICLES
P. Harrison* (UK), R. Dragovic, A. Albanyan, A. S. Lawrie, M. Murphy, I. Sargent
OC-TU-057
8:30 AM - 8:45 AM
THE ROLE OF MICROPARTICLES (MPS) IN DIABETIC VASCULAR COMPLICATIONS
A. Aharon* (IL), G. Tsimerman, A. Rugin, E. Melamed, A. Bachar, B. Brenner
8:30 AM - 8:45 AM
THE ROLE OF MICROPARTICLES (MPS) IN DIABETIC VASCULAR COMPLICATIONS
A. Aharon* (IL), G. Tsimerman, A. Rugin, E. Melamed, A. Bachar, B. Brenner
OC-TU-058
8:45 AM - 9:00 AM
MICROPARTICLES AFFECT ANGIOGENESIS AND INFLAMMATION BALANCE– IN HEALTHY PREGNANCIES AND GESTATIONAL VASCULAR COMPLICATIONS
A. Aharon* (IL), E. Shomer, S. Katzenell, B. Brenner
8:45 AM - 9:00 AM
MICROPARTICLES AFFECT ANGIOGENESIS AND INFLAMMATION BALANCE– IN HEALTHY PREGNANCIES AND GESTATIONAL VASCULAR COMPLICATIONS
A. Aharon* (IL), E. Shomer, S. Katzenell, B. Brenner
OC-TU-059
9:00 AM - 9:15 AM
CIRCULATING ERYTHROCYTE-DERIVED MICROPARTICLES ARE ASSOCIATED WITH COAGULATION ACTIVATION IN SICKLE CELL DISEASE
E. J. van Beers* (NL), M. C. L. Schaap, R. J. Berckmans, R. Nieuwland, A. Sturk, F. F. van Doormaal, J. C. M. Meijers, B. J. Biemond
9:00 AM - 9:15 AM
CIRCULATING ERYTHROCYTE-DERIVED MICROPARTICLES ARE ASSOCIATED WITH COAGULATION ACTIVATION IN SICKLE CELL DISEASE
E. J. van Beers* (NL), M. C. L. Schaap, R. J. Berckmans, R. Nieuwland, A. Sturk, F. F. van Doormaal, J. C. M. Meijers, B. J. Biemond
OC-TU-060
9:15 AM - 9:30 AM
PROTEOMICS OF HUMAN MICROPARTICLES AFTER DEEP VENOUS THROMBOSIS
E. Ramacciotti* (US), A. E. Hawley, S. K. Wrobleski, D. D. Myers Jr, J. R. Strahler, P. C. Andrew, P. K. Henke, T. W. Wakefield
Chairpersons: Marilyn Manco-Johnson (US) and Susanne Holzhauer (DE)
9:15 AM - 9:30 AM
PROTEOMICS OF HUMAN MICROPARTICLES AFTER DEEP VENOUS THROMBOSIS
E. Ramacciotti* (US), A. E. Hawley, S. K. Wrobleski, D. D. Myers Jr, J. R. Strahler, P. C. Andrew, P. K. Henke, T. W. Wakefield
Chairpersons: Marilyn Manco-Johnson (US) and Susanne Holzhauer (DE)
OC-TU-061
8:00 AM - 8:15 AM
INCIDENCE AND RISK FACTORS OF CATHETER-RELATED ARTERIAL THROMBOSIS IN CHILDREN
M. Albisetti* (CH), B. Brotschi, D. Neuhaus, C. Bürki, B. Latal, W. Knirsch, O. Kretschmar, S. Kroiss, M. Schmugge, M. Hug
8:00 AM - 8:15 AM
INCIDENCE AND RISK FACTORS OF CATHETER-RELATED ARTERIAL THROMBOSIS IN CHILDREN
M. Albisetti* (CH), B. Brotschi, D. Neuhaus, C. Bürki, B. Latal, W. Knirsch, O. Kretschmar, S. Kroiss, M. Schmugge, M. Hug
OC-TU-062
8:15 AM - 8:30 AM
PREVALENCE OF THROMBOPHILIA AND INCIDENCE OF SYMPTOMATIC THROMBOEMBOLISM IN FIRST DEGREE RELATIVES OF PEDIATRIC INDEX CASES: A PROSPECTIVE COHORT STUDY
S. Holzhauer* (DE), M. Stoll, S. Thedieck, A. Huge, G. de Angelis, D. Manner, R. Mesters, U. Nowak-Göttl
8:15 AM - 8:30 AM
PREVALENCE OF THROMBOPHILIA AND INCIDENCE OF SYMPTOMATIC THROMBOEMBOLISM IN FIRST DEGREE RELATIVES OF PEDIATRIC INDEX CASES: A PROSPECTIVE COHORT STUDY
S. Holzhauer* (DE), M. Stoll, S. Thedieck, A. Huge, G. de Angelis, D. Manner, R. Mesters, U. Nowak-Göttl
OC-TU-063
8:30 AM - 8:45 AM
NEONATAL SINOVENOUS THROMBOSIS: CLINICAL PRESENTATION, RISKFACTORS, IMAGING RESULTS, OUTCOME
F. J. Berfelo* (NL), T. R. de Haan, F. Groenendaal, L. S. de Vries, P. Govaert, C. van Ommen
OC-TU-064
8:45 AM - 9:00 AM
ANTIPHOSPHOLIPID SYNDROME (APS) IN A PEDIATRIC COHORT WITH VENOUS THROMBOEMBOLISM
M. Bonduel* (AR), M. Hepner, G. Sciuccati, G. Pieroni, S. E. Annetta, A. Feliú-Torres, M. Castañon, J. Frontroth
OC-TU-065
9:00 AM - 9:15 AM
INCIDENCE AND RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN CRITICALLY ILL CHILDREN WITH CARDIAC DISEASE
S. J. Hanson* (US), R. C. Punzalan, N. S. Ghanayem, P. L. Havens
8:30 AM - 8:45 AM
NEONATAL SINOVENOUS THROMBOSIS: CLINICAL PRESENTATION, RISKFACTORS, IMAGING RESULTS, OUTCOME
F. J. Berfelo* (NL), T. R. de Haan, F. Groenendaal, L. S. de Vries, P. Govaert, C. van Ommen
OC-TU-064
8:45 AM - 9:00 AM
ANTIPHOSPHOLIPID SYNDROME (APS) IN A PEDIATRIC COHORT WITH VENOUS THROMBOEMBOLISM
M. Bonduel* (AR), M. Hepner, G. Sciuccati, G. Pieroni, S. E. Annetta, A. Feliú-Torres, M. Castañon, J. Frontroth
OC-TU-065
9:00 AM - 9:15 AM
INCIDENCE AND RISK FACTORS FOR VENOUS THROMBOEMBOLISM IN CRITICALLY ILL CHILDREN WITH CARDIAC DISEASE
S. J. Hanson* (US), R. C. Punzalan, N. S. Ghanayem, P. L. Havens
OC-TU-066
9:15 AM - 9:30 AM
WARFARIN THERAPY INDUCED COAGULOPATHY IN CHILDREN: ASSESSMENT OF A CONSERVATIVE APPROACH
K. L. Black, M. E. Bauman, S. Kuhle, L. Bajzar, M. P. Massicotte* (CA)
Chairpersons: Michael Makris (UK) and Evelyn Groot (NL)
OC-TU-067
8:00 AM - 8:15 AM
QUANTIFICATION OF LOW LEVELS OF FUNCTIONAL FACTOR VIII IN PLASMA BY TURBIDITY
P. Y. Kim* (CA), A. C. Ma, V. A. Ward, M. E. Nesheim
OC-TU-068
8:15 AM - 8:30 AM
DOES HETEROGENEITY IN MEASURED CALIBRATED THROMBIN GENERATION ASSAY OR FVIII ACTIVITY (<1%) EXPLAIN CLINICAL HETEROGENEITY IN SEVERE HEMOPHILIA A?
G. D. Sinclair* (CA), V. Blanchette, R. T. Card, A. K. C. Chan, S. Israels, D. Lillicrap, G. Rivard, S. Robinson, L. Vickars, Z. Williams, J. K. M. Wu, M. Poon
OC-TU-069
8:30 AM - 8:45 AM
TAFI ACTIVATION IN THE WHOLE BLOOD OF PATIENTS WITH HEMOPHILIA A
J. H. Foley* (CA), M. E. Nesheim, G. E. Rivard, K. E. Brummel-Ziedins
OC-TU-070
8:45 AM - 9:00 AM
PREDICTED FREQUENCY OF JOINT BLEEDS BASED ON RESIDUAL CLOTTING FACTOR LEVELS
I. E. M. den Uijl* (NL), K. Fischer, J. G. van der Bom, D. E. Grobbee, F. R. Rosendaal, I. Plug
9:15 AM - 9:30 AM
WARFARIN THERAPY INDUCED COAGULOPATHY IN CHILDREN: ASSESSMENT OF A CONSERVATIVE APPROACH
K. L. Black, M. E. Bauman, S. Kuhle, L. Bajzar, M. P. Massicotte* (CA)
Chairpersons: Michael Makris (UK) and Evelyn Groot (NL) OC-TU-067
8:00 AM - 8:15 AM
QUANTIFICATION OF LOW LEVELS OF FUNCTIONAL FACTOR VIII IN PLASMA BY TURBIDITY
P. Y. Kim* (CA), A. C. Ma, V. A. Ward, M. E. Nesheim
OC-TU-068
8:15 AM - 8:30 AM
DOES HETEROGENEITY IN MEASURED CALIBRATED THROMBIN GENERATION ASSAY OR FVIII ACTIVITY (<1%) EXPLAIN CLINICAL HETEROGENEITY IN SEVERE HEMOPHILIA A?
G. D. Sinclair* (CA), V. Blanchette, R. T. Card, A. K. C. Chan, S. Israels, D. Lillicrap, G. Rivard, S. Robinson, L. Vickars, Z. Williams, J. K. M. Wu, M. Poon
OC-TU-069
8:30 AM - 8:45 AM
TAFI ACTIVATION IN THE WHOLE BLOOD OF PATIENTS WITH HEMOPHILIA A
J. H. Foley* (CA), M. E. Nesheim, G. E. Rivard, K. E. Brummel-Ziedins
OC-TU-070
8:45 AM - 9:00 AM
PREDICTED FREQUENCY OF JOINT BLEEDS BASED ON RESIDUAL CLOTTING FACTOR LEVELS
I. E. M. den Uijl* (NL), K. Fischer, J. G. van der Bom, D. E. Grobbee, F. R. Rosendaal, I. Plug
OC-TU-071
9:00 AM - 9:15 AM
FUNCTIONAL ASSAYS FOR THE DISCRIMINATION OF TYPE 2 VWD VARIANTS
V. H. Flood* (US), P. A. Morateck, P. A. Christopherson, J. C. Gill, K. D. Friedman, R. R. Montgomery
9:00 AM - 9:15 AM
FUNCTIONAL ASSAYS FOR THE DISCRIMINATION OF TYPE 2 VWD VARIANTS
V. H. Flood* (US), P. A. Morateck, P. A. Christopherson, J. C. Gill, K. D. Friedman, R. R. Montgomery
OC-TU-072
9:15 AM - 9:30 AM
NANOBODY AU/VWF-A11: AN ADDITIONAL TOOL FOR A BETTER CHARACTERIZATION OF DIFFERENT TYPES OF VON WILLEBRAND DISEASE
E. Groot* (NL), A. B. Federici, M. Solimando, M. Punzo, P. J. Lenting, F. Rezzonico, L. Baronciani, P. G. de Groot
Chairpersons: David Lillicrap (CA) and Daniel Hampshire (UK)
9:15 AM - 9:30 AM
NANOBODY AU/VWF-A11: AN ADDITIONAL TOOL FOR A BETTER CHARACTERIZATION OF DIFFERENT TYPES OF VON WILLEBRAND DISEASE
E. Groot* (NL), A. B. Federici, M. Solimando, M. Punzo, P. J. Lenting, F. Rezzonico, L. Baronciani, P. G. de Groot
Chairpersons: David Lillicrap (CA) and Daniel Hampshire (UK)
OC-TU-073
8:00 AM - 8:15 AM
STUDY OF 7 LARGE DELETIONS OF BEGINNING OR END OF F8 GENE IN SEVERE HEMOPHILIA A PATIENTS
R. Chatelain, M. Fretigny, H. Chambost, J. Goudemand, C. Zawadzki, B. Guillet, Y. Gruel, T. Lambert, C. Negrier, C. Vinciguerra* (FR)
8:00 AM - 8:15 AM
STUDY OF 7 LARGE DELETIONS OF BEGINNING OR END OF F8 GENE IN SEVERE HEMOPHILIA A PATIENTS
R. Chatelain, M. Fretigny, H. Chambost, J. Goudemand, C. Zawadzki, B. Guillet, Y. Gruel, T. Lambert, C. Negrier, C. Vinciguerra* (FR)
OC-TU-074
8:15 AM - 8:30 AM
FVIII MRNA ANALYSIS IN MILD HEMOPHILIA A PATIENTS WITH SPLICE SITE CHANGES OR WITHOUT GENOMIC MUTATIONS
S. Sanna, S. Giacomelli, M. Mancuso, E. Santagostino, P. Mannucci, F. Rodeghiero, G. Castaman* (IT)
8:15 AM - 8:30 AM
FVIII MRNA ANALYSIS IN MILD HEMOPHILIA A PATIENTS WITH SPLICE SITE CHANGES OR WITHOUT GENOMIC MUTATIONS
S. Sanna, S. Giacomelli, M. Mancuso, E. Santagostino, P. Mannucci, F. Rodeghiero, G. Castaman* (IT)
OC-TU-075
8:30 AM - 8:45 AM
FACTOR VIII GENE (F8) MUTATIONS AS A PREDICTOR OF OUTCOME IN IMMUNE TOLERANCE INDUCTION (ITI) IN HEMOPHILIA A PATIENTS WITH HIGH-RESPONDING INHIBITORS
A. Coppola* (IT), M. Margaglione, E. Santagostino, A. Rocino, F. Scaraggi, A. Tagliaferri, G. Castaman, M. Messina, M. E. Mancuso, A. Iorio, P. Schinco, E. Zanon, R. Musso, G. Mancuso, G. di Minno, P. Mannucci
8:30 AM - 8:45 AM
FACTOR VIII GENE (F8) MUTATIONS AS A PREDICTOR OF OUTCOME IN IMMUNE TOLERANCE INDUCTION (ITI) IN HEMOPHILIA A PATIENTS WITH HIGH-RESPONDING INHIBITORS
A. Coppola* (IT), M. Margaglione, E. Santagostino, A. Rocino, F. Scaraggi, A. Tagliaferri, G. Castaman, M. Messina, M. E. Mancuso, A. Iorio, P. Schinco, E. Zanon, R. Musso, G. Mancuso, G. di Minno, P. Mannucci
OC-TU-076
8:45 AM - 9:00 AM
FUNCTIONAL CHARACTERISATION OF 13-BP DELETION MUTATION (-1255 DEL) IN THE VWF GENE PROMOTER CAUSING TYPE 1 VON WILLEBRAND DISEASE
M. Othman* (CA), Y. Chirinian, C. Brown, C. Notely, S. Buckley, S. N. Waddington, A. H. Baker, D. Lillicrap
8:45 AM - 9:00 AM
FUNCTIONAL CHARACTERISATION OF 13-BP DELETION MUTATION (-1255 DEL) IN THE VWF GENE PROMOTER CAUSING TYPE 1 VON WILLEBRAND DISEASE
M. Othman* (CA), Y. Chirinian, C. Brown, C. Notely, S. Buckley, S. N. Waddington, A. H. Baker, D. Lillicrap
OC-TU-077
9:00 AM - 9:15 AM
IDENTIFICATION OF THREE ADDITIONAL MUTATIONS IN PATIENTS ENROLLED IN THE EUROPEAN STUDY, MOLECULAR AND CLINICAL MARKERS FOR THE DIAGNOSIS AND MANAGEMENT OF TYPE 1 VWD (MCMDM-1VWD)
G. J. Burghel, J. C. J. Eikenboom, R. Schneppenheim, U. Budde, I. R. Peake, A. C. Goodeve, D. J. Hampshire* (UK), on behalf of the EU-VWD Study Group
9:00 AM - 9:15 AM
IDENTIFICATION OF THREE ADDITIONAL MUTATIONS IN PATIENTS ENROLLED IN THE EUROPEAN STUDY, MOLECULAR AND CLINICAL MARKERS FOR THE DIAGNOSIS AND MANAGEMENT OF TYPE 1 VWD (MCMDM-1VWD)
G. J. Burghel, J. C. J. Eikenboom, R. Schneppenheim, U. Budde, I. R. Peake, A. C. Goodeve, D. J. Hampshire* (UK), on behalf of the EU-VWD Study Group
OC-TU-078
9:15 AM - 9:30 AM
TYPE 1 AND TYPE 3 VON WILLEBRAND DISEASE ASSOCIATED WITH A NOVEL RECURRENT DELETION MUTATION
M. S. Sutherland, A. M. Cumming, M. Bowman, P. H. B. Bolton-Maggs, D. J. Bowen, P. W. Collins, C. R. M. Hay, A. Will, S. Keeney* (UK)
Chairpersons: Bernard LeBonniec (FR) and Daniel Johnson (UK)
9:15 AM - 9:30 AM
TYPE 1 AND TYPE 3 VON WILLEBRAND DISEASE ASSOCIATED WITH A NOVEL RECURRENT DELETION MUTATION
M. S. Sutherland, A. M. Cumming, M. Bowman, P. H. B. Bolton-Maggs, D. J. Bowen, P. W. Collins, C. R. M. Hay, A. Will, S. Keeney* (UK)
Chairpersons: Bernard LeBonniec (FR) and Daniel Johnson (UK)
OC-TU-079
8:00 AM - 8:15 AM
POINT MUTATIONS IN PROTEIN Z DEPENDENT PROTEASE INHIBITOR IMPAIR INHIBITORY FUNCTION
L. Young, N. van de Water, P. Ockelford, A. Horvath, P. Coughlin, P. Browett, N. Birch, P. L. Harper* (NZ)
8:00 AM - 8:15 AM
POINT MUTATIONS IN PROTEIN Z DEPENDENT PROTEASE INHIBITOR IMPAIR INHIBITORY FUNCTION
L. Young, N. van de Water, P. Ockelford, A. Horvath, P. Coughlin, P. Browett, N. Birch, P. L. Harper* (NZ)
OC-TU-080
8:15 AM - 8:30 AM
CITRULLINATION OF ANTITHROMBIN: PROTEOMIC CHARACTERIZATI ON AND CORRELATION WITH FUNCTIONAL AND CONFORMATIONAL EFFECTS
A. Ordóñez* (ES), F. J. Corrales, I. Martínez-Martínez, C. Miqueo, A. Miñano, V. Vicente, J. Corral
8:15 AM - 8:30 AM
CITRULLINATION OF ANTITHROMBIN: PROTEOMIC CHARACTERIZATI ON AND CORRELATION WITH FUNCTIONAL AND CONFORMATIONAL EFFECTS
A. Ordóñez* (ES), F. J. Corrales, I. Martínez-Martínez, C. Miqueo, A. Miñano, V. Vicente, J. Corral
OC-TU-081
8:30 AM - 8:45 AM
INTRACELLULAR INTERACTION PARTNERS OF PROTEIN C INHIBITOR (PCI)
M. Furtmüller* (AT), B. Sokolikova, F. Wahlmüller, J. Schmid, H. Linder, B. Binder, M. Geiger
8:30 AM - 8:45 AM
INTRACELLULAR INTERACTION PARTNERS OF PROTEIN C INHIBITOR (PCI)
M. Furtmüller* (AT), B. Sokolikova, F. Wahlmüller, J. Schmid, H. Linder, B. Binder, M. Geiger
OC-TU-082
8:45 AM - 9:00 AM
ANTITHROMBIN MURCIA (K241E) REVEALS A NEW MECHANISM FOR ANTITHROMBIN DEFICIENCY INDIRECTLY AFFECTING GLYCOSYLATION
I. Martínez-Martínez* (ES), A. Ordóñez, J. Navarro-Fernández, Á. Pérez-Lara, R. Gutiérrez-Gallego, R. Giraldo, C. Martínez, E. Llop, V. Vicente, J. Corral
8:45 AM - 9:00 AM
ANTITHROMBIN MURCIA (K241E) REVEALS A NEW MECHANISM FOR ANTITHROMBIN DEFICIENCY INDIRECTLY AFFECTING GLYCOSYLATION
I. Martínez-Martínez* (ES), A. Ordóñez, J. Navarro-Fernández, Á. Pérez-Lara, R. Gutiérrez-Gallego, R. Giraldo, C. Martínez, E. Llop, V. Vicente, J. Corral
OC-TU-083
9:00 AM - 9:15 AM
SURFACE EXPOSED LYSINE RESIDUES, BUT NOT ARGININE RESIDUES, CONTRIBUTE TO LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN INTERACTION
M. van den Biggelaar* (NL), J. W. T. M. Klein Gebbinck, K. Mertens, A. B. Meijer
9:00 AM - 9:15 AM
SURFACE EXPOSED LYSINE RESIDUES, BUT NOT ARGININE RESIDUES, CONTRIBUTE TO LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN INTERACTION
M. van den Biggelaar* (NL), J. W. T. M. Klein Gebbinck, K. Mertens, A. B. Meijer
OC-TU-084
9:15 AM - 9:30 AM
LYSINE RESIDUES IN THE ANTIPLASMIN C-TERMINUS MEDIATE ONLY A PART OF THE INTERACTION WITH PLASMIN
B. Lu, T. Sofian, P. B. Coughlin* (AU), A. Horvath
Chairpersons: Francoise Dignat-George (FR) and Michael Tomlinson (UK)
9:15 AM - 9:30 AM
LYSINE RESIDUES IN THE ANTIPLASMIN C-TERMINUS MEDIATE ONLY A PART OF THE INTERACTION WITH PLASMIN
B. Lu, T. Sofian, P. B. Coughlin* (AU), A. Horvath
Chairpersons: Francoise Dignat-George (FR) and Michael Tomlinson (UK)
OC-TU-085
8:00 AM - 8:15 AM
MARKERS OF ENDOTHELIAL FUNCTION IN LACUNAR STROKE
I. L. H. Knottnerus* (NL), H. ten Cate, J. W. P. Govers-Riemslag, R. van Oerle, R. P. W. Rouhl, J. Staals, H. M. H. Spronk, J. Lodder, R. van Oostenbrugge
8:00 AM - 8:15 AM
MARKERS OF ENDOTHELIAL FUNCTION IN LACUNAR STROKE
I. L. H. Knottnerus* (NL), H. ten Cate, J. W. P. Govers-Riemslag, R. van Oerle, R. P. W. Rouhl, J. Staals, H. M. H. Spronk, J. Lodder, R. van Oostenbrugge
OC-TU-086
8:15 AM - 8:30 AM
THROMBIN GENARATION AND MICROPARTICLES PLASMA LEVELS IN PATIENTS WITH VASCULITIS
M. Castelli, L. Spiezia* (IT), V. Rossetto, V. Carraro, C. Radu, F. Schiavon, S. Todesco, A. Pagnan, P. Simioni
8:15 AM - 8:30 AM
THROMBIN GENARATION AND MICROPARTICLES PLASMA LEVELS IN PATIENTS WITH VASCULITIS
M. Castelli, L. Spiezia* (IT), V. Rossetto, V. Carraro, C. Radu, F. Schiavon, S. Todesco, A. Pagnan, P. Simioni
OC-TU-087
8:30 AM - 8:45 AM
INCREASED LEVELS OF MICROPARTICLES ORIGINATING FROM ENDOTHELIUM, PLATELET AND ERYTHROCYTE IN SUBJECTS WITH METABOLIC SYNDROME: RELATIONSHIP WITH OXIDATIVE STRESS
O. Helal, C. Defoort, S. Robert, C. Marin, N. Lesavre, J. Lopez-Miranda, U. Riserus, S. Basu, J. Lovegrove, J. McMonagle, F. Sabatier, H. Roche, D. Lairon, F. Dignat-George* (FR)
8:30 AM - 8:45 AM
INCREASED LEVELS OF MICROPARTICLES ORIGINATING FROM ENDOTHELIUM, PLATELET AND ERYTHROCYTE IN SUBJECTS WITH METABOLIC SYNDROME: RELATIONSHIP WITH OXIDATIVE STRESS
O. Helal, C. Defoort, S. Robert, C. Marin, N. Lesavre, J. Lopez-Miranda, U. Riserus, S. Basu, J. Lovegrove, J. McMonagle, F. Sabatier, H. Roche, D. Lairon, F. Dignat-George* (FR)
OC-TU-088
8:45 AM - 9:00 AM
DECREASED PLASMA SOLUBLE RAGE IN PATIENTS WITH HYPERCHOLESTEROLEMIA: EFFECTS OF STATINS
N. Vazzana* (IT), F. Santilli, L. G. Bucciarelli, D. Noto, A. B. Cefalù, V. Davì, E. Ferrante, C. Pettinella, M. Averna, G. Ciabattoni, G. Davì
8:45 AM - 9:00 AM
DECREASED PLASMA SOLUBLE RAGE IN PATIENTS WITH HYPERCHOLESTEROLEMIA: EFFECTS OF STATINS
N. Vazzana* (IT), F. Santilli, L. G. Bucciarelli, D. Noto, A. B. Cefalù, V. Davì, E. Ferrante, C. Pettinella, M. Averna, G. Ciabattoni, G. Davì
OC-TU-089
9:00 AM - 9:15 AM
IMPACT OF IMMUNOSUPPRESSIVE TREATMENT ON ENDOTHELIAL BIOMARKERS AFTER KIDNEY TRANSPLANTATION
L. Camoin-Jau* (FR), H. Vacher Coponat, P. Paul, L. Arnaud, S. Robert, Y. Berland, F. Dignat George
9:00 AM - 9:15 AM
IMPACT OF IMMUNOSUPPRESSIVE TREATMENT ON ENDOTHELIAL BIOMARKERS AFTER KIDNEY TRANSPLANTATION
L. Camoin-Jau* (FR), H. Vacher Coponat, P. Paul, L. Arnaud, S. Robert, Y. Berland, F. Dignat George
OC-TU-090
9:15 AM - 9:30 AM
IMBALANCE BETWEEN CIRCULATING ENDOTHELIAL CELLS AND PROGENITORS IN PRIMITIVE AND POST EMBOLIC PULMONARY HYPERTENSION
D. M. Smadja* (FR), L. Mauge, D. Israel-Biet, P. Gaussem, O. Sanchez
Chairpersons: Gary Gilbert (US) and Rinku Majumder (US)
9:15 AM - 9:30 AM
IMBALANCE BETWEEN CIRCULATING ENDOTHELIAL CELLS AND PROGENITORS IN PRIMITIVE AND POST EMBOLIC PULMONARY HYPERTENSION
D. M. Smadja* (FR), L. Mauge, D. Israel-Biet, P. Gaussem, O. Sanchez
Chairpersons: Gary Gilbert (US) and Rinku Majumder (US)
OC-TU-091
8:00 AM - 8:15 AM
SOLID-STATE NMR STUDIES OF NANOSCALE PHOSPHOLIPID BILAYERS USING ISOTOPICALLY-LABELED PHOSPHATIDYLSERINE
R. L. Davis-Harrison* (US), J. M. Boettcher, A. J. Nieuwkoop, A. Z. Kijac, S. G. Sligar, C. M. Rienstra, J. H. Morrissey
8:00 AM - 8:15 AM
SOLID-STATE NMR STUDIES OF NANOSCALE PHOSPHOLIPID BILAYERS USING ISOTOPICALLY-LABELED PHOSPHATIDYLSERINE
R. L. Davis-Harrison* (US), J. M. Boettcher, A. J. Nieuwkoop, A. Z. Kijac, S. G. Sligar, C. M. Rienstra, J. H. Morrissey
OC-TU-092
8:15 AM - 8:30 AM
UNIQUE STRUCTURAL MODELS OF PROTHROMBINASE ASSEMBLED ON THE ACTIVATED PLATELET MEMBRANE
A. M. Fager* (US), P. B. Tracy, S. J. Everse
8:15 AM - 8:30 AM
UNIQUE STRUCTURAL MODELS OF PROTHROMBINASE ASSEMBLED ON THE ACTIVATED PLATELET MEMBRANE
A. M. Fager* (US), P. B. Tracy, S. J. Everse
OC-TU-093
8:30 AM - 8:45 AM
NEW INSIGHT INTO THE ROLE OF MEMBRANE IN THE PROTHROMBINASE COMPLEX
S. H. Qureshi* (US), L. Yang, C. Manithody, A. R. Rezaie
8:30 AM - 8:45 AM
NEW INSIGHT INTO THE ROLE OF MEMBRANE IN THE PROTHROMBINASE COMPLEX
S. H. Qureshi* (US), L. Yang, C. Manithody, A. R. Rezaie
OC-TU-094
8:45 AM - 9:00 AM
DYNAMICAL VIEW OF MEMBRANE BINDING AND COMPLEX FORMATION OF HUMAN TISSUE FACTOR AND FACTOR VIIa
E. Tajkhorshid* (US), Y. Z. Ohkubo
8:45 AM - 9:00 AM
DYNAMICAL VIEW OF MEMBRANE BINDING AND COMPLEX FORMATION OF HUMAN TISSUE FACTOR AND FACTOR VIIa
E. Tajkhorshid* (US), Y. Z. Ohkubo
OC-TU-095
9:00 AM - 9:15 AM
DYNAMICS OF FACTOR VIII C2 DOMAIN IN RELATION TO MEMBRANE BINDING
D. Pantazatos* (US), C. R. Gessner, V. L. Woods, G. E. Gilbert
9:00 AM - 9:15 AM
DYNAMICS OF FACTOR VIII C2 DOMAIN IN RELATION TO MEMBRANE BINDING
D. Pantazatos* (US), C. R. Gessner, V. L. Woods, G. E. Gilbert
OC-TU-096
9:15 AM - 9:30 AM
ANIONIC PHOSPHOLIPIDS LOSE THEIR PROCOAGULANT PROPERTIES WHEN INCORPORATED INTO HIGH-DENSITY LIPOPROTEINS
C. Oslakovic* (SE), M. J. Krisinger, A. Andersson, M. Jauhiainen, C. Ehnholm, B. Dahlbäck
9:15 AM - 9:30 AM
ANIONIC PHOSPHOLIPIDS LOSE THEIR PROCOAGULANT PROPERTIES WHEN INCORPORATED INTO HIGH-DENSITY LIPOPROTEINS
C. Oslakovic* (SE), M. J. Krisinger, A. Andersson, M. Jauhiainen, C. Ehnholm, B. Dahlbäck