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Oral Communications
* Presenting Author
Chairpersons: Sam Schulman (CA) and Robert Giugliano (US)
OC-WE-001
8:00 AM - 8:15 AM
EFFICACY AND SAFETY OF FONDAPARINUX IN THE INITIAL TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) IN PATIENTS AGED 75 YEARS OR ABOVE
H. R. Buller* (NL)
8:00 AM - 8:15 AM
EFFICACY AND SAFETY OF FONDAPARINUX IN THE INITIAL TREATMENT OF VENOUS THROMBOEMBOLISM (VTE) IN PATIENTS AGED 75 YEARS OR ABOVE
H. R. Buller* (NL)
OC-WE-002
8:15 AM - 8:30 AM
FONDAPARINUX 1.5 MG IN PATIENTS WITH MODERATE TO SEVERE RENAL IMPAIRMENT UNDERGOING MAJOR ORTHOPEDIC SURGERY: THE PROPICE STUDY
P. Mismetti* (FR), N. Rosencher, C. Samama, C. Vielpeau, P. Nguyen, B. Deygas, E. Presles, S. Laporte
8:15 AM - 8:30 AM
FONDAPARINUX 1.5 MG IN PATIENTS WITH MODERATE TO SEVERE RENAL IMPAIRMENT UNDERGOING MAJOR ORTHOPEDIC SURGERY: THE PROPICE STUDY
P. Mismetti* (FR), N. Rosencher, C. Samama, C. Vielpeau, P. Nguyen, B. Deygas, E. Presles, S. Laporte
OC-WE-003
8:30 AM - 8:45 AM
THE RELATIONSHIP BETWEEN ORAL FACTOR Xa (FXa) INHIBITOR DU-176B PHARMACOKINETICS (PK) AND THE PROBABILITY OF BLEEDING EVENTS (BE) IN PATIENTS WITH ATRIAL FIBRILLATION (AF)
R. Giugliano* (US), S. Rohatagi, H. Kastrissios, M. Green, T. J. Carrothers, J. Mendell, E. Antman, D. Salazar
8:30 AM - 8:45 AM
THE RELATIONSHIP BETWEEN ORAL FACTOR Xa (FXa) INHIBITOR DU-176B PHARMACOKINETICS (PK) AND THE PROBABILITY OF BLEEDING EVENTS (BE) IN PATIENTS WITH ATRIAL FIBRILLATION (AF)
R. Giugliano* (US), S. Rohatagi, H. Kastrissios, M. Green, T. J. Carrothers, J. Mendell, E. Antman, D. Salazar
OC-WE-004
8:45 AM - 9:00 AM
POOLED ANALYSIS OF FOUR RIVAROXABAN STUDIES: EFFECTS ON SYMPTOMATIC EVENTS AND BLEEDING
A. G. G. Turpie* (CA), M. R. Lassen, A. K. Kakkar, B. I. Eriksson, M. Gent
8:45 AM - 9:00 AM
POOLED ANALYSIS OF FOUR RIVAROXABAN STUDIES: EFFECTS ON SYMPTOMATIC EVENTS AND BLEEDING
A. G. G. Turpie* (CA), M. R. Lassen, A. K. Kakkar, B. I. Eriksson, M. Gent
OC-WE-005
9:00 AM - 9:15 AM
ECONOMIC COMPARISON OF RIVAROXABAN WITH DABIGATRAN IN CANADIAN PATIENTS UNDERGOING TOTAL HIP REPLACEMENT
P. Wells* (CA), A. Diamantopoulos, H. McDonald, F. Forster, C. Lereun, F. Rasul, M. Lees
9:00 AM - 9:15 AM
ECONOMIC COMPARISON OF RIVAROXABAN WITH DABIGATRAN IN CANADIAN PATIENTS UNDERGOING TOTAL HIP REPLACEMENT
P. Wells* (CA), A. Diamantopoulos, H. McDonald, F. Forster, C. Lereun, F. Rasul, M. Lees
OC-WE-006
9:15 AM - 9:30 AM
REVERSIBILITY OF THE ANTICOAGULANT ACTIVITY OF IDRABIOTAPARINUX (BIOTINYLATED IDRAPARINUX) BY AVIDIN IN HEALTHY SUBJECTS AND PATIENTS
I. Paty* (FR), M. Trellu, J. Destors, P. Cortez, E. Boëlle, G. Sanderink
Chairpersons: Toshiyuki Miyata (JP) and X. Long Zheng (US)
9:15 AM - 9:30 AM
REVERSIBILITY OF THE ANTICOAGULANT ACTIVITY OF IDRABIOTAPARINUX (BIOTINYLATED IDRAPARINUX) BY AVIDIN IN HEALTHY SUBJECTS AND PATIENTS
I. Paty* (FR), M. Trellu, J. Destors, P. Cortez, E. Boëlle, G. Sanderink
Chairpersons: Toshiyuki Miyata (JP) and X. Long Zheng (US)
OC-WE-007
8:00 AM - 8:15 AM
ANTI-THROMBOTIC EFFECTS OF AN ANTI-VON WILLEBRAND FACTOR A1 DOMAIN APTAMER IN BLOOD FROM PATIENTS UNDER ASPIRIN AND CLOPIDOGREL THERAPY
D. Arzamendi* (CA), F. Dandachli, G. Ducroq, J. F. Théorêt, W. Mourad, J. Gilbert, R. Schaub, J. F. Tanguay, Y. Merhi
8:00 AM - 8:15 AM
ANTI-THROMBOTIC EFFECTS OF AN ANTI-VON WILLEBRAND FACTOR A1 DOMAIN APTAMER IN BLOOD FROM PATIENTS UNDER ASPIRIN AND CLOPIDOGREL THERAPY
D. Arzamendi* (CA), F. Dandachli, G. Ducroq, J. F. Théorêt, W. Mourad, J. Gilbert, R. Schaub, J. F. Tanguay, Y. Merhi
OC-WE-008
8:15 AM - 8:30 AM
IDENTIFICATION OF 41 JAPANESE PATIENTS WITH UPSHAW-SHULMAN SYNDROME, WITH SPECIAL REFERENCE TO ITS GENOTYPEPHENOTYPE ANALYSIS
Y. Fujimura* (JP), K. Kokame, M. Matsumoto, A. Isonishi, S. Kato, H. Hiura, T. Miyata
8:15 AM - 8:30 AM
IDENTIFICATION OF 41 JAPANESE PATIENTS WITH UPSHAW-SHULMAN SYNDROME, WITH SPECIAL REFERENCE TO ITS GENOTYPEPHENOTYPE ANALYSIS
Y. Fujimura* (JP), K. Kokame, M. Matsumoto, A. Isonishi, S. Kato, H. Hiura, T. Miyata
OC-WE-009
8:30 AM - 8:45 AM
ADAMTS13 ACTIVITY, RACE, AND AGE AS PREDICTORS OF EXACERBATION IN PATIENTS WITH IDIOPATHIC TTP
S. R. Cataland* (US), S. Yang, L. Witkoff, E. H. Kraut, S. Lin, J. N. George, H. M. Wu
8:30 AM - 8:45 AM
ADAMTS13 ACTIVITY, RACE, AND AGE AS PREDICTORS OF EXACERBATION IN PATIENTS WITH IDIOPATHIC TTP
S. R. Cataland* (US), S. Yang, L. Witkoff, E. H. Kraut, S. Lin, J. N. George, H. M. Wu
OC-WE-010
8:45 AM - 9:00 AM
RESPONSIVENESS OF VON WILLEBRAND FACTOR (VWF) TO SHEAR STRESS MAY AFFECT THE THROMBOTIC PHENOTYPE OF ADAMTS13 DEFICIENCY
W. Zhou* (US), H. Tsai
8:45 AM - 9:00 AM
RESPONSIVENESS OF VON WILLEBRAND FACTOR (VWF) TO SHEAR STRESS MAY AFFECT THE THROMBOTIC PHENOTYPE OF ADAMTS13 DEFICIENCY
W. Zhou* (US), H. Tsai
OC-WE-011
9:00 AM - 9:15 AM
THE ANTI VON WILLEBRAND FACTOR APTAMER ARC1779 INCREASES PLATELET COUNTS IN A PATIENT WITH FAMILIAL THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)
C. Firbas, B. Jilma* (AT), J. C. Gilbert, S. Schranz, P. Knöbl
9:00 AM - 9:15 AM
THE ANTI VON WILLEBRAND FACTOR APTAMER ARC1779 INCREASES PLATELET COUNTS IN A PATIENT WITH FAMILIAL THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)
C. Firbas, B. Jilma* (AT), J. C. Gilbert, S. Schranz, P. Knöbl
OC-WE-012
9:15 AM - 9:30 AM
ECULIZUMAB IN CONGENITAL RELAPSING AHUS/TTP R. A. Gruppo* (US), V. Fremeaux-Bacchi, R. P. Rother
Chairpersons: Pieter Kamphuisen (NL) and Suzanne Cannegieter (NL)
9:15 AM - 9:30 AM
ECULIZUMAB IN CONGENITAL RELAPSING AHUS/TTP R. A. Gruppo* (US), V. Fremeaux-Bacchi, R. P. Rother
Chairpersons: Pieter Kamphuisen (NL) and Suzanne Cannegieter (NL)
OC-WE-013
8:00 AM - 8:15 AM
INCREASED LEVELS OF THYROXIN INCREASE THE RISK OF VENOUS THROMBOSIS
S. C. Cannegieter* (NL), J. Debeij, O. M. Dekkers, S. C. Christiansen, I. Naess, B. O. Asvold, J. Hammerstrom, F. R. Rosendaal
8:00 AM - 8:15 AM
INCREASED LEVELS OF THYROXIN INCREASE THE RISK OF VENOUS THROMBOSIS
S. C. Cannegieter* (NL), J. Debeij, O. M. Dekkers, S. C. Christiansen, I. Naess, B. O. Asvold, J. Hammerstrom, F. R. Rosendaal
OC-WE-014
8:15 AM - 8:30 AM
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS INCREASE THE RISK OF PULMONARY EMBOLISM
S. Rafi* (NL), M. di Nisio, E. Porreca, A. de Boer, P. C. Souverein, H. R. Buller, P. W. Kamphuisen
8:15 AM - 8:30 AM
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS INCREASE THE RISK OF PULMONARY EMBOLISM
S. Rafi* (NL), M. di Nisio, E. Porreca, A. de Boer, P. C. Souverein, H. R. Buller, P. W. Kamphuisen
OC-WE-015
8:30 AM - 8:45 AM
COAGULATION FACTORS AND BLOOD GROUP AS RISK FACTORS FOR VENOUS THROMBOSIS OF THE UPPER EXTREMITY
L. E. Flinterman* (NL), A. van Hylckama Vlieg, F. R. Rosendaal, C. J. M. Doggen
8:30 AM - 8:45 AM
COAGULATION FACTORS AND BLOOD GROUP AS RISK FACTORS FOR VENOUS THROMBOSIS OF THE UPPER EXTREMITY
L. E. Flinterman* (NL), A. van Hylckama Vlieg, F. R. Rosendaal, C. J. M. Doggen
OC-WE-016
8:45 AM - 9:00 AM
PLASMA LEVELS OF FIBRINOLYTIC PROTEINS AND THE RISK OF VENOUS THROMBOSIS
M. E. Meltzer* (NL), T. Lisman, J. C. M. Meijers, P. G. de Groot, C. J. M. Doggen, F. R. Rosendaal
8:45 AM - 9:00 AM
PLASMA LEVELS OF FIBRINOLYTIC PROTEINS AND THE RISK OF VENOUS THROMBOSIS
M. E. Meltzer* (NL), T. Lisman, J. C. M. Meijers, P. G. de Groot, C. J. M. Doggen, F. R. Rosendaal
OC-WE-017
9:00 AM - 9:15 AM
ASSOCIATION OF INFLUENZA VACCINATION WITH REDUCED RISK OF VENOUS THROMBOEMBOLISM
J. Emmerich* (FR), T. Zhu, L. Carcaillon, I. Martinez, J. Cambou, X. Kyndt, K. Guillot, M. Vergnes, P. Scarabin
9:00 AM - 9:15 AM
ASSOCIATION OF INFLUENZA VACCINATION WITH REDUCED RISK OF VENOUS THROMBOEMBOLISM
J. Emmerich* (FR), T. Zhu, L. Carcaillon, I. Martinez, J. Cambou, X. Kyndt, K. Guillot, M. Vergnes, P. Scarabin
OC-WE-018
9:15 AM - 9:30 AM
PREVALENCE OF VENOUS THROMBOEMBOLISM IN THE USA: NOW AND FUTURE
S. Deitelzweig* (US), J. Lin, B. H. Johnson, K. L. Schulman
Chairpersons: Chris Holmes (US) and Ajay Kakkar and (UK)
9:15 AM - 9:30 AM
PREVALENCE OF VENOUS THROMBOEMBOLISM IN THE USA: NOW AND FUTURE
S. Deitelzweig* (US), J. Lin, B. H. Johnson, K. L. Schulman
Chairpersons: Chris Holmes (US) and Ajay Kakkar and (UK)
OC-WE-019
8:00 AM - 8:15 AM
ENDOGENOUS ACTIVATED PROTEIN C PROTECTS AGAINST EXPERIMENTAL METASTASIS THROUGH SPHINGOSINE 1- PHOSPHATE RECEPTOR-1 MEDIATED VASCULAR ENDOTHELIAL BARRIER PROTECTION
G. L. van Sluis* (NL), T. M. H. Niers, W. Tigchelaar Gutter, C. T. Esmon, D. J. Richel, H. R. Buller, C. J. F. van Noorden, C. A. Spek
8:00 AM - 8:15 AM
ENDOGENOUS ACTIVATED PROTEIN C PROTECTS AGAINST EXPERIMENTAL METASTASIS THROUGH SPHINGOSINE 1- PHOSPHATE RECEPTOR-1 MEDIATED VASCULAR ENDOTHELIAL BARRIER PROTECTION
G. L. van Sluis* (NL), T. M. H. Niers, W. Tigchelaar Gutter, C. T. Esmon, D. J. Richel, H. R. Buller, C. J. F. van Noorden, C. A. Spek
OC-WE-020
8:15 AM - 8:30 AM
PLATELET GLYCOPROTEIN VI FACILITATES MURINE EXPERIMENTAL METASTASIS
S. Jain* (US), S. Russell, J. Ware
8:15 AM - 8:30 AM
PLATELET GLYCOPROTEIN VI FACILITATES MURINE EXPERIMENTAL METASTASIS
S. Jain* (US), S. Russell, J. Ware
OC-WE-021
8:30 AM - 8:45 AM
MDA-9/SYNTENIN PROMOTES ACTIVE TISSUE-FACTOR/FVIIa COMPLEX ASSEMBLY AND MEDIATES TUMOR CELL MIGRATION AND INVASION
C. Prévost, H. Aissaoui, J. C. Bordet, J. L. Plantier, Y. Dargaud, C. Negrier, P. B. Fisher, H. Boukerche, H. Boukerche* (FR)
8:30 AM - 8:45 AM
MDA-9/SYNTENIN PROMOTES ACTIVE TISSUE-FACTOR/FVIIa COMPLEX ASSEMBLY AND MEDIATES TUMOR CELL MIGRATION AND INVASION
C. Prévost, H. Aissaoui, J. C. Bordet, J. L. Plantier, Y. Dargaud, C. Negrier, P. B. Fisher, H. Boukerche, H. Boukerche* (FR)
OC-WE-022
8:45 AM - 9:00 AM
A TISSUE PLASMINOGEN ACTIVATOR DEFICIENCY ENHANCES ADENOMA GROWTH AND ANGIOGENESIS IN A MODEL OF FAMILIAL ADENOMATOUS POLYPOSIS
V. A. Ploplis* (US), H. Tipton, S. Chapman, M. J. Sandoval-Cooper, R. D. Balsara, A. Carmony, H. Menchen, F. J. Castellino
8:45 AM - 9:00 AM
A TISSUE PLASMINOGEN ACTIVATOR DEFICIENCY ENHANCES ADENOMA GROWTH AND ANGIOGENESIS IN A MODEL OF FAMILIAL ADENOMATOUS POLYPOSIS
V. A. Ploplis* (US), H. Tipton, S. Chapman, M. J. Sandoval-Cooper, R. D. Balsara, A. Carmony, H. Menchen, F. J. Castellino
OC-WE-023
9:00 AM - 9:15 AM
COAGULATION ACTIVATION AND INFLAMMATION IN A PROMYELOCYTIC LEUKEMIC MICE MODEL
M. C. Pintao* (BR), B. A. A. Santana-Lemos, F. G. Mangolini, L. L. Figueiredo-Pontes, F. P. Saggioro, C. L. A. Silva, P. S. Scheucher, G. A. S. Santos, M. S. Baggio, A. B. Garcia, A. A. Garcia, E. M. Rego
9:00 AM - 9:15 AM
COAGULATION ACTIVATION AND INFLAMMATION IN A PROMYELOCYTIC LEUKEMIC MICE MODEL
M. C. Pintao* (BR), B. A. A. Santana-Lemos, F. G. Mangolini, L. L. Figueiredo-Pontes, F. P. Saggioro, C. L. A. Silva, P. S. Scheucher, G. A. S. Santos, M. S. Baggio, A. B. Garcia, A. A. Garcia, E. M. Rego
OC-WE-024 9:15 AM - 9:30 AM
DOWN REGULATION OF THE EXPRESSION OF KEY GENES FOLLOWING TREATMENT OF BREAST CANCER CELLS WITH HEPARIN
M. F. Scully, G. Dawson, C. Goodwin, T. Razzaq, A. K. Kakkar* (UK)
Chairpersons: Wolfram Ruf (US) and Vivien Chen (US)
DOWN REGULATION OF THE EXPRESSION OF KEY GENES FOLLOWING TREATMENT OF BREAST CANCER CELLS WITH HEPARIN
M. F. Scully, G. Dawson, C. Goodwin, T. Razzaq, A. K. Kakkar* (UK)
Chairpersons: Wolfram Ruf (US) and Vivien Chen (US)
OC-WE-025
8:00 AM - 8:15 AM
TISSUE FACTOR (TF) LOCALIZATION AND ACTIVITIES IN BLOOD CELLS: MONOCYTES THE ONLY CELL POSSESSING TF ACTIVITY AND ANTIGEN AND MICROPARTICLES ARE FREE OF TF
B. Osterud* (NO), J. Olsen
8:00 AM - 8:15 AM
TISSUE FACTOR (TF) LOCALIZATION AND ACTIVITIES IN BLOOD CELLS: MONOCYTES THE ONLY CELL POSSESSING TF ACTIVITY AND ANTIGEN AND MICROPARTICLES ARE FREE OF TF
B. Osterud* (NO), J. Olsen
OC-WE-026
8:15 AM - 8:30 AM
ACTIVATION OF TISSUE FACTOR-DEPENDENT CLOTTING PATHWAY IN HUMAN PLATELETS IS AGONIST-SPECIFIC, USES SRC-LYN SIGNALING PATHWAY, IS NOT INHIBITED BY TFPI AND IS NOT INDUCED BY PKC-SIGNALING AGONISTS
D. Mezzano* (CL), G. Valenzuela, V. Matus, J. Pereira, O. Panes
8:15 AM - 8:30 AM
ACTIVATION OF TISSUE FACTOR-DEPENDENT CLOTTING PATHWAY IN HUMAN PLATELETS IS AGONIST-SPECIFIC, USES SRC-LYN SIGNALING PATHWAY, IS NOT INHIBITED BY TFPI AND IS NOT INDUCED BY PKC-SIGNALING AGONISTS
D. Mezzano* (CL), G. Valenzuela, V. Matus, J. Pereira, O. Panes
OC-WE-027
8:30 AM - 8:45 AM
HIGH MOBILITY GROUP BOX 1 PROTEIN INDUCES TISSUE FACTOR EXPRESSION IN VASCULAR ENDOTHELIAL CELLS VIA ACTIVATION OF NFB AND EGR-1
F. Chen* (CN), B. Lv, H. Wang, Y. Tang, X. Xiao
8:30 AM - 8:45 AM
HIGH MOBILITY GROUP BOX 1 PROTEIN INDUCES TISSUE FACTOR EXPRESSION IN VASCULAR ENDOTHELIAL CELLS VIA ACTIVATION OF NFB AND EGR-1
F. Chen* (CN), B. Lv, H. Wang, Y. Tang, X. Xiao
OC-WE-028
8:45 AM - 9:00 AM
DYNAMIN2- MEDIATED CAVEOLAE INTERNALIZATION CONTROLS THE CELL SURFACE ACTIVITY OF TISSUE FACTOR PATHWAY INHIBITOR IN ENDOTHELIAL CELLS
C. Lupu* (US), N. I. Popescu, R. Silasi-Mansat, H. Zhu, F. Lupu
8:45 AM - 9:00 AM
DYNAMIN2- MEDIATED CAVEOLAE INTERNALIZATION CONTROLS THE CELL SURFACE ACTIVITY OF TISSUE FACTOR PATHWAY INHIBITOR IN ENDOTHELIAL CELLS
C. Lupu* (US), N. I. Popescu, R. Silasi-Mansat, H. Zhu, F. Lupu
OC-WE-029
9:00 AM - 9:15 AM
ROLE OF THE RENIN ANGIOTENSIN SYSTEM IN THE MODULATION OF TISSUE FACTOR EXPRESSION BY TNF-ALPHA-STIMULATED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
A. Del Fiorentino, S. Cianchetti, C. Armani, R. Pedrinelli, A. Celi* (IT)
9:00 AM - 9:15 AM
ROLE OF THE RENIN ANGIOTENSIN SYSTEM IN THE MODULATION OF TISSUE FACTOR EXPRESSION BY TNF-ALPHA-STIMULATED HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
A. Del Fiorentino, S. Cianchetti, C. Armani, R. Pedrinelli, A. Celi* (IT)
OC-WE-030
9:15 AM - 9:30 AM
ASSEMBLY OF THE PROTHROMBINASE COMPLEX IN THE PRESENCE OF TSP1 ON THE FIBROBLAST SURFACE INDUCES UPREGULATION OF CTGF BY TWO SEPARATE SIGNALING PATHWAYS
M. C. Rico* (US), J. J. Rough, J. M. Manns, S. P. Kunapuli, R. A. Dela Cadena
Chairpersons: Nancy Jenny (US) and Francesco Sofi (IT)
9:15 AM - 9:30 AM
ASSEMBLY OF THE PROTHROMBINASE COMPLEX IN THE PRESENCE OF TSP1 ON THE FIBROBLAST SURFACE INDUCES UPREGULATION OF CTGF BY TWO SEPARATE SIGNALING PATHWAYS
M. C. Rico* (US), J. J. Rough, J. M. Manns, S. P. Kunapuli, R. A. Dela Cadena
Chairpersons: Nancy Jenny (US) and Francesco Sofi (IT)
OC-WE-031
8:00 AM - 8:15 AM
HOMOCYSTEINE, B-GROUP VITAMINS (VITAMIN B6 AND FOLIC ACID) AND RHEOLOGICAL PARAMETERS AS INDEPENDENT RISK FACTORS FOR RETINAL VEIN OCCLUSION
F. Sofi* (IT), R. Marcucci, L. Mannini, B. Giambene, A. Sodi, U. Menchini, R. Abbate, G. Gensini, D. Prisco
8:00 AM - 8:15 AM
HOMOCYSTEINE, B-GROUP VITAMINS (VITAMIN B6 AND FOLIC ACID) AND RHEOLOGICAL PARAMETERS AS INDEPENDENT RISK FACTORS FOR RETINAL VEIN OCCLUSION
F. Sofi* (IT), R. Marcucci, L. Mannini, B. Giambene, A. Sodi, U. Menchini, R. Abbate, G. Gensini, D. Prisco
OC-WE-032
8:15 AM - 8:30 AM
HIGH LIPOPROTEIN (A) LEVELS ARE ASSOCIATED WITH AN INCREASED RISK OF RETINAL VEIN OCCLUSION
F. Sofi* (IT), R. Marcucci, S. Fedi, B. Giambene, A. Sodi, U. Menchini, R. Abbate, G. Gensini, D. Prisco
8:15 AM - 8:30 AM
HIGH LIPOPROTEIN (A) LEVELS ARE ASSOCIATED WITH AN INCREASED RISK OF RETINAL VEIN OCCLUSION
F. Sofi* (IT), R. Marcucci, S. Fedi, B. Giambene, A. Sodi, U. Menchini, R. Abbate, G. Gensini, D. Prisco
OC-WE-033
8:30 AM - 8:45 AM
COAGULATION ACTIVATION MARKERS ARE ASSOCIATED WITH CARDIOVASCULAR EVENTS AND DEATH IN THE ELDERLY AT RISK: PROSPER STUDY COHORT
A. Rumley* (UK), G. Lowe, D. Stott, P. Welsh, M. Robertson, H. Murray, I. Ford, N. Sattar, R. Westendorp, T. de Craen
8:30 AM - 8:45 AM
COAGULATION ACTIVATION MARKERS ARE ASSOCIATED WITH CARDIOVASCULAR EVENTS AND DEATH IN THE ELDERLY AT RISK: PROSPER STUDY COHORT
A. Rumley* (UK), G. Lowe, D. Stott, P. Welsh, M. Robertson, H. Murray, I. Ford, N. Sattar, R. Westendorp, T. de Craen
OC-WE-034
8:45 AM - 9:00 AM
FACTOR XIII ACTIVATION PEPTIDE AND SUBUNIT ANTIGEN LEVELS IN PATIENTS WITH ACUTE ISCHAEMIC STROKE
E. Ortner, H. P. Kohler, M. Mono, A. Galimanis, N. Meier, O. Findling, M. Arnold, H. P. Mattle, V. Schroeder* (CH)
8:45 AM - 9:00 AM
FACTOR XIII ACTIVATION PEPTIDE AND SUBUNIT ANTIGEN LEVELS IN PATIENTS WITH ACUTE ISCHAEMIC STROKE
E. Ortner, H. P. Kohler, M. Mono, A. Galimanis, N. Meier, O. Findling, M. Arnold, H. P. Mattle, V. Schroeder* (CH)
OC-WE-035
9:00 AM - 9:15 AM
NON-SELECTIVE BETA-BLOCKERS DECREASE THROMBOTIC EVENTS IN PATIENTS WITH HEART FAILURE
O. R. de Peuter* (NL), P. C. Souverein, O. H. Klungel, A. de Boer, H. R. Büller, P. W. Kamphuisen
9:00 AM - 9:15 AM
NON-SELECTIVE BETA-BLOCKERS DECREASE THROMBOTIC EVENTS IN PATIENTS WITH HEART FAILURE
O. R. de Peuter* (NL), P. C. Souverein, O. H. Klungel, A. de Boer, H. R. Büller, P. W. Kamphuisen
OC-WE-036
9:15 AM - 9:30 AM
ACTIVATION OF THE INTRINSIC COAGULATION PROTEINS AND THE RISK OF ARTERIAL THROMBOSIS IN YOUNG WOMEN
B. Siegerink* (NL), J. W. P. Govers-Riemslag, F. R. Rosendaal, H. ten Cate, A. Algra
Chairpersons: David Motto (US) and Roger Lijnen (BE)
9:15 AM - 9:30 AM
ACTIVATION OF THE INTRINSIC COAGULATION PROTEINS AND THE RISK OF ARTERIAL THROMBOSIS IN YOUNG WOMEN
B. Siegerink* (NL), J. W. P. Govers-Riemslag, F. R. Rosendaal, H. ten Cate, A. Algra
Chairpersons: David Motto (US) and Roger Lijnen (BE)
OC-WE-037
8:00 AM - 8:15 AM
GENERATION AND PHENOTYPIC ANALYSIS OF PROTEIN S-DEFICIENT MICE
F. Saller* (CH), A. C. Brisset, M. Azevedo, R. Chrast, M. Schapira, A. Angelillo-Scherrer
8:00 AM - 8:15 AM
GENERATION AND PHENOTYPIC ANALYSIS OF PROTEIN S-DEFICIENT MICE
F. Saller* (CH), A. C. Brisset, M. Azevedo, R. Chrast, M. Schapira, A. Angelillo-Scherrer
OC-WE-038
8:15 AM - 8:30 AM
DIRECT EFFECTS OF PROTEIN S IN AMELIORATING ACUTE LUNG INJURY
T. Takagi* (JP), E. C. Gabazza, J. Morser, S. Aoki, H. Fujimoto, C. N. D’Alessandro-Gabazza, M. Toda, A. Fujiwara, Y. Takei, O. Taguchi
8:15 AM - 8:30 AM
DIRECT EFFECTS OF PROTEIN S IN AMELIORATING ACUTE LUNG INJURY
T. Takagi* (JP), E. C. Gabazza, J. Morser, S. Aoki, H. Fujimoto, C. N. D’Alessandro-Gabazza, M. Toda, A. Fujiwara, Y. Takei, O. Taguchi
OC-WE-039
8:30 AM - 8:45 AM
A SENSITIZED SUPPRESSOR SCREEN TO IDENTIFY MODIFIER GENES FOR FACTOR V LEIDEN-DEPENDENT THROMBOSIS IN THE MOUSE
R. J. Westrick* (US), S. L. Manning, G. Zhu, D. R. Siemieniak, D. Ginsburg
8:30 AM - 8:45 AM
A SENSITIZED SUPPRESSOR SCREEN TO IDENTIFY MODIFIER GENES FOR FACTOR V LEIDEN-DEPENDENT THROMBOSIS IN THE MOUSE
R. J. Westrick* (US), S. L. Manning, G. Zhu, D. R. Siemieniak, D. Ginsburg
OC-WE-040
8:45 AM - 9:00 AM
DEFICIENCY OF VON WILLEBRAND FACTOR PROTECTS MICE FROM ISCHEMIC STROKE
S. F. de Meyer* (BE), C. Kleinschnitz, T. Schwarz, M. Austinat, K. Vanhoorelbeke, B. Nieswandt, H. Deckmyn, G. Stoll
8:45 AM - 9:00 AM
DEFICIENCY OF VON WILLEBRAND FACTOR PROTECTS MICE FROM ISCHEMIC STROKE
S. F. de Meyer* (BE), C. Kleinschnitz, T. Schwarz, M. Austinat, K. Vanhoorelbeke, B. Nieswandt, H. Deckmyn, G. Stoll
OC-WE-041
9:00 AM - 9:15 AM
SCANNING ELECTRON MICROSCOPY STUDY OF ENDOTHELIAL INJURY AND THROMBUS FORMATION IN WT AND VWF-DEFICIENT MICE
J. D. Barr* (US), D. G. Motto
9:00 AM - 9:15 AM
SCANNING ELECTRON MICROSCOPY STUDY OF ENDOTHELIAL INJURY AND THROMBUS FORMATION IN WT AND VWF-DEFICIENT MICE
J. D. Barr* (US), D. G. Motto
OC-WE-042
9:15 AM - 9:30 AM
A MURINE MODEL TO TEST ANTITHROMBOTIC DRUGS TARGETING HUMAN VON WILLEBRAND FACTOR
R. Pendu* (FR), I. Marx, P. J. Lenting, O. D. Christophe, C. V. Denis
Chairpersons: Satya Kunapuli (US) and Yotis Senis (UK)
9:15 AM - 9:30 AM
A MURINE MODEL TO TEST ANTITHROMBOTIC DRUGS TARGETING HUMAN VON WILLEBRAND FACTOR
R. Pendu* (FR), I. Marx, P. J. Lenting, O. D. Christophe, C. V. Denis
Chairpersons: Satya Kunapuli (US) and Yotis Senis (UK)
OC-WE-043
8:00 AM - 8:15 AM
THE MITOGEN-ACTIVATED PROTEIN KINASE JNK1 IS INVOLVED IN PLATELET FUNCTION AND THROMBUS GROWTH
F. Adam* (FR), A. Kauskot, E. Sulpice, M. F. Hoylaerts, R. J. Davis, J. Rosa, M. Bryckaert
8:00 AM - 8:15 AM
THE MITOGEN-ACTIVATED PROTEIN KINASE JNK1 IS INVOLVED IN PLATELET FUNCTION AND THROMBUS GROWTH
F. Adam* (FR), A. Kauskot, E. Sulpice, M. F. Hoylaerts, R. J. Davis, J. Rosa, M. Bryckaert
OC-WE-044
8:15 AM - 8:30 AM
THE CONTRIBUTION OF THROMBIN-INDUCED PLATELET ACTIVATION TO THROMBOSIS IS DEPENDENT ON BLOOD SHEAR RATE
J. R. Hamilton* (AU), H. Lee, S. A. Sturgeon, A. Ono, H. H. Salem, S. P. Jackson
8:15 AM - 8:30 AM
THE CONTRIBUTION OF THROMBIN-INDUCED PLATELET ACTIVATION TO THROMBOSIS IS DEPENDENT ON BLOOD SHEAR RATE
J. R. Hamilton* (AU), H. Lee, S. A. Sturgeon, A. Ono, H. H. Salem, S. P. Jackson
OC-WE-045
8:30 AM - 8:45 AM
A ROLE FOR MICRO-RNA IN THE REGULATION OF HUMAN VAMP8 EXPRESSION AND PLATELET REACTIVITY
A. Kondkar* (US), S. Nagalla, M. Bray, C. Shaw, S. Leal, Y. Jin, S. Whiteheart, P. F. Bray
8:30 AM - 8:45 AM
A ROLE FOR MICRO-RNA IN THE REGULATION OF HUMAN VAMP8 EXPRESSION AND PLATELET REACTIVITY
A. Kondkar* (US), S. Nagalla, M. Bray, C. Shaw, S. Leal, Y. Jin, S. Whiteheart, P. F. Bray
OC-WE-046
8:45 AM - 9:00 AM
THE HDL RECEPTOR SR-BI MODULATES PLATELET FUNCTION AND SUSCEPTIBILITY TO THROMBOSIS IN VIVO
S. J. A. Korporaal* (NL), I. Meurs, M. Vergeer, A. Hauer, R. B. Hildebrand, D. Praticò, J. N. Akkerman, T. J. C. van Berkel, J. Kuiper, J. A. Kuivenhoven, M. van Eck
8:45 AM - 9:00 AM
THE HDL RECEPTOR SR-BI MODULATES PLATELET FUNCTION AND SUSCEPTIBILITY TO THROMBOSIS IN VIVO
S. J. A. Korporaal* (NL), I. Meurs, M. Vergeer, A. Hauer, R. B. Hildebrand, D. Praticò, J. N. Akkerman, T. J. C. van Berkel, J. Kuiper, J. A. Kuivenhoven, M. van Eck
OC-WE-047
9:00 AM - 9:15 AM
STREPTOCOCCUS PNEUMONIAE TRIGGERS PLATELET ACTIVATION VIA TOLL LIKE RECEPTOR 2
A. Cunningham, C. Keane, D. Cox, A. Kadioglu, H. F. Jenkinson, S. W. Kerrigan* (IE)
9:00 AM - 9:15 AM
STREPTOCOCCUS PNEUMONIAE TRIGGERS PLATELET ACTIVATION VIA TOLL LIKE RECEPTOR 2
A. Cunningham, C. Keane, D. Cox, A. Kadioglu, H. F. Jenkinson, S. W. Kerrigan* (IE)
OC-WE-048
9:15 AM - 9:30 AM
THE ROLE OF FIBROUS COLLAGEN STRUCTURE IN DETERMINING ITS ABILITY TO BIND AND ACTIVATE PLATELETS
R. W. Farndale* (UK), A. B. Herr
Chairpersons: Scott Diamond (US) and Danila Leontyev (CA)
OC-WE-049
8:00 AM - 8:15 AM
A MICROFLUIDIC-BASED FOCAL INJURY MODEL PROVIDES A PLATFORM TO INVESTIGATE DRUG RESPONSE REGIMES ON THROMBUS FORMATION AND STABILITY
S. F. Maloney* (US), S. L. Diamond
OC-WE-050
8:15 AM - 8:30 AM
CONFORMATION CHANGE IN HUMAN BLOOD PROTEIN VON WILLEBRAND FACTOR INDUCED BY FLUID SHEAR
S. Neelamegham* (US), I. Singh, L. Porcar, E. Themistou
OC-WE-051
8:30 AM - 8:45 AM
MEMBRANE ELASTICITY AND CYTOSKELETAL STRUCTUREDETERMINE PLATELET TETHER AND MICROPARTICLE FORMATION UNDER SHEAR STRESS
A. J. Reininger* (DE), J. I. Angerer, M. Napoleone, A. Kern, M. F. Schneider
9:15 AM - 9:30 AM
THE ROLE OF FIBROUS COLLAGEN STRUCTURE IN DETERMINING ITS ABILITY TO BIND AND ACTIVATE PLATELETS
R. W. Farndale* (UK), A. B. Herr
Chairpersons: Scott Diamond (US) and Danila Leontyev (CA) OC-WE-049
8:00 AM - 8:15 AM
A MICROFLUIDIC-BASED FOCAL INJURY MODEL PROVIDES A PLATFORM TO INVESTIGATE DRUG RESPONSE REGIMES ON THROMBUS FORMATION AND STABILITY
S. F. Maloney* (US), S. L. Diamond
OC-WE-050
8:15 AM - 8:30 AM
CONFORMATION CHANGE IN HUMAN BLOOD PROTEIN VON WILLEBRAND FACTOR INDUCED BY FLUID SHEAR
S. Neelamegham* (US), I. Singh, L. Porcar, E. Themistou
OC-WE-051
8:30 AM - 8:45 AM
MEMBRANE ELASTICITY AND CYTOSKELETAL STRUCTUREDETERMINE PLATELET TETHER AND MICROPARTICLE FORMATION UNDER SHEAR STRESS
A. J. Reininger* (DE), J. I. Angerer, M. Napoleone, A. Kern, M. F. Schneider
OC-WE-052
8:45 AM - 9:00 AM
IMMUNOSELECTION OF ZEBRAFISH YOUNG AND MATURE THROMBOCYTES AND IDENTIFICATION OF NOVEL G-PROTEIN COUPLED RECEPTORS (GPCRS)
V. Kulkarni* (US), S. Kim, L. Zafreen, P. Jagadeeswaran
8:45 AM - 9:00 AM
IMMUNOSELECTION OF ZEBRAFISH YOUNG AND MATURE THROMBOCYTES AND IDENTIFICATION OF NOVEL G-PROTEIN COUPLED RECEPTORS (GPCRS)
V. Kulkarni* (US), S. Kim, L. Zafreen, P. Jagadeeswaran
OC-WE-053
9:00 AM - 9:15 AM
A MICROFLUIDIC METHOD FOR CONTROLLING THE FLUX OF PLATELET AGONISTS INTO FLOWING BLOOD
K. B. Neeves* (US), S. L. Diamond
9:00 AM - 9:15 AM
A MICROFLUIDIC METHOD FOR CONTROLLING THE FLUX OF PLATELET AGONISTS INTO FLOWING BLOOD
K. B. Neeves* (US), S. L. Diamond
OC-WE-054
9:15 AM - 9:30 AM
REALTIME IMAGING ANALYSIS OF PHOSPHATIDYLSERINE EXPOSURE ON PLATELET THROMBUS USING INTRA-VITAL CONFOCAL MICROSCOPY
T. Urano* (JP), M. Rybaltowski, T. Hayashi, Y. Suzuki, H. Mogami
Chairpersons: Elena Santagostino (IT) and Olivier Christophe (FR)
9:15 AM - 9:30 AM
REALTIME IMAGING ANALYSIS OF PHOSPHATIDYLSERINE EXPOSURE ON PLATELET THROMBUS USING INTRA-VITAL CONFOCAL MICROSCOPY
T. Urano* (JP), M. Rybaltowski, T. Hayashi, Y. Suzuki, H. Mogami
Chairpersons: Elena Santagostino (IT) and Olivier Christophe (FR)
OC-WE-055
8:00 AM - 8:15 AM
SAFETY AND PHARMACOKINETICS OF A LONG-ACTING GLYCOPEGYLATED RFVIIa DERIVATIVE: A FIRST HUMAN DOSE TRIAL IN HEALTHY SUBJECTS
J. Møss* (DK), A. Rosholm, A. Laurén
8:00 AM - 8:15 AM
SAFETY AND PHARMACOKINETICS OF A LONG-ACTING GLYCOPEGYLATED RFVIIa DERIVATIVE: A FIRST HUMAN DOSE TRIAL IN HEALTHY SUBJECTS
J. Møss* (DK), A. Rosholm, A. Laurén
OC-WE-056
8:15 AM - 8:30 AM
PROLONGED EFFECT OF A LONG ACTING RFVIIa ON BLEEDING IN HAEMOPHILIC MICE COMPARED WITH RFVIIa
H. L. Holmberg* (DK), T. Elm, M. Tranholm, M. Ezban
8:15 AM - 8:30 AM
PROLONGED EFFECT OF A LONG ACTING RFVIIa ON BLEEDING IN HAEMOPHILIC MICE COMPARED WITH RFVIIa
H. L. Holmberg* (DK), T. Elm, M. Tranholm, M. Ezban
OC-WE-057
8:30 AM - 8:45 AM
ENHANCED AND PROLONGED EFFICACY OF A NOVEL RECOMBINANT FVIIa VARIANT (BAY86-6150) FOR ACUTE AND PROPHYLACTIC TREATMENTS IN HEMOPHILIA A (HEMA) MICE
T. Liu, X. Zhang, J. Pan, D. Sim, K. McLean, Z. Cui, J. M. Sommer, J. Haaning, X. Zhao, J. E. Murphy, G. F. Pierce, H. Jiang* (US)
8:30 AM - 8:45 AM
ENHANCED AND PROLONGED EFFICACY OF A NOVEL RECOMBINANT FVIIa VARIANT (BAY86-6150) FOR ACUTE AND PROPHYLACTIC TREATMENTS IN HEMOPHILIA A (HEMA) MICE
T. Liu, X. Zhang, J. Pan, D. Sim, K. McLean, Z. Cui, J. M. Sommer, J. Haaning, X. Zhao, J. E. Murphy, G. F. Pierce, H. Jiang* (US)
OC-WE-058
8:45 AM - 9:00 AM
HEMOSTATIC THERAPY IN ACQUIRED HAEMOPHILIA: DATA FROM THE EUROPEAN ACQUIRED HAEMOPHILIA (EACH2) REGISTRY
F. Baudo* (IT), P. Collins, A. Huth-Kühne, P. Knoebl, H. Lévesque, M. Pascual, L. Nemes, K. Peerlinck, L. Tengborn
8:45 AM - 9:00 AM
HEMOSTATIC THERAPY IN ACQUIRED HAEMOPHILIA: DATA FROM THE EUROPEAN ACQUIRED HAEMOPHILIA (EACH2) REGISTRY
F. Baudo* (IT), P. Collins, A. Huth-Kühne, P. Knoebl, H. Lévesque, M. Pascual, L. Nemes, K. Peerlinck, L. Tengborn
OC-WE-059
9:00 AM - 9:15 AM
BINDING TO ACTIVATED PLATELETS AND ENHANCED CLOTTING PROPERTIES OF THE RECOMBINANT FVIIa ANALOGUE BAY7
J. Pan* (US), J. Kim, D. Zhu, E. Blank, X. Zhang, T. Liu, J. Wu, D. Schneider, K. McLean, X. Zhao, D. Sim, H. Jiang, H. Apeler, J. E. Murphy, J. Haaning, G. F. Pierce, J. M. Sommer
9:00 AM - 9:15 AM
BINDING TO ACTIVATED PLATELETS AND ENHANCED CLOTTING PROPERTIES OF THE RECOMBINANT FVIIa ANALOGUE BAY7
J. Pan* (US), J. Kim, D. Zhu, E. Blank, X. Zhang, T. Liu, J. Wu, D. Schneider, K. McLean, X. Zhao, D. Sim, H. Jiang, H. Apeler, J. E. Murphy, J. Haaning, G. F. Pierce, J. M. Sommer
OC-WE-060
9:15 AM - 9:30 AM
THROMBIN GENERATION TEST OPTIMIZED TO MEASURE TREATMENT OF FACTOR VIII DEFICIENCY WITH RECOMBINANT FACTOR VIIa
P. L. A. Giesen* (NL), R. van Oerle, H. M. H. Spronk
Chairpersons: Steven Pipe (US) and Pauline van Helden (AT)
OC-WE-061
8:00 AM - 8:15 AM
WOUND HEALING IN HEMOPHILIA: PROGRESSIVE IMPROVEMENT WITH LONGER TREATMENT
D. M. Monroe* (US), M. Hoffman, J. Brock, M. Ezban, H. R. Roberts, U. Hedner
OC-WE-062
8:15 AM - 8:30 AM
TRANSGENIC MURINE MODEL FOR EVALUATING THE IMMUNOGENICITY OF BIOENGINEERED FACTOR VIII VARIANTS
H. Z. Miao, C. H. Miao, R. J. Kaufman, S. W. Pipe* (US)
OC-WE-063 8:30 AM - 8:45 AM
TOWARDS A NEW HEMOPHILIC MOUSE MODEL FOR THE DETECTION OF NEO-ANTIGEN FORMATION IN HUMAN FACTOR VIII
P. M. van Helden* (AT), S. Unterthurner, M. Schuster, G. Antoine, R. U. Ahmad, C. Hermann, E. M. Muchitsch, H. J. Ehrlich, H. Schwarz, B. M. Reipert
9:15 AM - 9:30 AM
THROMBIN GENERATION TEST OPTIMIZED TO MEASURE TREATMENT OF FACTOR VIII DEFICIENCY WITH RECOMBINANT FACTOR VIIa
P. L. A. Giesen* (NL), R. van Oerle, H. M. H. Spronk
Chairpersons: Steven Pipe (US) and Pauline van Helden (AT)
OC-WE-061
8:00 AM - 8:15 AM
WOUND HEALING IN HEMOPHILIA: PROGRESSIVE IMPROVEMENT WITH LONGER TREATMENT
D. M. Monroe* (US), M. Hoffman, J. Brock, M. Ezban, H. R. Roberts, U. Hedner
OC-WE-062
8:15 AM - 8:30 AM
TRANSGENIC MURINE MODEL FOR EVALUATING THE IMMUNOGENICITY OF BIOENGINEERED FACTOR VIII VARIANTS
H. Z. Miao, C. H. Miao, R. J. Kaufman, S. W. Pipe* (US)
OC-WE-063 8:30 AM - 8:45 AM
TOWARDS A NEW HEMOPHILIC MOUSE MODEL FOR THE DETECTION OF NEO-ANTIGEN FORMATION IN HUMAN FACTOR VIII
P. M. van Helden* (AT), S. Unterthurner, M. Schuster, G. Antoine, R. U. Ahmad, C. Hermann, E. M. Muchitsch, H. J. Ehrlich, H. Schwarz, B. M. Reipert
OC-WE-064
8:45 AM - 9:00 AM
TNF-ALPHA ANTAGONISTS AUGMENT FACTOR REPLACEMENT TO PREVENT ARTHROPATHY IN HEMOPHILIC MICE
J. Sun* (US), G. Hu, P. E. Monahan
OC-WE-065
9:00 AM - 9:15 AM
WEAK AGREEMENT BETWEEN COMPUTER SIMULATION AND IN VITRO BINDING ASSAYS FOR IDENTIFYING FACTOR VIII 15MER PEPTIDES THAT BIND TO THE MHC-CLASS II HAPLOTYPE HLA-DRB1*1501
K. N. Steinitz* (AT), P. M. van Helden, M. Wolfsegger, H. Ehrlich, H. P. Schwarz, B. M. Reipert
9:00 AM - 9:15 AM
WEAK AGREEMENT BETWEEN COMPUTER SIMULATION AND IN VITRO BINDING ASSAYS FOR IDENTIFYING FACTOR VIII 15MER PEPTIDES THAT BIND TO THE MHC-CLASS II HAPLOTYPE HLA-DRB1*1501
K. N. Steinitz* (AT), P. M. van Helden, M. Wolfsegger, H. Ehrlich, H. P. Schwarz, B. M. Reipert
OC-WE-066
9:15 AM - 9:30 AM
ACCUMULATION OF THERAPEUTIC FACTOR VIII IN THE MARGINAL ZONE OF THE SPLEEN OF FACTOR VIII-DEFICIENT MICE
S. Delignat* (FR), A. Navarrete, S. Dasgupta, Y. Repesse, S. André, Y. Meslier, M. Teyssandier, S. Kaveri, S. Lacroix-Desmazes
Chairpersons: Raffaele de Caterina (IT) and Bernard Binetruy (FR)
9:15 AM - 9:30 AM
ACCUMULATION OF THERAPEUTIC FACTOR VIII IN THE MARGINAL ZONE OF THE SPLEEN OF FACTOR VIII-DEFICIENT MICE
S. Delignat* (FR), A. Navarrete, S. Dasgupta, Y. Repesse, S. André, Y. Meslier, M. Teyssandier, S. Kaveri, S. Lacroix-Desmazes
Chairpersons: Raffaele de Caterina (IT) and Bernard Binetruy (FR)
OC-WE-067
8:00 AM - 8:15 AM
EXPRESSION OF TF AND PARS ON SMOOTH MUSCLE VASCULAR PROGENITORS DEFINES A PATTERN OF CD34+ MOBILISATION ASSOCIATED WITH INTIMAL HYPERPLASIA POST-TRANSPLANTATION
D. Chen* (UK), J. M. Abrahams, J. H. McVey, A. Dorling
8:00 AM - 8:15 AM
EXPRESSION OF TF AND PARS ON SMOOTH MUSCLE VASCULAR PROGENITORS DEFINES A PATTERN OF CD34+ MOBILISATION ASSOCIATED WITH INTIMAL HYPERPLASIA POST-TRANSPLANTATION
D. Chen* (UK), J. M. Abrahams, J. H. McVey, A. Dorling
OC-WE-068
8:15 AM - 8:30 AM
ALLOGENEIC MESENCHYMAL STEM CELLS CONFER VASCULAR PROTECTION AFTER BALLOON ANGIOPLASTY IN RABBIT CAROTIDS
P. Liu, L. Zhang* (CN), W. Liao, W. Du, D. Gu, M. Liu, J. Xu, S. Lu, W. Xing, S. Yang, B. Zhou, Z. Han
8:15 AM - 8:30 AM
ALLOGENEIC MESENCHYMAL STEM CELLS CONFER VASCULAR PROTECTION AFTER BALLOON ANGIOPLASTY IN RABBIT CAROTIDS
P. Liu, L. Zhang* (CN), W. Liao, W. Du, D. Gu, M. Liu, J. Xu, S. Lu, W. Xing, S. Yang, B. Zhou, Z. Han
OC-WE-069
8:30 AM - 8:45 AM
TUMOR BLOOD VESSEL FORMATION IS AFFECTED BY THE HUMAN CARCINOEMBRYONIC ANTIGEN (CEA)
K. Braemswig, M. Poettler, M. Cabaravbic, B. Binder, C. C. Zielinski, G. W. Prager* (AT)
8:30 AM - 8:45 AM
TUMOR BLOOD VESSEL FORMATION IS AFFECTED BY THE HUMAN CARCINOEMBRYONIC ANTIGEN (CEA)
K. Braemswig, M. Poettler, M. Cabaravbic, B. Binder, C. C. Zielinski, G. W. Prager* (AT)
OC-WE-070
8:45 AM - 9:00 AM
PROTEASE NEXIN-1 IS ANTI-ANGIOGENIC IN VITRO INDEPENDENTLY OF ITS ANTI-PROTEASE ACTIVITY
V. Arocas* (FR), F. Azibani, S. Iatmanen, Y. Boulaftali, M. Bouton, M. Jandrot-Perrus
8:45 AM - 9:00 AM
PROTEASE NEXIN-1 IS ANTI-ANGIOGENIC IN VITRO INDEPENDENTLY OF ITS ANTI-PROTEASE ACTIVITY
V. Arocas* (FR), F. Azibani, S. Iatmanen, Y. Boulaftali, M. Bouton, M. Jandrot-Perrus
OC-WE-071
9:00 AM - 9:15 AM
THE OMEGA-3 FATTY ACID DOCOSAHEXAENOATE ATTENUATES INSULIN-INDUCED CD36 EXPRESSION IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS
R. Madonna, D. Schiavone, R. de Caterina* (IT)
9:00 AM - 9:15 AM
THE OMEGA-3 FATTY ACID DOCOSAHEXAENOATE ATTENUATES INSULIN-INDUCED CD36 EXPRESSION IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS
R. Madonna, D. Schiavone, R. de Caterina* (IT)
OC-WE-072
9:15 AM - 9:30 AM
RESTRICTION OF GAMMA-GLUTAMYL CARBOXYLASE EXPRESSION TO THE LIVER LEADS TO MINERALIZATION IN BLOOD VESSEL WALL AND HEART
M. M. Bronstein* (US), H. Sun, G. Merrill-Skoloff, M. Rishavy, B. Furie, K. Berkner, B. C. Furie, D. Ginsburg
Chairpersons: Darrel Stafford (US) and Weikai Li (US)
9:15 AM - 9:30 AM
RESTRICTION OF GAMMA-GLUTAMYL CARBOXYLASE EXPRESSION TO THE LIVER LEADS TO MINERALIZATION IN BLOOD VESSEL WALL AND HEART
M. M. Bronstein* (US), H. Sun, G. Merrill-Skoloff, M. Rishavy, B. Furie, K. Berkner, B. C. Furie, D. Ginsburg
Chairpersons: Darrel Stafford (US) and Weikai Li (US)
OC-WE-073
8:00 AM - 8:15 AM
GAMMA-GLUTAMYL CARBOXYLASE IS A CARGO RECEPTOR FOR VITAMIN K-DEPENDENT PROTEINS
M. Souri* (JP), H. Iwata, W. Zhang, T. Nakagaki, A. Ichinose
8:00 AM - 8:15 AM
GAMMA-GLUTAMYL CARBOXYLASE IS A CARGO RECEPTOR FOR VITAMIN K-DEPENDENT PROTEINS
M. Souri* (JP), H. Iwata, W. Zhang, T. Nakagaki, A. Ichinose
OC-WE-074
8:15 AM - 8:30 AM
IN VITRO RECONSTITUTION OF VKOR-DEPENDENT DISULFIDE BRIDGE FORMATION
S. Schulman* (US), W. Li, R. Dutton, D. Boyd, J. Beckwith, T. Rapoport
8:15 AM - 8:30 AM
IN VITRO RECONSTITUTION OF VKOR-DEPENDENT DISULFIDE BRIDGE FORMATION
S. Schulman* (US), W. Li, R. Dutton, D. Boyd, J. Beckwith, T. Rapoport
OC-WE-075
8:30 AM - 8:45 AM
INVESTIGATION OF RESIDUES L394, Y395, AND W399 ROLES IN LINKAGE AMONG THE GAMMA-GLUTAMYL CARBOXYLASE (GGCX) SUBSTRATE BINDING SITES
V. P. Mutucumarana* (US), S. L. Higgins-Gruber, D. W. Stafford, D. L. Straight
8:30 AM - 8:45 AM
INVESTIGATION OF RESIDUES L394, Y395, AND W399 ROLES IN LINKAGE AMONG THE GAMMA-GLUTAMYL CARBOXYLASE (GGCX) SUBSTRATE BINDING SITES
V. P. Mutucumarana* (US), S. L. Higgins-Gruber, D. W. Stafford, D. L. Straight
OC-WE-076
8:45 AM - 9:00 AM
PHENOTYPE OF VKORC1 KNOCKOUT-MICE
G. Spohn* (DE), A. Kleinridders, M. Watzka, F. T. Wunderlich, F. Zaucke, K. Blumbach, C. Geisen, E. Seifried, C. Müller-Reible, M. Paulsson, J. C. Brüning, J. Oldenburg
8:45 AM - 9:00 AM
PHENOTYPE OF VKORC1 KNOCKOUT-MICE
G. Spohn* (DE), A. Kleinridders, M. Watzka, F. T. Wunderlich, F. Zaucke, K. Blumbach, C. Geisen, E. Seifried, C. Müller-Reible, M. Paulsson, J. C. Brüning, J. Oldenburg
OC-WE-077
9:00 AM - 9:15 AM
HEREDITARY WARFARIN RESISTANCE IN 16 PATIENTS DUE TO NINE NOVEL AND THREE KNOWN VKORC1 MUTATIONS
C. Geisen* (DE), M. Watzka, K. Sittinger, G. Spohn, D. M. Dimichele, H. Haubelt, M. Heistinger, J. G. Kadar, B. Kemkes-Matthes, R. Klamroth, P. Lages, E. Lindhoff-Last, B. Luxembourg, B. Mansouri Taleghani, H. Pollmann, M. Spannagl, S. Struve, R. Zimmermann, E. Seifried, J. Oldenburg
9:00 AM - 9:15 AM
HEREDITARY WARFARIN RESISTANCE IN 16 PATIENTS DUE TO NINE NOVEL AND THREE KNOWN VKORC1 MUTATIONS
C. Geisen* (DE), M. Watzka, K. Sittinger, G. Spohn, D. M. Dimichele, H. Haubelt, M. Heistinger, J. G. Kadar, B. Kemkes-Matthes, R. Klamroth, P. Lages, E. Lindhoff-Last, B. Luxembourg, B. Mansouri Taleghani, H. Pollmann, M. Spannagl, S. Struve, R. Zimmermann, E. Seifried, J. Oldenburg
OC-WE-078
9:15 AM - 9:30 AM
THE VITAMIN K-DEPENDENT CARBOXYLASE ACHIEVES EFFICIENT COUPLING OF VITAMIN K EPOXIDATION AND GLUTAMATE CARBOXYLATION USING A CONCERTED MECHANISM OF CARBANIONAND GAMMA-CARBOXYLATED GLUTAMATE FORMATION
M. A. Rishavy* (US), K. L. Berkner
Chairpersons: James Huntington (UK) and Neychelle Fernandes (US)
9:15 AM - 9:30 AM
THE VITAMIN K-DEPENDENT CARBOXYLASE ACHIEVES EFFICIENT COUPLING OF VITAMIN K EPOXIDATION AND GLUTAMATE CARBOXYLATION USING A CONCERTED MECHANISM OF CARBANIONAND GAMMA-CARBOXYLATED GLUTAMATE FORMATION
M. A. Rishavy* (US), K. L. Berkner
Chairpersons: James Huntington (UK) and Neychelle Fernandes (US)
OC-WE-079
8:00 AM - 8:15 AM
EXOSITE 2-DIRECTED LIGANDS MODULATE THE FUNCTION OF EXOSITE 1 ON THROMBIN
N. S. Petrera* (CA), A. R. Stafford, B. A. Leslie, J. C. Fredenburgh, J. I. Weitz
8:00 AM - 8:15 AM
EXOSITE 2-DIRECTED LIGANDS MODULATE THE FUNCTION OF EXOSITE 1 ON THROMBIN
N. S. Petrera* (CA), A. R. Stafford, B. A. Leslie, J. C. Fredenburgh, J. I. Weitz
OC-WE-080
8:15 AM - 8:30 AM
FLUORESCENCE RESONANCE ENERGY TRANSFER STUDIES OF PROTHROMBIN RECOGNITION BY PROTHROMBINASE E. Zekas* (US), S. Krishnaswamy
8:15 AM - 8:30 AM
FLUORESCENCE RESONANCE ENERGY TRANSFER STUDIES OF PROTHROMBIN RECOGNITION BY PROTHROMBINASE E. Zekas* (US), S. Krishnaswamy
OC-WE-081
8:30 AM - 8:45 AM
EFFECT OF GLYCOSYLATION ON THROMBIN STRUCTURE, STABILITY AND FUNCTION
R. Frasson* (IT), N. Pozzi, D. J. D. Johnson, J. A. Huntington, V. de Filippis
8:30 AM - 8:45 AM
EFFECT OF GLYCOSYLATION ON THROMBIN STRUCTURE, STABILITY AND FUNCTION
R. Frasson* (IT), N. Pozzi, D. J. D. Johnson, J. A. Huntington, V. de Filippis
OC-WE-082
8:45 AM - 9:00 AM
CONTRIBUTION OF PROTHROMBIN DOMAINS AND ACTIVE SITE LABELING TO CONFORMATIONAL ACTIVATION OF PROTHROMBIN BY VON WILLEBRAND FACTOR-BINDING PROTEIN
H. K. Kroh* (US), P. E. Bock
8:45 AM - 9:00 AM
CONTRIBUTION OF PROTHROMBIN DOMAINS AND ACTIVE SITE LABELING TO CONFORMATIONAL ACTIVATION OF PROTHROMBIN BY VON WILLEBRAND FACTOR-BINDING PROTEIN
H. K. Kroh* (US), P. E. Bock
OC-WE-083
9:00 AM - 9:15 AM
FRAGMENT-BASED ENZYME DESIGN OF COAGULATION FACTOR ACTIVITY
M. J. Page* (US), E. di Cera
9:00 AM - 9:15 AM
FRAGMENT-BASED ENZYME DESIGN OF COAGULATION FACTOR ACTIVITY
M. J. Page* (US), E. di Cera
OC-WE-084
9:15 AM - 9:30 AM
FACTOR VII-ACTIVATING PROTEASE (FSAP): DOES IT ACTIVATE FACTOR VII?
F. Stavenuiter* (NL), E. Sellink, H. J. M. Brinkman, A. B. Meijer, K. Mertens
Chairpersons: Christopher Jackson (AU) and David Smadja (FR)
9:15 AM - 9:30 AM
FACTOR VII-ACTIVATING PROTEASE (FSAP): DOES IT ACTIVATE FACTOR VII?
F. Stavenuiter* (NL), E. Sellink, H. J. M. Brinkman, A. B. Meijer, K. Mertens
Chairpersons: Christopher Jackson (AU) and David Smadja (FR)
OC-WE-085
8:00 AM - 8:15 AM
IMPACT OF SMOKING PROHIBITION IN BARS, RESTAURANTS AND DISCOTHEQUES ON EMPLOYEES’ ENDOTHELIAL FUNCTION: THE DILATER STUDY
A. Bura* (FR), S. Labro, N. Vaysse, D. Thomas, J. P. Cambou
8:00 AM - 8:15 AM
IMPACT OF SMOKING PROHIBITION IN BARS, RESTAURANTS AND DISCOTHEQUES ON EMPLOYEES’ ENDOTHELIAL FUNCTION: THE DILATER STUDY
A. Bura* (FR), S. Labro, N. Vaysse, D. Thomas, J. P. Cambou
OC-WE-086
8:15 AM - 8:30 AM
ACTIVATION OF THE HEMOSTATIC SYSTEM AND ENDOTHELIAL DYSFUNCTION IN CHRONIC COCAINE CONSUMERS: ASSOCIATION WITH BRAIN PERFUSION DEFECTS
J. Pereira* (CL), C. G. Sáez, P. Olivares, N. Moreno, M. J. Cabrera, O. Panes, P. Hidalgo, T. Massardo, J. Pallavicini, R. Jaimovich, J. C. Quintana, D. Mezzano
8:15 AM - 8:30 AM
ACTIVATION OF THE HEMOSTATIC SYSTEM AND ENDOTHELIAL DYSFUNCTION IN CHRONIC COCAINE CONSUMERS: ASSOCIATION WITH BRAIN PERFUSION DEFECTS
J. Pereira* (CL), C. G. Sáez, P. Olivares, N. Moreno, M. J. Cabrera, O. Panes, P. Hidalgo, T. Massardo, J. Pallavicini, R. Jaimovich, J. C. Quintana, D. Mezzano
OC-WE-087
8:30 AM - 8:45 AM
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION, AND NOT SHORT-TERM HIGHLY ACTIVE ANTIRETROVIRAL THERAPY, INDUCES ENDOTHELIAL DYSFUNCTION
S. Giannini* (IT), D. Francisci, F. Baldelli, M. Leone, B. Belfiori, G. Guglielmini, L. Malincarne, P. Gresele
8:30 AM - 8:45 AM
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION, AND NOT SHORT-TERM HIGHLY ACTIVE ANTIRETROVIRAL THERAPY, INDUCES ENDOTHELIAL DYSFUNCTION
S. Giannini* (IT), D. Francisci, F. Baldelli, M. Leone, B. Belfiori, G. Guglielmini, L. Malincarne, P. Gresele
OC-WE-088
8:45 AM - 9:00 AM
PLASMA MARKERS OF ENDOTHELIAL CELL ACTIVATION IN PATIENTS WITH SECONDARY PULMONARY HYPERTENSION RELATED TO CONNECTIVE TISSUE DISEASES: EFFECT OF BOSENTAN
E. Osto* (IT), F. Vianello, F. Tona, F. Cozzi, H. Marotta, G. Saggiorato, O. Iqbal, J. Fareed, G. Cella
8:45 AM - 9:00 AM
PLASMA MARKERS OF ENDOTHELIAL CELL ACTIVATION IN PATIENTS WITH SECONDARY PULMONARY HYPERTENSION RELATED TO CONNECTIVE TISSUE DISEASES: EFFECT OF BOSENTAN
E. Osto* (IT), F. Vianello, F. Tona, F. Cozzi, H. Marotta, G. Saggiorato, O. Iqbal, J. Fareed, G. Cella
OC-WE-089
9:00 AM - 9:15 AM
CIRCULATING ENDOTHELIAL CELLS ARE A NEW CANDIDATE BIOMARKER OF IRREVERSIBLE PULMONARY HYPERTENSION SECONDARY TO CONGENITAL HEART DISEASE
D. M. Smadja* (FR), P. Gaussem, L. Mauge, F. Dignat-George, D. Bonnet, M. Levy
9:00 AM - 9:15 AM
CIRCULATING ENDOTHELIAL CELLS ARE A NEW CANDIDATE BIOMARKER OF IRREVERSIBLE PULMONARY HYPERTENSION SECONDARY TO CONGENITAL HEART DISEASE
D. M. Smadja* (FR), P. Gaussem, L. Mauge, F. Dignat-George, D. Bonnet, M. Levy
OC-WE-090
9:15 AM - 9:30 AM
INCREASED LEVELS OF CIRCULATING ENDOTHELIAL CELLS IN PATIENTS WITH MAJOR DEPRESSION
C. G. Sáez* (CL), J. Pereira, L. Risco, P. Olivares, O. Panes, V. Araya, T. Galleguillos, T. Massardo, C. Liberman
Chairpersons: Paul Monagle (AU) and Sharene Bungay (CA)
9:15 AM - 9:30 AM
INCREASED LEVELS OF CIRCULATING ENDOTHELIAL CELLS IN PATIENTS WITH MAJOR DEPRESSION
C. G. Sáez* (CL), J. Pereira, L. Risco, P. Olivares, O. Panes, V. Araya, T. Galleguillos, T. Massardo, C. Liberman
Chairpersons: Paul Monagle (AU) and Sharene Bungay (CA)
OC-WE-091
8:00 AM - 8:15 AM
COAGULATION ABNORMALITIES IN LEGG-CALVÉ-PERTHES DISEASE
J. S. Koenderman* (NL), A. Vosmaer, R. Rodrigues Pereira, F. R. Rosendaal, S. C. Cannegieter
8:00 AM - 8:15 AM
COAGULATION ABNORMALITIES IN LEGG-CALVÉ-PERTHES DISEASE
J. S. Koenderman* (NL), A. Vosmaer, R. Rodrigues Pereira, F. R. Rosendaal, S. C. Cannegieter
OC-WE-092
8:15 AM - 8:30 AM
OVERWEIGHT YOUTH HAVE A DECREASED FIBRINOLYTIC CAPACITY: A POTENTIAL NOVEL RISK FACTOR FOR CARDIOVASCULAR DISEASE IN CHILDREN
G. Ball, K. Dietrich, S. Qayyum, L. G. Mitchell* (CA)
8:15 AM - 8:30 AM
OVERWEIGHT YOUTH HAVE A DECREASED FIBRINOLYTIC CAPACITY: A POTENTIAL NOVEL RISK FACTOR FOR CARDIOVASCULAR DISEASE IN CHILDREN
G. Ball, K. Dietrich, S. Qayyum, L. G. Mitchell* (CA)
OC-WE-093
8:30 AM - 8:45 AM
DOSING OF LMWH (ENOXAPARIN) THERAPY IN CHILDREN
V. Ignjatovic* (AU), S. Najid, F. Newall, R. Summerhayes, P. Monagle
8:30 AM - 8:45 AM
DOSING OF LMWH (ENOXAPARIN) THERAPY IN CHILDREN
V. Ignjatovic* (AU), S. Najid, F. Newall, R. Summerhayes, P. Monagle
OC-WE-094
8:45 AM - 9:00 AM
ENOXAPARIN POPULATION- PHARMACOKINETIC MODELLING [POP-PK] IN CHILDREN – PRELIMINARY RESULTS
L. Mitchell* (CA), A. Krumpel, J. Barett, U. Nowak-Gottl
8:45 AM - 9:00 AM
ENOXAPARIN POPULATION- PHARMACOKINETIC MODELLING [POP-PK] IN CHILDREN – PRELIMINARY RESULTS
L. Mitchell* (CA), A. Krumpel, J. Barett, U. Nowak-Gottl
OC-WE-095
9:00 AM - 9:15 AM
MODELLING THROMBIN GENERATION IN DEVELOPMENTAL HEMOSTASIS
S. D. Bungay* (CA), A. K. Chan
9:00 AM - 9:15 AM
MODELLING THROMBIN GENERATION IN DEVELOPMENTAL HEMOSTASIS
S. D. Bungay* (CA), A. K. Chan
OC-WE-096
9:15 AM - 9:30 AM
DECREASED GLOBAL FIBRINOLYTIC CAPACITY IN CHILDREN POST CARDIOPULMONARY BYPASS SURGERY FOR REPAIR OF CONGENITAL HEART DEFECTS: A PROSPECTIVE COHORT STUDY
L. G. Mitchell* (CA), K. Dietrich, I. Rebeyka, D. Ross, S. Qayyum
Chairpersons: Tetsuhito Kojima (JP) and Neil Zakai (US)
OC-WE-097
4:00 PM - 4:15 PM
FUNCTIONAL ANALYSIS OF COMMON HAEMOSTATIC GENE POLYMORPHISMS USING CALIBRATED AUTOMATED THROMBOGRAPHY
O. Segers* (NL), R. van Oerle, H. ten Cate, J. Rosing, E. Castoldi
OC-WE-098 4:15 PM - 4:30 PM
A GENOME WIDE LINKAGE SCAN FOR THROMBOSIS SUSCEPTIBILITY GENES IDENTIFIES A NOVEL PROTHROMBIN MUTATION
M. K. ten Kate* (US), C. He, I. M. van Schouwenburg, G. van der Steege, R. Mulder, C. Wijmenga, A. B. Mulder, H. C. Kluin-Nelemans, D. J. D. Johnson, J. A. Huntington, J. Ott, J. van der Meer
9:15 AM - 9:30 AM
DECREASED GLOBAL FIBRINOLYTIC CAPACITY IN CHILDREN POST CARDIOPULMONARY BYPASS SURGERY FOR REPAIR OF CONGENITAL HEART DEFECTS: A PROSPECTIVE COHORT STUDY
L. G. Mitchell* (CA), K. Dietrich, I. Rebeyka, D. Ross, S. Qayyum
Chairpersons: Tetsuhito Kojima (JP) and Neil Zakai (US) OC-WE-097
4:00 PM - 4:15 PM
FUNCTIONAL ANALYSIS OF COMMON HAEMOSTATIC GENE POLYMORPHISMS USING CALIBRATED AUTOMATED THROMBOGRAPHY
O. Segers* (NL), R. van Oerle, H. ten Cate, J. Rosing, E. Castoldi
OC-WE-098 4:15 PM - 4:30 PM
A GENOME WIDE LINKAGE SCAN FOR THROMBOSIS SUSCEPTIBILITY GENES IDENTIFIES A NOVEL PROTHROMBIN MUTATION
M. K. ten Kate* (US), C. He, I. M. van Schouwenburg, G. van der Steege, R. Mulder, C. Wijmenga, A. B. Mulder, H. C. Kluin-Nelemans, D. J. D. Johnson, J. A. Huntington, J. Ott, J. van der Meer
OC-WE-099
4:30 PM - 4:45 PM
IN PT G20210A CARRIERS THE GENETIC MUTATION AND THE HISTORY OF VENOUS THROMBOSIS CONTRIBUTE BOTH TO THROMBIN GENERATION INDEPENDENTLY OF FII PLASMA LEVELS
G. Lavigne Lissalde* (FR), C. Castelli, C. Sanchez, S. Alonso, E. Mazoyer, C. Bal Dit Sollier, L. Drouet, I. Juhan Vague, J. C. Gris, M. C. Alessi, P. E. Morange
4:30 PM - 4:45 PM
IN PT G20210A CARRIERS THE GENETIC MUTATION AND THE HISTORY OF VENOUS THROMBOSIS CONTRIBUTE BOTH TO THROMBIN GENERATION INDEPENDENTLY OF FII PLASMA LEVELS
G. Lavigne Lissalde* (FR), C. Castelli, C. Sanchez, S. Alonso, E. Mazoyer, C. Bal Dit Sollier, L. Drouet, I. Juhan Vague, J. C. Gris, M. C. Alessi, P. E. Morange
OC-WE-100
4:45 PM - 5:00 PM
RISK OF RECURRENT VENOUS THROMBOSIS IN HOMOZYGOUS CARRIERS, AND DOUBLE HETEROZYGOUS CARRIERS OF FACTOR V LEIDEN AND PROTHROMBIN G20210A
W. M. Lijfering* (NL), N. J. G. M. Veeger, S. Middeldorp, K. Hamulyák, M. H. Prins, H. R. Büller, J. van der Meer
Chairpersons: Henny Billett (US) and Gun Jorneskog (SE)
OC-WE-101 4:00 PM - 4:15 PM
LMWH BRIDGING IN ATRIAL FIBRILLATION
H. H. Billett* (US), E. R. Giannattasio, B. A. Scorizello, H. W. Cohen
OC-WE-102 4:15 PM - 4:30 PM
GENDER DIFFERENCES IN STROKE RISK OF ATRIAL FIBRILLATION PATIENTS ON ORAL ANTICOAGULANT TREATMENT
D. Poli* (IT), E. Antonucci, E. Grifoni, G. Ciuti, R. Marcucci, L. Mannini, G. F. Gensini, R. Abbate, D. Prisco
4:45 PM - 5:00 PM
RISK OF RECURRENT VENOUS THROMBOSIS IN HOMOZYGOUS CARRIERS, AND DOUBLE HETEROZYGOUS CARRIERS OF FACTOR V LEIDEN AND PROTHROMBIN G20210A
W. M. Lijfering* (NL), N. J. G. M. Veeger, S. Middeldorp, K. Hamulyák, M. H. Prins, H. R. Büller, J. van der Meer
Chairpersons: Henny Billett (US) and Gun Jorneskog (SE) OC-WE-101 4:00 PM - 4:15 PM
LMWH BRIDGING IN ATRIAL FIBRILLATION
H. H. Billett* (US), E. R. Giannattasio, B. A. Scorizello, H. W. Cohen
OC-WE-102 4:15 PM - 4:30 PM
GENDER DIFFERENCES IN STROKE RISK OF ATRIAL FIBRILLATION PATIENTS ON ORAL ANTICOAGULANT TREATMENT
D. Poli* (IT), E. Antonucci, E. Grifoni, G. Ciuti, R. Marcucci, L. Mannini, G. F. Gensini, R. Abbate, D. Prisco
OC-WE-103
4:30 PM - 4:45 PM
PREVALENCE, CHARACTERISTICS AND MORTALITY RATES OF INDIVIDUALS ELIGIBLE FOR LIPID LOWERING USING THE JUPITER CRITERIA IN A GENERAL POPULATION SAMPLE
M. Cushman* (US), L. A. McClure, S. G. Lakoski, N. S. Jenny
4:30 PM - 4:45 PM
PREVALENCE, CHARACTERISTICS AND MORTALITY RATES OF INDIVIDUALS ELIGIBLE FOR LIPID LOWERING USING THE JUPITER CRITERIA IN A GENERAL POPULATION SAMPLE
M. Cushman* (US), L. A. McClure, S. G. Lakoski, N. S. Jenny
OC-WE-104
4:45 PM - 5:00 PM
EFFECTS OF ATORVASTATIN ON HAEMOSTASIS IN PATIENTS WITH TYPE 1 DIABETES
S. Tehrani* (SE), F. Mobarrez, A. Antovic, P. Santesson, P. Lins, U. Adamson, P. Henriksson, H. Wallén, G. Jörneskog
Chairpersons: Javier Corral (ES) and Ulrike Nowak-Gottl (DE)
4:45 PM - 5:00 PM
EFFECTS OF ATORVASTATIN ON HAEMOSTASIS IN PATIENTS WITH TYPE 1 DIABETES
S. Tehrani* (SE), F. Mobarrez, A. Antovic, P. Santesson, P. Lins, U. Adamson, P. Henriksson, H. Wallén, G. Jörneskog
Chairpersons: Javier Corral (ES) and Ulrike Nowak-Gottl (DE)
OC-WE-105
4:00 PM - 4:15 PM
A PIVOTAL ROLE OF PROTEASE-ACTIVATED RECEPTOR-2 IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS
K. S. Borensztajn* (NL), P. Bresser, J. von der Thusen, B. van den Blink, A. P. Groot, J. Daalhuisen, M. P. Peppelenbosch, A. Spek
4:00 PM - 4:15 PM
A PIVOTAL ROLE OF PROTEASE-ACTIVATED RECEPTOR-2 IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS
K. S. Borensztajn* (NL), P. Bresser, J. von der Thusen, B. van den Blink, A. P. Groot, J. Daalhuisen, M. P. Peppelenbosch, A. Spek
OC-WE-106
4:15 PM - 4:30 PM
A PREDICTIVE MODEL FOR INDENTIFYING CHILDREN AT RISK FOR SYMPTOMATIC THROMBOEMBOLISM DURING ACUTE LYMPHOBLASTIC LEUKEMIA TREATMENT – RESULTS OF A MULTICENTER COHORT STUDY
S. Flege, L. Mitchell, G. Kenet, M. Fruhwald, R. Schobess, U. Nowak-Gottl* (DE)
4:15 PM - 4:30 PM
A PREDICTIVE MODEL FOR INDENTIFYING CHILDREN AT RISK FOR SYMPTOMATIC THROMBOEMBOLISM DURING ACUTE LYMPHOBLASTIC LEUKEMIA TREATMENT – RESULTS OF A MULTICENTER COHORT STUDY
S. Flege, L. Mitchell, G. Kenet, M. Fruhwald, R. Schobess, U. Nowak-Gottl* (DE)
OC-WE-107
4:30 PM - 4:45 PM
DEXAMETHASONE INDUCES A HEAT-STRESS RESPONSE THAT AMELIORATES THE CONFORMATIONAL CONSEQUENCES ON ANTITHROMBIN OF L-ASPARAGINASE TREATMENT AND HELPS TO EXPLAIN THE REDUCED RISK OF THROMBOSIS
D. Hernández-Espinosa, A. Miñano, A. Ordóñez, R. Mota, I. Martínez-Martínez, V. Vicente, J. Corral* (ES)
4:30 PM - 4:45 PM
DEXAMETHASONE INDUCES A HEAT-STRESS RESPONSE THAT AMELIORATES THE CONFORMATIONAL CONSEQUENCES ON ANTITHROMBIN OF L-ASPARAGINASE TREATMENT AND HELPS TO EXPLAIN THE REDUCED RISK OF THROMBOSIS
D. Hernández-Espinosa, A. Miñano, A. Ordóñez, R. Mota, I. Martínez-Martínez, V. Vicente, J. Corral* (ES)
OC-WE-108
4:45 PM - 5:00 PM
DEFIBROTIDE BLUNTS THE PRO-THROMBOTIC EFFECT OF THALIDOMIDE ON ENDOTHELIAL CELLS
C. Echart, S. Somaini, P. G. Richardson, J. Fareed* (US), M. Iacobelli
Chairpersons: Edward Pryzdial (CA) and Eric Mullins (US)
OC-WE-109
4:00 PM - 4:15 PM
REGULATION OF MOUSE THROMBIN-ACTIVABLE FIBRINOLYSIS INHIBITOR GENE EXPRESSION BY INFLAMMATORY CYTOKINES
M. Garand* (CA), N. Jiang, C. E. Hill, M. L. Koschinsky, M. B. Boffa
OC-WE-110 4:15 PM - 4:30 PM
EPIGENETIC CONTROL OF TISSUE-TYPE PLASMINOGEN ACTIVATOR EXPRESSION BY HUMAN ENDOTHELIAL CELLS
S. Dunoyer-Geindre* (CH), E. K. O. Kruithof
4:45 PM - 5:00 PM
DEFIBROTIDE BLUNTS THE PRO-THROMBOTIC EFFECT OF THALIDOMIDE ON ENDOTHELIAL CELLS
C. Echart, S. Somaini, P. G. Richardson, J. Fareed* (US), M. Iacobelli
Chairpersons: Edward Pryzdial (CA) and Eric Mullins (US)
OC-WE-109
4:00 PM - 4:15 PM
REGULATION OF MOUSE THROMBIN-ACTIVABLE FIBRINOLYSIS INHIBITOR GENE EXPRESSION BY INFLAMMATORY CYTOKINES
M. Garand* (CA), N. Jiang, C. E. Hill, M. L. Koschinsky, M. B. Boffa
OC-WE-110 4:15 PM - 4:30 PM
EPIGENETIC CONTROL OF TISSUE-TYPE PLASMINOGEN ACTIVATOR EXPRESSION BY HUMAN ENDOTHELIAL CELLS
S. Dunoyer-Geindre* (CH), E. K. O. Kruithof
OC-WE-111
4:30 PM - 4:45 PM
PLASMIN FORMATION ON NEURONS STIMULATES THE RELEASE OF NEURON-DERIVED MICROPARTICLES BEARING PROTEOLYTIC ACTIVITY
L. Doeuvre* (FR), L. Plawinski, O. Nicole, D. Goux, F. Toti, E. Anglés-Cano
4:30 PM - 4:45 PM
PLASMIN FORMATION ON NEURONS STIMULATES THE RELEASE OF NEURON-DERIVED MICROPARTICLES BEARING PROTEOLYTIC ACTIVITY
L. Doeuvre* (FR), L. Plawinski, O. Nicole, D. Goux, F. Toti, E. Anglés-Cano
OC-WE-112
4:45 PM - 5:00 PM
RBC-BOUND PLASMINOGEN ACTIVATORS INITIATE AND PROPAGATE EFFICIENT FIBRINOLYSIS
K. C. Gersh* (US), S. Zaitsev, D. B. Cines, V. Muzykantov, J. W. Weisel
Chairpersons: Peter Grant (UK) and Christina Jern (SE)
4:45 PM - 5:00 PM
RBC-BOUND PLASMINOGEN ACTIVATORS INITIATE AND PROPAGATE EFFICIENT FIBRINOLYSIS
K. C. Gersh* (US), S. Zaitsev, D. B. Cines, V. Muzykantov, J. W. Weisel
Chairpersons: Peter Grant (UK) and Christina Jern (SE)
OC-WE-113
4:00 PM - 4:15 PM
DETERMINANTS OF CAROTID INTIMA-MEDIA THICKNESS AMONG HIV POSITIVE PERSONS: A THREE YEARS PROSPECTIVE COHORT STUDY
E. Fourn, E. Pasquier, A. Delluc* (FR), L. Bressollette, L. de Saint Martin
4:00 PM - 4:15 PM
DETERMINANTS OF CAROTID INTIMA-MEDIA THICKNESS AMONG HIV POSITIVE PERSONS: A THREE YEARS PROSPECTIVE COHORT STUDY
E. Fourn, E. Pasquier, A. Delluc* (FR), L. Bressollette, L. de Saint Martin
OC-WE-114
4:15 PM - 4:30 PM
FIBRIN STRUCTURE/FUNCTION IN RELATION TO STROKE SUB-TYPES AND POST-STROKE MORTALITY
A. M. Carter* (UK), D. Kirby, N. A. Englyst, R. A. Ajjan, J. M. Bamford, C. Byrne, P. J. Grant
4:15 PM - 4:30 PM
FIBRIN STRUCTURE/FUNCTION IN RELATION TO STROKE SUB-TYPES AND POST-STROKE MORTALITY
A. M. Carter* (UK), D. Kirby, N. A. Englyst, R. A. Ajjan, J. M. Bamford, C. Byrne, P. J. Grant
OC-WE-115
4:30 PM - 4:45 PM
PLASMA LEVELS OF VON WILLEBRAND FACTOR IN ETIOLOGICAL SUBTYPES OF ISCHEMIC STROKE
E. Hanson* (SE), K. Jood, P. Redfors, S. Nilsson, C. Blomstrand, C. Jern
4:30 PM - 4:45 PM
PLASMA LEVELS OF VON WILLEBRAND FACTOR IN ETIOLOGICAL SUBTYPES OF ISCHEMIC STROKE
E. Hanson* (SE), K. Jood, P. Redfors, S. Nilsson, C. Blomstrand, C. Jern
OC-WE-116
4:45 PM - 5:00 PM
IS COAGULATION ACTIVATION A RISK FACTOR FOR COGNITIVE DECLINE IN OLDER PEOPLE?
G. D. O. Lowe* (UK), D. J. Stott, A. Rumley, P. Welsh, M. Robertson, I. Ford, N. Sattar, R. Westendorp, T. J. M. de Craen, J. Shepherd
Chairpersons: Wolfgang Schramm (DE) and Barbara Konkle (US)
4:45 PM - 5:00 PM
IS COAGULATION ACTIVATION A RISK FACTOR FOR COGNITIVE DECLINE IN OLDER PEOPLE?
G. D. O. Lowe* (UK), D. J. Stott, A. Rumley, P. Welsh, M. Robertson, I. Ford, N. Sattar, R. Westendorp, T. J. M. de Craen, J. Shepherd
Chairpersons: Wolfgang Schramm (DE) and Barbara Konkle (US)
OC-WE-117
4:00 PM - 4:15 PM
EVIDENCE FOR INCREASED INHIBITOR INCIDENCE IN CHILDREN WITH SEVERE HEMOPHILIA A TREATED WITH RECOMBINANT FACTOR VIII PRODUCTS: A SYSTEMATIC REVIEW&META-ANALYSIS
S. Halimeh* (DE), C. Bindlingmaier, C. Escuriola Ettinghausen, N. Goldenberg, S. Holzhauer, G. Kenet, K. Kurnik, D. Manner, U. Nowak-Goettl
4:00 PM - 4:15 PM
EVIDENCE FOR INCREASED INHIBITOR INCIDENCE IN CHILDREN WITH SEVERE HEMOPHILIA A TREATED WITH RECOMBINANT FACTOR VIII PRODUCTS: A SYSTEMATIC REVIEW&META-ANALYSIS
S. Halimeh* (DE), C. Bindlingmaier, C. Escuriola Ettinghausen, N. Goldenberg, S. Holzhauer, G. Kenet, K. Kurnik, D. Manner, U. Nowak-Goettl
OC-WE-118
4:15 PM - 4:30 PM
MANAGEMENT OF HAEMOPHILIA PATIENTS WITH INHIBITORS: OPTIMAL CARE IN TIMES OF LIMITED RESOURCES
K. Berger* (DE), D. Eheberg, W. Schramm
4:15 PM - 4:30 PM
MANAGEMENT OF HAEMOPHILIA PATIENTS WITH INHIBITORS: OPTIMAL CARE IN TIMES OF LIMITED RESOURCES
K. Berger* (DE), D. Eheberg, W. Schramm
OC-WE-119
4:30 PM - 4:45 PM
THE EUROPEAN STUDY OF CLINICAL, HEALTH ECONOMIC AND QUALITY OF LIFE OUTCOMES IN 1,426 HAEMOPHILIA PATIENTS
W. Schramm* (DE), K. Berger, B. Bullinger, A. Crispin, P. Giangrande, A. Giebl, A. Gringeri, R. Ljung, L. Nemes, S. von Mackensen, L. Mantovani, M. Serban
4:30 PM - 4:45 PM
THE EUROPEAN STUDY OF CLINICAL, HEALTH ECONOMIC AND QUALITY OF LIFE OUTCOMES IN 1,426 HAEMOPHILIA PATIENTS
W. Schramm* (DE), K. Berger, B. Bullinger, A. Crispin, P. Giangrande, A. Giebl, A. Gringeri, R. Ljung, L. Nemes, S. von Mackensen, L. Mantovani, M. Serban
OC-WE-120
4:45 PM - 5:00 PM
IMPROVED CONCEPT OF FACTOR IX ALBUMIN FUSION PROTEINS
H. J. Metzner* (DE), T. Weimer, U. Kronthaler, W. Lang, S. Schulte
Chairpersons: Peter Newman (US) and Steven W. Kerrigan (IE)
4:45 PM - 5:00 PM
IMPROVED CONCEPT OF FACTOR IX ALBUMIN FUSION PROTEINS
H. J. Metzner* (DE), T. Weimer, U. Kronthaler, W. Lang, S. Schulte
Chairpersons: Peter Newman (US) and Steven W. Kerrigan (IE)
OC-WE-121
4:00 PM - 4:15 PM
FIBRINOGEN-BETA3 INTEGRIN INTERACTION IS REQUIRED FOR MAINTENANCE OF PLATELET P-SELECTIN EXPRESSION
H. Yang, S. Lang* (CA), Z. Zhai, L. Li, W. H. A. Kahr, P. Chen, J. Brkic, C. M. Spring, M. J. Flick, J. L. Degen, J. Freedman, H. Ni
4:00 PM - 4:15 PM
FIBRINOGEN-BETA3 INTEGRIN INTERACTION IS REQUIRED FOR MAINTENANCE OF PLATELET P-SELECTIN EXPRESSION
H. Yang, S. Lang* (CA), Z. Zhai, L. Li, W. H. A. Kahr, P. Chen, J. Brkic, C. M. Spring, M. J. Flick, J. L. Degen, J. Freedman, H. Ni
OC-WE-122
4:15 PM - 4:30 PM
THE ROLE OF PI 3-KBETA IN GLYCOPROTEIN VI-MEDIATED AKT ACTIVATION IN PLATELETS
S. Kim* (US), P. Mangin, C. Dangelmaier, R. Lillian, S. P. Jackson, J. L. Daniel, S. P. Kunapuli
4:15 PM - 4:30 PM
THE ROLE OF PI 3-KBETA IN GLYCOPROTEIN VI-MEDIATED AKT ACTIVATION IN PLATELETS
S. Kim* (US), P. Mangin, C. Dangelmaier, R. Lillian, S. P. Jackson, J. L. Daniel, S. P. Kunapuli
OC-WE-123
4:30 PM - 4:45 PM
DIVERGENT ROLES OF CONVENTIONAL AND NOVEL PKC ISOFORMS IN PLATELET ACTIVATION TOWARDS THROMBUS FORMATION
K. Gilio* (NL), M. T. Harper, J. M. E. M. Cosemans, K. J. Hall, O. Konopatskaya, I. C. A. Munnix, J. D. Molkentin, M. Leitges, J. W. M. Heemskerk, A. W. Poole
4:30 PM - 4:45 PM
DIVERGENT ROLES OF CONVENTIONAL AND NOVEL PKC ISOFORMS IN PLATELET ACTIVATION TOWARDS THROMBUS FORMATION
K. Gilio* (NL), M. T. Harper, J. M. E. M. Cosemans, K. J. Hall, O. Konopatskaya, I. C. A. Munnix, J. D. Molkentin, M. Leitges, J. W. M. Heemskerk, A. W. Poole
OC-WE-124
4:45 PM - 5:00 PM
IDENTIFICATION OF A RHEOLOGICAL-DEPENDENT MECHANISM STABILIZING DISCOID PLATELET AGGREGATION INDEPENDENT OF SOLUBLE AGONISTS E. Westein* (AU), W. S. Nesbitt, F. Jia, S. P. Jackson
Chairpersons: Sandip Kanse (DE) and Virgilio Evangelista (IT)
4:45 PM - 5:00 PM
IDENTIFICATION OF A RHEOLOGICAL-DEPENDENT MECHANISM STABILIZING DISCOID PLATELET AGGREGATION INDEPENDENT OF SOLUBLE AGONISTS E. Westein* (AU), W. S. Nesbitt, F. Jia, S. P. Jackson
Chairpersons: Sandip Kanse (DE) and Virgilio Evangelista (IT) OC-WE-125
4:00 PM - 4:15 PM
FXIIIa ADOPTS A PERINUCLEAR DISTRIBUTION IN MONOCYTIC-CELLS AND TRANSFECTED COS CELLS
P. A. Cordell* (UK), P. J. Grant, R. J. Pease
OC-WE-126
4:15 PM - 4:30 PM
PLATELET SOLUBLE MEDIATORS INDUCE A MONOCYTE GENE EXPRESSION PROFILE THAT IS ANTI-INFLAMMATORY, ANTITHROMBOTIC AND PRO-ANGIOGENIC
J. R. Wright, U. Krishnan, R. Farrugia, N. A. Watkins, P. Ellis, C. Langford, W. H. Ouwehand, A. H. Goodall* (UK)
4:15 PM - 4:30 PM
PLATELET SOLUBLE MEDIATORS INDUCE A MONOCYTE GENE EXPRESSION PROFILE THAT IS ANTI-INFLAMMATORY, ANTITHROMBOTIC AND PRO-ANGIOGENIC
J. R. Wright, U. Krishnan, R. Farrugia, N. A. Watkins, P. Ellis, C. Langford, W. H. Ouwehand, A. H. Goodall* (UK)
OC-WE-127
4:30 PM - 4:45 PM
NEUTROPHILS PHAGOCYTOSE ACTIVATED PLATELETS IN VIVO: A PHOSPHATIDYLSERINE, P-SELECTIN AND ß2 INTEGRIN-DEPENDENT CELL CLEARANCE PROGRAM
N. Maugeri* (IT), P. Rovere-Querini, A. Capobianco, L. Totani, V. Evangelista, A. Maseri, A. A. Manfredi
4:30 PM - 4:45 PM
NEUTROPHILS PHAGOCYTOSE ACTIVATED PLATELETS IN VIVO: A PHOSPHATIDYLSERINE, P-SELECTIN AND ß2 INTEGRIN-DEPENDENT CELL CLEARANCE PROGRAM
N. Maugeri* (IT), P. Rovere-Querini, A. Capobianco, L. Totani, V. Evangelista, A. Maseri, A. A. Manfredi
OC-WE-128
4:45 PM - 5:00 PM
FACTOR SEVEN ACTIVATING PROTEASE (FSAP) – INFLAMMATION AND COAGULATION CROSS-TALK IN PATIENTS WITH CORONARY ARTERY DISEASE
M. Parahuleva, R. Maj, A. Staubitz, H. Hoelscherman, H. Tillmanns, A. Erdogan, S. Kanse* (DE)
Chairpersons: J. Evan Sadler (US) and Luca Lotta (IT)
4:45 PM - 5:00 PM
FACTOR SEVEN ACTIVATING PROTEASE (FSAP) – INFLAMMATION AND COAGULATION CROSS-TALK IN PATIENTS WITH CORONARY ARTERY DISEASE
M. Parahuleva, R. Maj, A. Staubitz, H. Hoelscherman, H. Tillmanns, A. Erdogan, S. Kanse* (DE)
Chairpersons: J. Evan Sadler (US) and Luca Lotta (IT)
OC-WE-129
4:00 PM - 4:15 PM
TITLE: OBJECTIVE DOCUMENTATION OF NEUROLOGIC INJURYIN PATIENTS WITH IDIOPATHIC THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)
S. R. Cataland* (US), J. Paskavitz, P. Maruff, L. Witkoff, M. Jin, J. C. Gilbert, H. M. Wu
OC-WE-130 4:15 PM - 4:30 PM
LONGITUDINAL PERFORMANCES OF ADAMTS13 ANTIGEN AND ACTIVITY OVER THE COURSE OF IDIOPATHIC TTP
S. Yang, M. Jin, S. Lin, S. R. Cataland, H. M. Wu* (US)
OC-WE-131 4:30 PM - 4:45 PM
INFLUENCE OF THE VON WILLEBRAND FACTOR (VWF) SUBSTRATE ON ADAMTS13 ACTIVITY MEASUREMENT
R. Palla* (IT), C. Valsecchi, M. Spreafico, M. T. Bajetta, F. Peyvandi
4:00 PM - 4:15 PM
TITLE: OBJECTIVE DOCUMENTATION OF NEUROLOGIC INJURYIN PATIENTS WITH IDIOPATHIC THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)
S. R. Cataland* (US), J. Paskavitz, P. Maruff, L. Witkoff, M. Jin, J. C. Gilbert, H. M. Wu
OC-WE-130 4:15 PM - 4:30 PM
LONGITUDINAL PERFORMANCES OF ADAMTS13 ANTIGEN AND ACTIVITY OVER THE COURSE OF IDIOPATHIC TTP
S. Yang, M. Jin, S. Lin, S. R. Cataland, H. M. Wu* (US)
OC-WE-131 4:30 PM - 4:45 PM
INFLUENCE OF THE VON WILLEBRAND FACTOR (VWF) SUBSTRATE ON ADAMTS13 ACTIVITY MEASUREMENT
R. Palla* (IT), C. Valsecchi, M. Spreafico, M. T. Bajetta, F. Peyvandi
OC-WE-132
4:45 PM - 5:00 PM
INFLUENCE OF ADAMTS13 GENOTYPE ON THE AGE OF ONSET OF CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)
L. A. Lotta* (IT), I. Garagiola, R. Palla, A. Cairo, R. Klaassen, A. Metin, A. Gurgey, F. Peyvandi
Chairperson: Emmanuel Favaloro (AU)
4:45 PM - 5:00 PM
INFLUENCE OF ADAMTS13 GENOTYPE ON THE AGE OF ONSET OF CONGENITAL THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)
L. A. Lotta* (IT), I. Garagiola, R. Palla, A. Cairo, R. Klaassen, A. Metin, A. Gurgey, F. Peyvandi
Chairperson: Emmanuel Favaloro (AU)
OC-WE-133
4:00 PM - 4:15 PM
REDUCED VWF SURVIVAL IN TWO LARGE COHORTS OF TYPE 1 VWD PATIENTS FROM THE CANADIAN TYPE 1 VWD AND US VWD (ZPMCB-VWD) STUDIES
S. L. Haberichter* (US), P. D. James, P. A. Christopherson, D. Lillicrap, R. R. Montgomery, for the Canadian Type 1 VWD and ZPMCB-VWD Study
4:00 PM - 4:15 PM
REDUCED VWF SURVIVAL IN TWO LARGE COHORTS OF TYPE 1 VWD PATIENTS FROM THE CANADIAN TYPE 1 VWD AND US VWD (ZPMCB-VWD) STUDIES
S. L. Haberichter* (US), P. D. James, P. A. Christopherson, D. Lillicrap, R. R. Montgomery, for the Canadian Type 1 VWD and ZPMCB-VWD Study
OC-WE-134
4:15 PM - 4:30 PM
CANADIAN PLATELET-TYPE VON WILLEBRAND DISEASE (PT-VWD) PROJECT: PROGRESS AND UPDATE
M. Othman* (CA), M. C. Ozelo, H. Brown, J. Leggo, C. Notley, E. J. Favaloro, S. Enayat, J. P. Frontroth, A. Angelillo, H. Smith, J. Olson, D. Lillicrap
4:15 PM - 4:30 PM
CANADIAN PLATELET-TYPE VON WILLEBRAND DISEASE (PT-VWD) PROJECT: PROGRESS AND UPDATE
M. Othman* (CA), M. C. Ozelo, H. Brown, J. Leggo, C. Notley, E. J. Favaloro, S. Enayat, J. P. Frontroth, A. Angelillo, H. Smith, J. Olson, D. Lillicrap
OC-WE-135
4:30 PM - 4:45 PM
USE OF IN SILICO AND IN VITRO ANALYSIS TO IDENTIFY VWF 5’ REGULATORY ELEMENTS
D. J. Hampshire* (UK), P. R. Winship, D. Lillicrap, I. R. Peake, A. C. Goodeve, on behalf of the EU-VWD and ZPMCB-VWD Study Groups
4:30 PM - 4:45 PM
USE OF IN SILICO AND IN VITRO ANALYSIS TO IDENTIFY VWF 5’ REGULATORY ELEMENTS
D. J. Hampshire* (UK), P. R. Winship, D. Lillicrap, I. R. Peake, A. C. Goodeve, on behalf of the EU-VWD and ZPMCB-VWD Study Groups
OC-WE-136
4:45 PM - 5:00 PM
HOMOZYGOUS R854W VON WILLEBRAND FACTOR IS POORLY SECRETED AND CAUSES A SEVERE VON WILLEBRAND DISEASE PHENOTYPE
G. Castaman* (IT), S. Giacomelli, T. Obser, U. Budde, R. Schneppenheim, F. Rodeghiero
Chairpersons: John-Bjarne Hansen (NO) and David Green (US)
4:45 PM - 5:00 PM
HOMOZYGOUS R854W VON WILLEBRAND FACTOR IS POORLY SECRETED AND CAUSES A SEVERE VON WILLEBRAND DISEASE PHENOTYPE
G. Castaman* (IT), S. Giacomelli, T. Obser, U. Budde, R. Schneppenheim, F. Rodeghiero
Chairpersons: John-Bjarne Hansen (NO) and David Green (US)
OC-WE-137
4:00 PM - 4:15 PM
IMPACT OF SERUM OSTEOPROTEGERIN AND SRANKL ON CAROTID ATHEROSCLEROTIC PLAQUE FORMATION AND GROWTH IN A GENERAL POPULATION – THE TROMSØ STUDY
A. Vik, E. Mathiesen, S. Johnsen, J. Brox, T. Wilsgaard, I. Njølstad, J. Hansen* (NO)
4:00 PM - 4:15 PM
IMPACT OF SERUM OSTEOPROTEGERIN AND SRANKL ON CAROTID ATHEROSCLEROTIC PLAQUE FORMATION AND GROWTH IN A GENERAL POPULATION – THE TROMSØ STUDY
A. Vik, E. Mathiesen, S. Johnsen, J. Brox, T. Wilsgaard, I. Njølstad, J. Hansen* (NO)
OC-WE-138
4:15 PM - 4:30 PM
ENDOGENOUS THROMBIN POTENTIAL IS ASSOCIATED WITH CAROTID INTIMA MEDIA THICKNESS IN SUBJECTS YOUNGER THAN 45 YEARS
H. Bernhard* (AT), P. Wipfler, B. Leschnik, J. Kraus, M. Novak, G. Pilz, G. Ladurner, W. Muntean
4:15 PM - 4:30 PM
ENDOGENOUS THROMBIN POTENTIAL IS ASSOCIATED WITH CAROTID INTIMA MEDIA THICKNESS IN SUBJECTS YOUNGER THAN 45 YEARS
H. Bernhard* (AT), P. Wipfler, B. Leschnik, J. Kraus, M. Novak, G. Pilz, G. Ladurner, W. Muntean
OC-WE-139
4:30 PM - 4:45 PM
INTERLEUKIN-6 GENE POLYMORPHISMS IN ASIAN INDIAN FAMILIES WITH PREMATURE CORONARY ARTERY DISEASE
A. Maitra* (IN), J. Shanker, D. Dash, S. John, P. R. Sannappa, V. S. Rao, V. V. Kakkar
4:30 PM - 4:45 PM
INTERLEUKIN-6 GENE POLYMORPHISMS IN ASIAN INDIAN FAMILIES WITH PREMATURE CORONARY ARTERY DISEASE
A. Maitra* (IN), J. Shanker, D. Dash, S. John, P. R. Sannappa, V. S. Rao, V. V. Kakkar
OC-WE-140
4:45 PM - 5:00 PM
RELATIONS BETWEEN SERUM OSTEOPROTEGERIN AND CAROTID INTIMA MEDIA THICKNESS IN A GENERAL POPULATION – THE TROMSØ STUDY
A. Vik, E. Mathiesen, S. Johnsen, J. Brox, T. Wilsgaard, I. Njølstad, J. Hansen* (NO)
Chairpersons: Bjorn Dahlback (SE) and Jasimuddin Ahamed (US)
4:45 PM - 5:00 PM
RELATIONS BETWEEN SERUM OSTEOPROTEGERIN AND CAROTID INTIMA MEDIA THICKNESS IN A GENERAL POPULATION – THE TROMSØ STUDY
A. Vik, E. Mathiesen, S. Johnsen, J. Brox, T. Wilsgaard, I. Njølstad, J. Hansen* (NO)
Chairpersons: Bjorn Dahlback (SE) and Jasimuddin Ahamed (US)
OC-WE-141
4:00 PM - 4:15 PM
IMPORTANCE OF PROTEIN S FOR EXPRESSION OF THE C4B-BINDING PROTEIN -?-CHAIN
S. U. Carlsson* (SE), B. Dahlbäck
4:00 PM - 4:15 PM
IMPORTANCE OF PROTEIN S FOR EXPRESSION OF THE C4B-BINDING PROTEIN -?-CHAIN
S. U. Carlsson* (SE), B. Dahlbäck
OC-WE-142
4:15 PM - 4:30 PM
MODULATION OF ACTIVATED PROTEIN C CYTOPROTECTIVE EFFECTS BY CELLULAR THERAPY USING GPI-LINKED ENDOTHELIAL CELL PROTEIN C RECEPTOR
L. O. Mosnier* (US)
OC-WE-143 4:30 PM - 4:45 PM
ACTIVATED PROTEIN C PREVENTS THE NF-KB ACTIVATION AT GLUTAMATE- AND THROMBIN- INDUCED TOXICITY
S. Strukova* (RU), L. Gorbacheva, I. Savinkova, V. Pinelis, S. Ishiwata, G. Reiser
OC-WE-144
4:45 PM - 5:00 PM
PROTEIN C DEPLETION ENHANCES BACTERIAL OUTGROWTH AND INFLAMMATION IN MURINE E. COLI PERITONITIS
M. Schouten* (NL), C. van ‘T Veer, C. T. Esmon, M. M. Levi, T. van der Poll
Chairpersons: Margareta Blomback (SE) and Sheryl Bowley (US)
OC-WE-145
4:00 PM - 4:15 PM
IMPAIRED POLYMERIZATION OF FIBRINOGEN GAMMA-N308K IS DUE TO ALTERED D:D AND “A:A” INTERACTIONS
S. R. Bowley* (US), N. Okumura, S. T. Lord
4:15 PM - 4:30 PM
MODULATION OF ACTIVATED PROTEIN C CYTOPROTECTIVE EFFECTS BY CELLULAR THERAPY USING GPI-LINKED ENDOTHELIAL CELL PROTEIN C RECEPTOR
L. O. Mosnier* (US)
OC-WE-143 4:30 PM - 4:45 PM
ACTIVATED PROTEIN C PREVENTS THE NF-KB ACTIVATION AT GLUTAMATE- AND THROMBIN- INDUCED TOXICITY
S. Strukova* (RU), L. Gorbacheva, I. Savinkova, V. Pinelis, S. Ishiwata, G. Reiser
OC-WE-144
4:45 PM - 5:00 PM
PROTEIN C DEPLETION ENHANCES BACTERIAL OUTGROWTH AND INFLAMMATION IN MURINE E. COLI PERITONITIS
M. Schouten* (NL), C. van ‘T Veer, C. T. Esmon, M. M. Levi, T. van der Poll
Chairpersons: Margareta Blomback (SE) and Sheryl Bowley (US) OC-WE-145
4:00 PM - 4:15 PM
IMPAIRED POLYMERIZATION OF FIBRINOGEN GAMMA-N308K IS DUE TO ALTERED D:D AND “A:A” INTERACTIONS
S. R. Bowley* (US), N. Okumura, S. T. Lord
OC-WE-146
4:15 PM - 4:30 PM
STRUCTURAL BASIS FOR FIBRIN MECHANICAL PROPERTIES AND ITS POTENTIAL CLINICAL SIGNIFICANCE
A. E. X. Brown, R. I. Litvinov, D. E. Discher, P. K. Purihit, J. W. Weisel* (US)
OC-WE-147
4:30 PM - 4:45 PM
FORCED RUPTURE OF FIBRIN ‘A-A’ KNOB-HOLE INTERACTION IS ACCOMPANIED BY UNFOLDING IN THE DISTAL D REGION OF THE MOLECULE
O. V. Gorkun* (US), L. E. Averett, B. B. Akhremitchev, M. H. Schoenfisch
OC-WE-148
4:45 PM - 5:00 PM
FIBRINOGEN SHAPE IN SOLUTION: A MULTI-RESOLUTION STUDY
B. Cardinali* (IT), C. Rosano, A. Profumo, O. Byron, M. Roessle, N. Volkmann, M. Rocco
Chairperson: Hansjorg Schwertz (US)
OC-WE-149
4:00 PM - 4:15 PM
DYNAMIC UPREGULATION OF HUMAN PLATELET PRODUCTION BY HIGH SHEAR RATES
C. Dunois-Larde, C. Capron, S. Fichelson, E. Cramer-Borde, D. Baruch* (FR)
4:00 PM - 4:15 PM
DYNAMIC UPREGULATION OF HUMAN PLATELET PRODUCTION BY HIGH SHEAR RATES
C. Dunois-Larde, C. Capron, S. Fichelson, E. Cramer-Borde, D. Baruch* (FR)
OC-WE-150
4:15 PM - 4:30 PM
ABNORMAL MEGAKARYOCYTE AND PROPLATELET FORMATION IN MEGAKARYOCYTE-RESTRICTED MYH9 INACTIVATION
A. Eckly, C. Strassel, M. Freund, J. Cazenave, F. Lanza, C. Gachet, C. Léon* (FR)
4:15 PM - 4:30 PM
ABNORMAL MEGAKARYOCYTE AND PROPLATELET FORMATION IN MEGAKARYOCYTE-RESTRICTED MYH9 INACTIVATION
A. Eckly, C. Strassel, M. Freund, J. Cazenave, F. Lanza, C. Gachet, C. Léon* (FR)
OC-WE-151
4:30 PM - 4:45 PM
CLINICAL IMPLICATIONS OF THE NEGATIVE PARACRINE EFFECT OF PLATELET FACTOR 4 (PF4) ON THROMBOPOIETIN (TPO) TREATMENT IN RADIATION-INDUCED THROMBOCYTOPENIA (RIT)
M. P. Lambert* (US), Y. Nguyen, M. A. Kowalska, M. Poncz
4:30 PM - 4:45 PM
CLINICAL IMPLICATIONS OF THE NEGATIVE PARACRINE EFFECT OF PLATELET FACTOR 4 (PF4) ON THROMBOPOIETIN (TPO) TREATMENT IN RADIATION-INDUCED THROMBOCYTOPENIA (RIT)
M. P. Lambert* (US), Y. Nguyen, M. A. Kowalska, M. Poncz
OC-WE-152
4:45 PM - 5:00 PM
GENE EXPRESSION DIFFERENCES BETWEEN FETAL LIVER AND ADULT BONE MARROW-DERIVED MURINE MEGAKARYOCYTE PROGENITORS: IMPLICATIONS FOR DOWN SYNDROME MEGAKARYOBLASTIC LEUKEMIA
K. Wieland, A. B. Cantor* (US)
4:45 PM - 5:00 PM
GENE EXPRESSION DIFFERENCES BETWEEN FETAL LIVER AND ADULT BONE MARROW-DERIVED MURINE MEGAKARYOCYTE PROGENITORS: IMPLICATIONS FOR DOWN SYNDROME MEGAKARYOBLASTIC LEUKEMIA
K. Wieland, A. B. Cantor* (US)