ISTH 2009
 
               

Scientific Program

Chairperson: Roy Silverstein (US)
Protection from Cardiovascular Disease: Getting to the Heart of the Matter PL-MO-001
Helen H. Hobbs (US) 9:45 – 10:30 AM


Chairperson: Mary Cushman (US)
Thromboprophylaxis as a key patient safety priority: Current approaches and future directions PL-MO-002
William H. Geerts (CA) 5:15 - 6:00 PM


Chairpersons: Phillip Wells (CA) and Samuel Goldhaber (US)
Short term prognosis of pulmonary embolism SA-MO-001
Drahomir Aujesky (CH) 11:00 - 11:30 AM
Treatment strategies including thrombolysis  
and embolectomy SA-MO-002
Samuel Goldhaber (US) 11:30 - 12:00 PM
Diagnostic management of pulmonary embolism SA-MO-003
Menno Huisman (NL) 12:00 - 12:30 PM

Chairpersons: Kenneth Kanushansky (US) and Joseph Italiano (US)
Empirical and theoretical phenotypic  
discrimination in hemostasis SA-MO-004
Kathleen Brummel-Ziedins (US) 11:00 - 11:30 AM
Systems biology of platelets and coagulation SA-MO-005
Scott Diamond (US) 11:30 - 12:00 PM
Selective sorting of platelet ?-granule contents SA-MO-006
Joseph Italiano (US) 12:00 - 12:30 PM
Chairpersons: Robert Montgomery (US) and Cécile Dennis (FR)
Reduced von Willebrand factor survival in von
Willebrand disease: Pathophysiological
and clinical relevance SA-MO-007
Giancarlo Castaman (IT) 11:00 - 11:30 AM
Mouse models of von Willebrand disease SA-MO-008
Cécile Denis (FR) 11:30 - 12:00 PM
Genotype/phenotype association in von Willebrand  
disease: Is the glass half full or half empty? SA-MO-009
David Lillicrap (CA) 12:00 - 12:30 PM
Chairpersons: Charles Esmon (US) and Hartmut Weiler (US)
Critical roles for thrombin in acute and chronic
inflammation SA-MO-010
Anthony Dorling (UK) 11:00 - 11:30 AM
Dendritic cells and PAR signaling in Inflammation SA-MO-011
Wolfram Ruf (US) 11:30 - 12:00 PM
Modulation of sepsis with activated protein C variants SA-MO-012
Hartmut Weiler (US) 12:00 - 12:30 PM
 
Chairpersons: Christel Van Geet (BE) and Charles Abrams (US)
Altered megakaryopoiesis in Type IIb von  
Willebrand disease SA-MO-013
Alan Nurden (FR) 11:00 - 11:30 AM
Regulation of platelets biogenesis SA-MO-014
Ramesh Shivdasani (US) 11:30 - 12:00 PM
Lesions in platelet signaling SA-MO-015
Christel Van Geet (BE) 12:00 - 12:30 PM
Chairpersons: William Aird (US) and Susan Smyth (US)
Systems approach to inflammation resolution: Identification of novel anti-inflammatory and pro-resolving lipid mediators SA-MO-016
Charles N. Serhan (US) 11:00 - 11:30 AM
Molecular control of angiogenesis and remodeling
SA-MO-017
William Sessa (US) 11:30 - 12:00 PM
Regulation of vascular cell function by bioactive l ysolipids SA-MO-018
Susan Smyth (US) 12:00 - 12:30 PM

Abstract Symposia consist of an invited speaker and four highly rated abstracts presented on a related general theme

 
Chairperson: Saskia Middeldorp (NL)
Thrombophilia testing in asymptomatic family members:  
More harm than good? AS-MO-001
Saskia Middeldorp (NL) 2:15 - 2:45 PM
AS-MO-002
2:45 - 3:00 PM

A PROSPECTIVE COHORT STUDY ON THE ABSOLUTE RISK OF VENOUS THROMBOEMBOLISM IN ASYMPTOMATIC SUBJECTS WITH HEREDITARY DEFICIENCIES OF PROTEIN S, PROTEIN C OR ANTITHROMBIN
B. K. Mahmoodi* (NL), J. Brouwer, M. ten Kate, W. Lijfering, N. Veeger, H. Kluin-Nelemans, J. van der Meer

AS-MO-003
3:00 - 3:15 PM
MORTALITY IN THROMBOPHILIA: A CONTROLLED EVALUATION FROM THE EUROPEAN PROSPECTIVE COHORT ON THROMBOPHILIA (EPCOT)
I. Pabinger* (AT), C. Y. Vossen, J. Lang, J. Conard, C. García-Dabrio, W. Miesbach, G. Palareti, P. Svensson, A. Kaider, F. R. Rosendaal

AS-MO-004
3:15- 3:30 PM

RISK OF RECURRENCE AMONG HETEROZYGOUS CARRIERS OF FACTOR II (FII) G20210A AND A FIRST UNPROVOKED VENOUS THROMBOEMBOLISM (VTE)
G. Hron* (AT), L. Eischer, S. Eichinger, P. A. Kyrle

AS-MO-005
3:30 - 3:45 PM
MULTIPLE SNP TESTING TO PREDICT RISK OF FIRST VENOUS THROMBOSIS
I. D. Bezemer* (NL), C. J. M. Doggen, S. Le Cessie, P. H. Reitsma, L. A. Bare, F. R. Rosendaal

Chairperson: Thomas Wakefield (US)
Aggressive therapies for DVT AS-MO-006
Thomas Wakefield (US) 2:15 - 2:45 PM

AS-MO-007
2:45 - 3:00 PM
ADDITIONAL CATHETER-DIRECTED VENOUS THROMBOLYSIS IN ILIOFEMORAL DEEP VEIN THROMBOSIS; SHORT-TERM RESULTS FROM THE CAVENT STUDY, A MULTIleft, RANDOMIZED CONTROLLED TRIAL
T. R. Enden* (NO), C. E. Slagsvold, N. E. Kløw, P. M. Sandset

AS-MO-008
3:00 - 3:15 PM

ILIOFEMORAL VENOUS THROMBOSIS SUCCESSFULLY TREATED WITH CATHETER-DIRECTED THROMBOLYSIS
M. Jørgensen* (DK), S. Just, R. Broholm, N. Bækgaard, L. Panduro

AS-MO-009
3:15 - 3:30 PM

THE PAVIA ENDARTERECTOMY PROGRAM FOR THE MANAGEMENT OF PULMONARY ENDARTERECTOMY (PEA) IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTEPH)

F. Piovella* (IT), A. M. D’Armini, M. Barone, V. Emmi, C. Beltrametti, M. Viganò

AS-MO-010
3:30 - 3:45 PM

CLINICAL SAFETY, EFFICACY & PHARMACOKINETICS OF INTRA-CLOT TPA FOR LOWER EXTREMITY DVT
J. N. Lozier* (US), R. Chang

Chairperson: Jo’se Lo’pez (US)
ADAMTS13, TTP and related disorders AS-MO-011
Jose Lopez (US) 2:15 - 2:45 PM

AS-MO-012
2:45 - 3:00 PM
CRYSTAL STRUCTURE OF THE EXOSITES-CONTAINING FRAGMENT OF ADAMTS13
M. Akiyama* (JP), S. Takeda, K. Kokame, J. Takagi, T. Miyata

AS-MO-013
3:00 - 3:15 PM
MOLECULAR MODELLING OF ADAMTS-13 METALLOPROTEINASE DOMAIN
R. de Cristofaro* (IT), S. Lancellotti, N. Pozzi, V. de Filippis

AS-MO-014
3:15 - 3:30 PM
UNPRODUCTIVE BINDING OF ADAMTS13 TO VON WILLEBRAND FACTOR
H. B. Feys* (BE), P. J. Anderson, K. Vanhoorelbeke, J. E. Sadler

AS-MO-015
3:30 - 3:45 PM
AMINO ACID RESIDUES R660, R661 AND Y662 WITHIN THE SPACER DOMAIN OF ADAMTS13 ARE ESSENTIAL FOR RECOGNITION AND CLEAVAGE OF VON WILLEBRAND FACTOR
S. Jin* (US), X. Zheng

Chairperson: Peter Lenting (NL)
Biology of von Willebrand factor AS-MO-016
Peter Lenting (NL) 2:15 - 2:45 PM
AS-MO-017
2:45 - 3:00 PM
CLEARANCE OF VON WILLEBRAND FACTOR (VWF) IN TYPE 2 VON WILLEBRAND DISEASE (VWD): THE IMPLICATIONS OF VWF PROPEPTIDE (VWFPP) AND VWF:AG LEVELS
S. L. Haberichter* (US), G. Castaman, P. D. James, P. A. Christopherson, F. Roheghiero, D. Lillicrap, R. R. Montgomery, for Canadian Vicenza and ZPMCB-VWD Study Groups

AS-MO-018
3:00 - 3:15 PM

EXPRESSION OF HUMAN TYPE 2B VON WILLEBRAND DISEASE MUTANTS IN THE VWF KO MOUSE MODEL M. Golder* (CA), C. M. Pruss, C. Hegadorn, K. Laverty, K. Sponagle, D. Lillicrap

AS-MO-019
3:15 - 3:30 PM
ASSOCIATIONS BETWEEN THE VON WILLEBRAND FACTOR GENE (VWF) VARIANT C.2771G>A (P.R924Q), VON WILLEBRAND FACTOR ANTIGEN (VWF:AG) AND FVIII ACTIVITY (FVIII:C) LEVELS AND ITS ROLE AS A RISK FACTOR FOR TYPE 1 VON WILLEBRAND DISEASE (VWD)
N. Hickson* (UK), D. J. Hampshire, P. R. Winship, P. D. James, I. R. Peake, A. C. Goodeve, on behalf of the EUVWD and ZPMCB-VWD Study Groups

AS-MO-020
3:30 - 3:45 PM
THE IMPACT OF VON WILLEBRAND FACTOR SEQUENCE CHANGES THAT AFFECT ADAMTS13MEDIATED CLEAVAGE IN THE VWF KNOCKOUT MOUSE MODEL
C. M. Pruss* (CA), M. Golder, C. Hegadorn, K. Laverty, K. Sponagle, C. Notley, Y. Chirinian, D. Lillicrap


Chairperson: George Broze (US)
Protein Z and ZPI: An update AS-MO-021
George Broze (US) 2:15 - 2:45 PM

AS-MO-022
2:45 - 3:00 PM
ACTIVATED PROTEIN C (APC) INHIBITS INFLAMMATION AND APOPTOSIS BY REGULATING ENDOPLASMIC RETICULUM (ER) STRESS
L. J. Toltl* (CA), R. C. Austin, P. C. Y. Liaw

AS-MO-023
3:00 - 3:15 PM
CRYSTAL STRUCTURES SHOW HOW PROTEIN Z CATALYSES ZPI INHIBITION OF FXa ON PHOSPHOLIPID SURFACES
Z. Wei, Y. Yan, A. Zhou* (UK)

AS-MO-024
3:15 - 3:30 PM
PLATELET TISSUE FACTOR PATHWAY INHIBITOR (TFPI) PREVENTS HEPATIC AND CEREBRAL FIBRIN DEPOSITION IN MOUSE TISSUES AND LIMITS THROMBUS GROWTH
S. A. Maroney* (US), J. P. Ferrel, B. C. Cooley, A. E. Mast

AS-MO-025
3:30 - 3:45 PM

MECHANISMS OF COFACTOR-ASSISTED PROTEASE INHIBITION BY PROTEIN C INHIBITOR
W. Li* (UK), J. A. Huntington

Chairperson: Rezan Kadir (UK)
Women and bleeding disorders: New perspectives AS-MO-026
Rezan Kadir (UK) 2:15 - 2:45 PM

AS-MO-027
2:45 - 3:00 PM
INITIAL DEPLOYMENT OF A COMPREHENSIVE, ONTOLOGY-BACKED, WEB-BASED BLEEDING HISTORY PHENOTYPING INSTRUMENT IN NORMAL INDIVIDUALS
A. C. Mauer* (US), E. M. Barbour, N. A. Khazanov, N. Levenkova, S. A. Mollah, B. S. Coller

AS-MO-028
3:00 - 3:15 PM
ESTABLISHMENT OF A EUROPEAN NETWORK OF RARE BLEEDING DISORDERS (EN-RBD DATABASE): PRELIMINARY RESULTS ON 190 PATIENTS
M. Menegatti* (IT), R. Palla, S. M. Siboni, M. Benedik-Dolnicar, C. Bidlingmaier, T. Celkan, P. Giangrande, R. Gilmore, J. Ingerslev, K. Peerlink, H. Pergantou, F. Suzan, M. Spreafico, R. Waha, P. Lanzi, F. Peyvandi

AS-MO-029
3:15 - 3:30 PM

PREGNANCY AND DELIVERY IN WOMEN WITH VON WILLEBRAND DISEASE AND DIFFERENT VON WILLEBRAND FACTOR MUTATIONS
G. Castaman* (IT), A. Tosetto, F. Rodeghiero

AS-MO-030
3:30 - 3:45 PM
RISK OF POSTPARTUM HEMORRHAGE IN WOMEN RECEIVING THERAPEUTIC DOSES OF LOWMOLECULAR-WEIGHT HEPARIN
S. Roshani* (NL), D. M. Cohn, A. Stehouwer, S. Hamers, H. Wolf, J. M. van der Post, H. R. Büller, P. W. Kamphuisen, S. Middeldorp


Chairperson: Jerry Ware (US)
The platelet paradigm in cancer AS-MO-031
Jerry Ware (US) 2:15 - 2:45 PM

AS-MO-032
2:45 - 3:00 PM
THE EFFECT OF P2Y-MEDIATED ACTIVATION ON VEGF AND ENDOSTATIN RELEASE FROM PLATELETS
N. M. Bambace* (US), J. E. Levis, C. E. Holmes

AS-MO-033
3:00 - 3:15 PM

AN ASSOCIATION BETWEEN ANTI-PLATELET DRUG USE AND REDUCED CANCER PREVALENCE IN DIABETIC PATIENTS: RESULTS FROM THE VERMONT DIABETES INFORMATION SYSTEM
C. E. Holmes* (US), M. E. Ramos-Nino, B. Littenberg

AS-MO-034
3:15 - 3:30 PM
GENETIC VARIANTS OF PLATELET FUNCTION AND CANCER MORTALITY: A FOLLOW-UP STUDY
J. D. Snoep* (NL), C. E. Holmes, F. R. Rosendaal, J. G. van der Bom

AS-MO-035
3:30 - 3:45 PM
PLASMA LEVELS OF MICROPARTICLE ASSOCIATED TISSUE FACTOR ACTIVITY IN PATIENTS WITH CLINICALLY SUSPECTED PULMONARY EMBOLISM WITH OR WITHOUT CANCER
P. Garcia Rodriguez* (NL), H. C. J. Eikenboom, M. E. T. Tesselaar, M. V. Huisman, M. Nijkeuter, S. Osanto, R. M. Bertina

Chairperson: Angel Garcia (ES)
Novel strategies in platelet research: The proteomics approach AS-MO-036
Angel Garcia, (ES) 2:15 - 2:45 PM

AS-MO-037
2:45 - 3:00 PM
DEFINING THE FUNCTION OF NOVEL PLATELET GENES USING A LASER THROMBOSIS MODEL IN DANIO RERIO
I. I. Salles* (BE), M. N. O’Connor, A. Cvejic, N. A. Watkins, P. Burns, A. Walker, S. F. Garner, C. I. Jones, I. C. Macaulay, M. Steward, J. Zwaginga, S. L. Bray, F. Dudbridge, B. de Bono, A. H. Goodall, H. Deckmyn, D. L. Stemple, W. H. Ouwehand, on behalf of the Bloodomics consortium

AS-MO-038
3:00 - 3:15 PM

THE IDENTIFICATION OF ABI-1 AS NEW VASP EVH1 DOMAIN INTERACTING PARTNER IN HUMAN PLATELETS BASED ON THE “PLATELETWEB” KNOWLEDGE BASE
M. Dittrich, V. Strassberger, T. Jarchau, P. Tas, U. Lewandrowski, T. Dandekar, U. Walter, I. Birschmann* (DE)

AS-MO-039
3:15 - 3:30 PM
STUDY OF BIMOLECULAR INTEGRIN-FIBRINOGEN INTERACTIONS UNDER A CONSTANT UNBINDING FORCE
R. I. Litvinov* (US), H. Shuman, J. W. Weisel, J. S. Bennett

AS-MO-040
3:30 - 3:45 PM

RAPID ADHESION KINETICS OF PLATELETS UNDER VERY HIGH SHEAR

D. N. Ku* (US), A. N. Para, D. L. Bark


Chairperson: Diego Mezzano (CL)
Regulation of platelet-expressed tissue factor AS-MO-041
Diego Mezzano (CL) 2:15 - 2:45 PM

AS-MO-042
2:45 - 3:00 PM
CELLULAR SOURCES OF TISSUE FACTOR THAT CONTRIBUTE TO ACTIVATION OF COAGULATION IN ENDOTOXEMIC MICE
R. Pawlinski* (US), N. Mackman

AS-MO-043
3:00 - 3:15 PM

ENDOTHELIAL TISSUE FACTOR CONTRIBUTES TO FIBRIN GENERATION DURING THROMBUS FORMATION IN LIVING MICE SUBJECTED TO LASER INJURY
V. M. Chen* (US), T. H. David, G. Merrill-Skoloff, N. Mackman, S. R. Coughlin, B. C. Furie, B. Furie

AS-MO-044
3:15 - 3:30 PM

LEVELS OF MICROPARTICLE TISSUE FACTOR ACTIVITY CORRELATE WITH COAGULATION ACTIVATION IN ENDOTOXEMIC MICE
J. Wang* (US), D. Manly, D. Kirchhofer, R. Pawlinski, N. Mackman

AS-MO-045
3:30 - 3:45 PM
INHIBITION OF PROTEIN DISULPHIDE ISOMERASE ON ENDOTHELIAL CELLS ENHANCES COAGULATION THROUGH PHOSPHATIDYLSERINE EXPOSURE
N. I. Popescu* (US), C. Lupu, F. Lupu

Chairperson: Mark Ginsberg (US)
Dynamic regulation of cell-cell adhesion AS-MO-046
Mark Ginsberg (US) 2:15 - 2:45 PM
   
AS-MO-047
2:45 - 3:00 PM
SEROTONIN STIMULATES PLATELET RECEPTOR SHEDDING BY TUMOR NECROSIS FACTORALPHA-CONVERTING ENZYME (ADAM17)
D. Duerschmied* (US), M. Canault, D. Lievens, A. Brill, S. Cifuni, M. Bader, D. D. Wagner

AS-MO-048
3:00 - 3:15 PM
CADHERIN 6 MODULATES PLATELET FUNCTION THROUGH INTEGRIN αIIBβ3
E. Dunne* (IE), M. C. Berndt, D. J. Kenny

AS-MO-049
3:15 - 3:30 PM

TARGETING ONGOING ARTERIAL THROMBOSIS WITH PLATELET-SPECIFIC MICROPARTICLES
Z. M. Ruggeri* (US), J. N. Orje, B. Molins, S. Harvey, S. Mitragorti, J. Smith

AS-MO-050
3:30 - 3:45 PM

GI24R: A NOVEL MEMBER OF IMMUNOGLOBULIN RECEPTOR ON PLATELETS
U. J. H. Sachs, S. Jessen, B. Kehrel, K. Clemetson, S. Santoso* (DE)

Chairperson: Sherrill Slichter (US)
Current advances in platelet transfusion therapy AS-MO-051
Sherrill Slichter (US) 2:15 - 2:45 PM

AS-MO-052
2:45 - 3:00 PM

MODIFIED MONOCLONAL PLATELET ANTIBODIES PREVENT ANTIBODY-MEDIATED CLEARANCE OF HUMAN PLATELETS IN AN IN VIVO MODEL OF IMMUNE THROMBOCYTOPENIA T. Bakchoul* (DE), B. Boylan, G. Bein, S. Santoso, P. J. Newman

AS-MO-053
3:00 - 3:15 PM
THE ALPHA2 INTEGRIN (GPIA) POLYMORPHISM: THE NEW PLATELET ALLOANTIGEN CABA AND 6 NEW MUTATIONS
G. Bertrand* (FR), V. Jallu, D. Saillant, D. Kervran, C. Martageix, C. Kaplan

AS-MO-054
3:15 - 3:30 PM

ASSESSMENT OF GENOTYPE-PHENOTYPE RELATIONSHIP FOR SIX COMMON PLATELET POLYMORPHISMS IN 286 HEALTHY SUBJECTS

C. Martínez, A. I. Antón, J. Corral, T. Quiroga, O. Panes, M. L. Lozano, R. González-Conejero, R. Teruel, L. Navarro-Núñez, J. Pereira, N. Navarro, D. Mezzano, V. Vicente, J. Rivera* (ES)

AS-MO-055
3:30 - 3:45 PM

A PHASE III, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY (RAISE) OF ELTROMBOPAG FOR THE TREATMENT OF CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA (ITP)
G. Cheng, M. N. Saleh, J. B. Bussel* (US), C. Marcher, S. Vasey, B. Mayer, M. Aivado, M. Arning, N. L. Stone

Chairperson: Ulrich Von Andrian (US)
Mechanisms and consequences of dendritic AS-MO-056
cell migration  
Ulrich Von Andrian (US) 2:15 - 2:45 PM

AS-MO-057
2:45 - 3:00 PM
PECAM-1 POLYMORPHISM IN IG DOMAIN 6 (S536N) PLAYS A ROLE IN TRANSENDOTHELIAL MIGRATION OF NEUTROPHILS
B. Bayat* (DE), S. Werth, C. Andrei-Selmer, P. Newman, S. Santoso

AS-MO-058
3:00 - 3:15 PM

A ROLE OF THE ENDOTHELIAL P2Y1 RECEPTOR IN MONOCYTE ADHESION TO AND TRANSMIGRATION ACROSS MURINE MICROVASCULAR ENDOTHELIAL CELLS IN VITRO
M. Zerr-Fouineau* (FR), B. Hechler, I. Lanois, J. Cazenave, C. Gachet

AS-MO-059
3:15 - 3:30 PM

HYPERCOAGULABILITY PROMOTES PLAQUE STABILITY DURING ATHEROGENESIS BY INHIBITING MONOCYTE MIGRATION THROUGH A PAR-1, PLC-BETA, PI3K, AND NO-DEPENDENT MECHANISM
K. Shahzad, S. Seehaus, I. Vinnikov, H. Wang, M. Kashif, M. Thati, P. P. Nawroth, B. Isermann* (DE)

AS-MO-060
3:30 - 3:45 PM

CD146 AND ITS SOLUBLE FORM REGULATE MONOCYTE TRANSENDOTHELIAL MIGRATION
N. Bardin* (FR), M. Blot-Chabaud, N. Despoix, A. Kebir, K. Harhouri, F. Vely, F. Dignat George


Chairperson: Holger Gerhardt (UK)
Molecular control of angiogenic sprouting AS-MO-061
Holger Gerhardt (UK) 2:15 - 2:45 PM

AS-MO-062
2:45 - 3:00 PM
VITRONECTIN PROMOTES ISCHEMIA-INDUCED ANGIOGENESIS
J. Wu* (US), W. P. Fay


AS-MO-063
3:00 - 3:15 PM
ALTERNATIVELY SPLICED TISSUE FACTOR PROMOTES ANGIOGENESIS THROUGH INTEGRIN LIGATION
Y. W. van den Berg* (NL), L. G. van den Hengel, H. R. Myers, O. Ayachi, K. (JO)ova, W. Ruf, A. C. Spek, P. H. Reitsma, H. H. Versteeg

AS-MO-064
3:15 - 3:30 PM

ANGIOGENIC SIGNALING BY RAP1B IN ENDOTHELIAL CELLS INVOLVES ACTIVATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 AND INTEGRIN ALPHAV/BETA3
M. Chrzanowska-Wodnicka* (US)

AS-MO-065
3:30 - 3:45 PM

IDENTIFICATION OF UPREGULATED PROANGIOGENIC GENES IN INTIMAL NEOVESSELS FROM HUMAN ADVANCED ATHEROSCLEROTIC PLAQUES USING LASER-CAPTURE MICROSCOPE M. M. Turu* (ES), L. Badimon, A. Luque, M. Baldellou, N. Rovira, J. Krupinski, M. Slevin