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Scientific Program
Chairperson: Sriram Krishnaswamy (US)
| von Willebrand factor assembly and secretion | PL-TH-001 |
| J. Evan Sadler (US) | 9:45 - 10:30 AM |
Chairperson: Charles Abrams (US)
| Stem cells, pluripotency, and nuclear reprogramming | PL-TH-002 |
| Rudolf Jaenisch (US) | 5:15 - 6:00 PM |
Chairpersons: Henri Bounameaux (CH) and Trevor Baglin (US)
| What happens after venous thromboembolism? | SA-TH-001 |
| Trevor Baglin (UK) | 11:00 - 11:30 AM |
| Risk assessment to predict recurrence | SA-TH-002 |
| Sabine Eichinger (AT) | 11:30 - 12:00 PM |
| Balancing risks and benefits of extended | |
| anticoagulation | SA-TH-003 |
| Clive Kearon (US) | 12:00 - 12:30 PM |
Chairpersons: Marco Cattaneo (IT) and Alan Michelson (US)
| The evolution of platelet-directed pharmacotherapy | SA-TH-004 |
| Richard Becker (US) | 11:00 - 11:30 AM |
| New P2Y12 antagonists | SA-TH-005 |
| Marco Cattaneo (IT) | 11:30 - 12:00 PM |
| Aspirin: 110 years later | SA-TH-006 |
| Carlo Patrono (IT) | 12:00 - 12:30 PM |
Chairpersons: Keith McCrae (US) and Lena Claesson-Welsh (SE)
Embryonic stem cell-derived endothelial cells:
| Properties and potential | SA-TH-007 |
| Lena Claesson-Welsh (SE) | 11:00 - 11:30 AM |
| Regulation of stem cell niche by endothelium | SA-TH-008 |
| Shahin Rafii (US) | 11:30 - 12:00 PM |
| Defining and characterizing human endothelial | |
| progenitor cells | SA-TH-009 |
| Marvin Yoder (US) | 12:00 - 12:30 PM |
Chairpersons: Michael Greaves (UK) and Marcel Levi (NL)
| Bleeding with the new anticoagulants: Management options | SA-TH-0010 |
| Mark Crowther (CA) | 11:00 - 11:30 AM |
| Prediction and management of bleeding after cardiac surgery | SA-TH-0011 |
| George Despotis (US) | 11:30 - 12:00 PM |
| Epidemiology and management of bleeding in patients using vitamin K antagonists | SA-TH-0012 |
| Marcel Levi (NL) | 12:00 - 12:30 PM |
Chairpersons: Bernhardt Nieswandt (DE) and Garret FitzGerald (US) | Bioactive lipids and atherothrombosis | SA-TH-013 |
| Garret A FitzGerald (US) | 11:00 - 11:30 AM |
| The role of the intrinsic apoptosis pathway in plateletbiogenesis, life and death | SA-TH-014 |
| Benjamin Kile (AU) | 11:30 - 12:00 PM |
| Platelet hyperreactivity, scavenger receptors and | |
| atherothrombosis | SA-TH-0015 |
| Eugene Podrez (US) | 12:00 - 12:30 PM |
Chairpersons: Kenneth Mann (US) and Tilman Hackeng (NL)
| Regulation of TFPI function by protein S | SA-TH-0016 |
| Tilman Hackeng (NL) | 11:00 - 11:30 AM |
| Protease allostery in hemostasis | SA-TH-0017 |
| James Huntington (UK) | 11:30 - 12:00 PM |
| Blood clotting reactions on nanoscale bilayers | SA-TH-0018 |
| James Morrissey (US) | 12:00 - 12:30 PM |
Abstract Symposia consist of an invited speaker and four highly rated abstracts presented on a related general theme
Chairperson: Joseph Emmerich (FR) | Estrogens and vascular disease: Non-oral postmenopausal hormones and risk of thrombosis | AS-TH-001 |
|---|---|
| Joseph Emmerich (FR) | 2:15 - 2:45 PM |
AS-TH-002
2:45 - 3:00 PM
THE RISK OF VENOUS THROMBOSIS ASSOCIATED WITH NON-ORAL HORMONAL CONTRACEPTIVES
A. van Hylckama Vlieg* (NL), F. M. Helmerhorst, J. P. Vandenbroucke, C. J. M. Doggen, F. R. Rosendaal
AS-TH-003
3:00 - 3:15 PM
IS PROGESTERONE AN INDEPENDENT RISK FACTOR FOR INCIDENT VENOUS THROMBOEMBOLISM (VTE)? A POPULATION-BASED CASE-CONTROL STUDY
M. Barsoum, J. A. Heit* (US), A. A. Ashrani, C. L. Leibson, T. M. Petterson, K. R. Bailey, L. J. Melton III
AS-TH-004
3:15 - 3:30 PM
DIFFERENTIAL IMPACT OF CONVENTIONAL AND LOW DOSE ORAL HORMONE THERAPY (HT) ON SEX HORMONE BINDING GLOBULIN (SHBG)
A. L. Eilertsen* (NO), E. Hoibraaten, C. M. Lofthus, M. C. Mowinckel, P. M. Sandset
AS-TH-005
3:30 - 3:45 PM
DOES PATIENT SEX AND PRIOR HORMONAL THERAPY PREDICT RISK FOR THROMBOSIS RECURRENCE AFTER A FIRST VENOUS THROMBOEMBOLISM?
J. Douketis* (CA), A. Iorio, M. Marcucci, T. Baglin, M. Cushman, S. Eichinger, G. Palareti, D. Poli, C. Tait, A. Tosetto
Chairperson: Gowthami Arepally (US) | Heparin-induced thrombocytopenia: Insights from murine models | AS-TH-006 |
|---|---|
| Gowthami Arepally (US) | 2:15 - 2:45 PM |
AS-TH-007
2:45 - 3:00 PM
PLATELET FACTOR 4 BINDS TO GRAM POSITIVE BACTERIA AND INDUCES ANTIBODIES CROSSREACTING WITH PF4/HEPARIN
K. Krauel* (DE), C. Pötschke, B. Fürll, W. Keßler, J. Bagemühl, B. M. Bröker, A. Greinacher
AS-TH-008
3:00 - 3:15 PM
A MODEL OF HOW PLATELET FACTOR 4 (PF4) CONTRIBUTES TO PHYSIOLOGIC AND PATHOLOGIC THROMBOSIS
M. A. Kowalska* (US), T. Turoczi, J. Hirsch, L. Rauova, D. Cines, H. Weiler, R. Camire, S. Krishnaswamy, M. Poncz
AS-TH-009
3:15 - 3:30 PM
ANTIBODY-INDEPENDENT, ALPHAIIBBETA3-MEDIATED ACTIVATION OF HUMAN PLATELETS BY UNFRACTIONATED HEPARIN
C. Gao* (US), B. Boylan, J. Fang, D. A. Wilcox, D. K. Newman, P. J. Newman
AS-TH-010
3:30 - 3:45 PM
SIGNIFICANCE OF HIGH CONCENTRATION OF HEPARIN-INDUCED PLATELET ANTIBODIES
K. M. Javela, R. Kekomäki* Finland, S. Koskinen
Chairperson: Claude G. Negrier (FR)
| Can we improve upon nature to design products with enhanced efficacy for treating hemophilia and von Willebrand disease? | AS-TH-011 |
|---|---|
| Claude G. Negrier (FR) | 2:15 - 2:45 PM |
AS-TH-012
2:45 - 3:00 PM
REPEAT ORAL ADMINISTRATION OF CHITOSAN FVIII DNA NANOPARTICLES RESULTS IN FVIII ANTIGEN IN BLOOD OF HEMOPHILIA A MICE
S. S. Dhadwar* (CA), J. Wen, G. Hortelano
AS-TH-013
3:00 - 3:15 PM
ZYMOGEN-LIKE FACTOR Xa VARIANTS IMPROVE HEMOSTASIS IN HEMOPHILIA MICE
L. Ivanciu* (US), R. Toso, A. Schlachterman, H. Downey, J. Liu, V. R. Arruda, R. M. Camire
AS-TH-014
3:15 - 3:30 PM
FACTOR IX VARIANTS WITH FACTOR VIII INHIBITOR BYPASSING ACTIVITY
J. Schuettrumpf* (DE), P. Milanov, D. Abriss, T. Tonn, E. Seifried
AS-TH-015
3:30 - 3:45 PM
DEVELOPMENT OF A NOVEL TENASE-BYPASSING AGENT WITH A PROLONGED HALF-LIFE IN VIVO
P. Gueguen* (FR), G. Cherel, L. Panicot-Dubois, R. Pendu, I. Badirou, C. Dubois, C. V. Denis, O. D. Christophe
Chairperson: Michael Mendelsohn (US)
| Estrogen signaling in endothelium | AS-TH-016 |
|---|---|
| Michael Mendelsohn (US) | 2:15 - 2:45 PM |
AS-TH-017
2:45 - 3:00 PM
ENDOGENOUS PROTEIN C IS ESSENTIAL FOR THE FUNCTIONAL INTEGRITY OF HUMAN ENDOTHELIAL CELLS
M. Xue, N. Minhas, P. N. Sambrook, L. March, C. J. Jackson* (AU)
AS-TH-018
3:00 - 3:15 PM
VISCERAL STROMAL SECRETOME INDUCES ENDOTHELIAL DAMAGE AND ACTIVATION IN OBESITY
M. Palomo* (ES), F. Hanzu, P. Molina, P. Gomez, M. Garaulet, G. Escolar, R. Gomis, M. Diaz-Ricart
AS-TH-019
3:15 - 3:30 PM
METABOLIC AND VASCULAR CONSEQUENCES OF NEPRILYSIN DEFICIENCY: STUDIES IN A MURINE MODEL
K. F. Standeven* (UK), K. A. Hess, N. Y. Yuldasheva, A. J. Balmforth, S. B. Wheatcroft, N. M. Hooper, P. J. Grant
AS-TH-020 3:30 - 3:45 PM
ACTIVATED FACTOR X CLEAVES PAR1 AND MEDIATES SIGNALING DEPENDENT ON BINDING TO THE ENDOTHELIAL PROTEIN C RECEPTOR
R. A. Schuepbach, M. Riewald* (US)
Chairperson: Christian Gachet (FR)
| Purinergic and other receptors as targets for old and new drugs | AS-TH-021 |
|---|---|
| Christian Gachet (FR) | 2:15 - 2:45 PM |
AS-TH-022
2:45 - 3:00 PM
CLOPIDOGREL AND PRASUGREL PROLONG PRIMARY HEMOSTASIS IN THE MOUSE BEYOND LEVELS ASSOCIATED WITH P2Y12 INHIBITION
P. Andre* (US), F. Deguzman, S. Mills, Y. Pak, M. Inagaki, A. Pandey, S. Hollenbach, D. Phillips, P. Conley
AS-TH-023
3:00 - 3:15 PM
IN VIVO AND IN VITRO EFFECT OF A NEW THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR-1) ANTAGONIST
M. Dumas* (FR), F. Nadal-Wollbold, F. Grelac, M. Aiach, B. Le Grand, P. Gaussem, C. Bachelot-Loza
AS-TH-024
3:15 - 3:30 PM
ANTI-THROMBOTIC DRUG CANDIDATE ALX-0081 SHOWS SUPERIOR PRECLINICAL EFFICACY AND SAFETY COMPARED TO CURRENT MARKETED ANTIPLATELET DRUGS
H. Ulrichts, A. Schoolmeester* (BE), S. Hoefman, M. Lauwereys, P. Casteels, P. Stanssens, J. Baumeister, J. Roodt, P. P. T. de Jaegere, J. Holz
AS-TH-025
3:30 - 3:45 PM
DEVELOPMENT OF RSOLCD39-PSGL AS A NOVEL THERAPEUTIC WITH ANTI-THROMBOTIC AND ANTI-INFLAMMATORY EFFECTS
S. Dezfouli* (AU), X. Zhang, S. Crikis, K. Dwyer, C. Selan, S. Robson, A. D'Apice, P. Cowan, H. Nandurkar
Chairperson: Suresh Vedantham (US)| Best use of vena cava filters | AS-TH-026 |
|---|---|
| Suresh Vedantham (US) | 2:15 - 2:45 PM |
AS-TH-027
2:45 - 3:00 PM
RETRIEVABLE IVC FILTERS ARE NOT BEING RETRIEVED. WHERE IS THE GAP?
D. Bearelly* (US), N. Nagam, R. Chitima-Matsiga, S. Bearelly, O. Dabbagh
AS-TH-028
3:00 - 3:15 PM
INFERIOR VENA CAVA FILTER OCCLUSION AND SYMPTOMATIC VENOUS THROMBOEMBOLISM RISK IN FULLY ANTICOAGULATED PATIENTS: A PROSPECTIVE, OBSERVATIONAL CONTROLLED STUDY
B. Hajduk* (PL), W. Z. Tomkowski, G. Malek, B. L. Davidson
AS-TH-029
3:15 - 3:30 PM
A PROSPECTIVE BLIND STUDY ON DIAGNOSIS AND CLINICAL RISK OF ISOLATED CALF DEEP VEIN THROMBOSIS IN SYMPTOMATIC OUTPATIENTS (THE CALTHRO STUDY; NCT00816920)
G. Palareti* (IT), B. Cosmi, G. Lessiani, G. Rodorigo, G. Guazzaloca, C. Brusi, E. Conti, M. Filippini, M. Sartori, C. Legnani
AS-TH-030
3:30 - 3:45 PM
ABSENCE OF RESIDUAL VEIN THROMBOSIS AFTER AN EPISODE OF IDIOPATHIC DEEP VEIN THROMBOSIS: SHORT-TERM ANTICOAGULATION IS SAFE. THE “EXTENDED DACUS STUDY”
S. M. Siragusa* (IT), A. Malato, G. Saccullo, G. Pizzo, D. Caramazza, L. Lo Coco, G. Baiardi, G. Milio, A. Pinto
Chairperson: Catherine Hayward (CA)| Platelet function tests in the assessment of bleeding problems | AS-TH-031 |
|---|---|
| Catherine Hayward (CA) | 2:15 -2:45 PM |
AS-TH-032
2:45 - 3:00 PM
PREVALENCE AND CHARACTERISTICS OF DUAL NON RESPONSIVENESS TO ASPIRIN AND CLOPIDOGREL IN A COHORT OF 430 STABLE CARDIOVASCULAR PATIENTS. INSIGHT FROM THE ADRIE STUDY ON STABLE CARDIOVASCULAR PATIENTS
P. Fontana* (CH), I. Barazer, C. Castelli, S. Nolli, P. Berdagué, P. Fabbro-Peray, J. Schved, H. Bounameaux, F. Mach, P. de Moerloose, J. Reny
AS-TH-033
3:00 - 3:15 PM
MEAN PLATELET VOLUME AS A PREDICTOR OF CARDIOVASCULAR RISK: A META-ANALYSIS
S. G. Chu, R. C. Becker, P. B. Berger, D. L. Bhatt, J. W. Eikelboom, B. Konkle, E. R. Mohler, J. S. Berger* (US)
AS-TH-034
3:15 - 3:30 PM
CARDIOVASCULAR DEATH AND NONFATAL MYOCARDIAL INFARCTION IN ACUTE CORONARY SYNDROME PATIENTS ARE PREDICTED BY RESIDUAL PLATELET REACTIVITY TO ADP IN THE ABSENCE OF CYP2C19*2 ALLELE: BEYOND GENETIC SCREENING
R. Marcucci* (IT), B. Giusti, A. Gori, R. Paniccia, C. Saracini, A. Vestrini, C. Nanna, A. Cordisco, E. Antonucci, G. Gensini, R. Abbate
AS-TH-035
3:30 - 3:45 PM
GENETIC VARIANTS OF PLATELET FUNCTION AND CARDIOVASCULAR EVENTS: RESULTS FROM THE SMILE-PLATELETS PROJECT
J. D. Snoep* (NL), J. Emmerich, P. Gaussem, J. C. J. Eikenboom, J. J. Zwaginga, H. L. Vos, P. G. de Groot, F. R. Rosendaal, J. G. van der Bom
Chairperson: Alvin Schmaier (US)| Animal models of the plasma kallikrein/kinin system: Modulation of arterial thrombosis | AS-TH-036 |
|---|---|
| Alvin Schmaier (US) | 2:15 - 2:45 PM |
AS-TH-037
2:45 - 3:00 PM
FACTOR XII IS A NOVEL MITOGENIC FACTOR FOR LUNG FIBROBLASTS IN LUNG FIBROSIS
E. Jablonska* (DE), P. Markart, I. Henneke, T. Renné, A. Günther, K. T. Preissner, M. Wygrecka
AS-TH-038
3:00 - 3:15 PM
MISFOLDED PROTEINS ACTIVATE FACTOR XII IN HUMANS, LEADING TO KALLIKREIN FORMATION WITHOUT INITIATING COAGULATION
C. Maas* (NL), J. W. P. Govers-Riemslag, B. Bouma, B. Schiks, B. P. C. Hazenberg, H. M. Lokhorst, P. Hammarström, H. ten Cate, P. G. de Groot, B. N. Bouma, M. F. B. G. Gebbink
AS-TH-039
3:15 - 3:30 PM
FACTOR XI ACTIVATION BY FACTOR XIIa IN A MURINE THROMBOSIS MODEL
A. Gruber* (US), E. I. Tucker, Q. Cheng, I. Sisler, A. Matafonov, M. Sun, T. Renné, D. Gailani
AS-TH-040
3:30 - 3:45 PM
RHA-INFESTIN, A COAGULATION FACTOR XIIa INHIBITOR, PROTECTS MICE FROM ARTERIAL THROMBOSIS AND ISCHEMIC STROKE WITHOUT IMPAIRING HEMOSTASIS
I. Hagedorn* (DE), U. Kronthaler, I. Pleines, C. Kleinschnitz, G. Stoll, B. Nieswandt
Chairperson: Paul Bray (US)
| Pathways to variation in platelet reactivity | AS-TH-041 |
|---|---|
| Paul Bray (US) | 2:15 - 2:45 PM |
AS-TH-042
2:45 - 3:00 PM
DISRUPTION OF GATA-1/FOG-1 INTERACTION WITH THE NURD COMPLEX RESULTS IN A MACROTHROMBOCYTOPENIA AND ABSENT ALPHA-GRANULES
Y. Wang* (US), A. Miccio, G. D. Gregory, W. Hong, G. A. Blobel, M. Poncz
AS-TH-043
3:00 - 3:15 PM
MYH9-RELATED DISEASE (MYH9-RD), FROM ONE THING TO THE OTHER: 11 NOVEL MUTATIONS AND 3 NEW EXONS AFFECTED
B. Saposnik* (FR), S. Binard, S. Elbaz, C. Trichet, C. Pouplard, V. Roussel-Robert, V. Leymarie, E. de Maistre, B. Royer, N. Djafari, C. Fagnou, H. Charlanne, P. Nurden, A. Nurden, N. Schlegel
AS-TH-044
3:15 - 3:30 PM
RUNX1 REGULATES PLATELET/MEGAKARYOCYTE PKC-THETA : DECREASED PLATELET PKCTHETA EXPRESSION IN HUMAN RUNX1 HAPLODEFICIENCY
G. S. Jalagadugula* (US), G. Kaur, G. Mao, D. Dhanasekaran, A. K. Rao
AS-TH-045
3:30 - 3:45 PM
INDIVIDUALS WITH QUEBEC PLATELET DISORDER HAVE A TANDEM DUPLICATION OF THE UROKINASE PLASMINOGEN ACTIVATOR GENE (PLAU)
A. Paterson, J. Rommens, B. Baraj, I. Wong, J. Blavignac* (CA), M. Diamandis, J. S. Waye, G. E. Rivard, C. P. M. Hayward
Chairperson: Rodney Camire (US)
| Novel factor Xa Variant for improving Hemostesis in Hemophilia | AS-TH-046 |
|---|---|
| Rodney Camire (US) | 2:15 - 2:45 PM |
AS-TH-047
2:45 - 3:00 PM
SUBSTRATE GEOMETRY GOVERNS ACTIVE SITE DOCKING AND REGULATES THE ACTION OF PROTHROMBINASE ON THE TWO CLEAVAGE SITES IN PROTHROMBIN
H. N. Bradford* (US), J. A. Micucci, S. Krishnaswamy
AS-TH-048
3:00 - 3:15 PM
IN-VITRO SELECTION AND CHARACTERISATION OF DNA-APTAMERS THAT SPECIFICALLY BIND TO HUMAN ACTIVATED PROTEIN C
J. Müller* (DE), G. Mayer, B. Isermann, J. Oldenburg, B. Pötzsch
AS-TH-049 3:15 - 3:30 PM
THROMBIN CONTAINS A CRYPTIC LRP BINDING SITE
D. J. D. Johnson* (UK), K. S. Larsen, H. Stennicke, J. A. Huntington
AS-TH-050 3:30 - 3:45 PM
CONFORMATIONAL ACTIVATION OF ZYMOGEN-LIKE THROMBIN VARIANTS BY TIGHT BINDING LIGANDS
A. Khan* (US), P. Panizzi, H. K. Kroh, P. E. Bock, S. Krishnaswamy
Chairperson: Anthony Chan (CA)
| Neonates: Are they more prone to clotting or bleeding? | AS-TH-051 |
|---|---|
| Anthony Chan (CA) | 2:15 - 2:45 PM |
AS-TH-052
2:45 - 3:00 PM
2:45 - 3:00 PM
ROLE OF 18 FUNCTIONAL HEMOSTATIC POLYMORPHISMS IN MUCOCUTANEOUS BLEEDING
A. Antón* (ES), R. González-Conejero, V. Roldán, T. Quiroga, C. Martínez, M. Lozano, L. Navarro-Núñez, B. Sánchez-Vega, J. Rivera, J. Corral, D. Mezzano, V. Vicente
AS-TH-053
3:00 - 3:15 PM
IDENTIFICATION OF CHILDREN WITH SIGNIFICANT MUCOCUTANEOUS BLEEDING: COMPARISON OF THE HOSPITAL FOR SICK CHILDREN (HSC) CRITERIA AND A QUANTITATIVE PEDIATRICSPECIFIC BLEEDING QUESTIONNAIRE (PBQ)
T. T. Biss* (CA), V. S. Blanchette, D. S. Clark, C. D. Wakefield, D. Lillicrap, P. D. James, M. L. Rand
AS-TH-054
3:15 - 3:30 PM
MAJOR HAEMORRHAGE IN NEONATES WITH HAEMOPHILIA, FREQUENCY AND RISK FACTORS. A EUROPEAN COHORT STUDY
M. Richards* (UK), K. Fijnvandraat, G. Lavigne-Lissalde
AS-TH-055
3:30 - 3:45 PM
EVALUATION OF FAMILY HISTORIES IN PEDIATRIC PATIENTS WITH HEREDITARY THROMBOCYTOPATHIES: RESULTS FROM THE THROMKID-STUDY
R. Knoefler* (DE), M. Olivieri, S. Weickardt, W. Eberl, W. Streif
Chairperson: Martin A. Schwartz (US)
AS-TH-057
2:45 - 3:00 PM
VON WILLEBRAND FACTOR SELF-ASSEMBLY UNDER ELEVATED SHEAR STRESS FOSTERS ACTIVATION-INDEPENDENT PLATELET STRING FORMATION
A. J. Reininger* (DE), J. I. Angerer, M. Fallah, M. F. Schneider
AS-TH-058
3:00 - 3:15 PM
FACTOR SEVEN ACTIVATING PROTEASE (FSAP); A KEY REGULATOR OF PERICELLULAR PROTEOLYSIS
J. Daniel, O. Uslu, K. Hersemeyer, O. Rannou, L. Muhl, K. T. Preissner, D. Sedding, S. M. Kanse* (DE)
AS-TH-059
3:15 - 3:30 PM
PHOSPHODIESTERASE-TYPE IV-CAMP-PKA AXIS REGULATES SFK-PYK2 PATHWAY, PMN/ PLATELET ADHESION AND PMN ACCUMULATION AT THE SITE OF VASCULAR INJURY
L. Totani, Z. Pamuklar, A. Piccoli, R. Pecce, L. Federico, N. Martelli, S. Manarini, V. Evangelista, S. S. Smyth* (US)
AS-TH-060
3:30 - 3:45 PM
CD40 LIGAND (CD40L) INCREASES PLATELET THROMBUS STABILITY AND OUTSIDE-IN SIGNALING THROUGH INTEGRIN ALPHAIIB BETA3
R. E. Scharf* (DE), M. Hasse, E. Reiff, M. Gyenes, V. R. Stoldt
A. Antón* (ES), R. González-Conejero, V. Roldán, T. Quiroga, C. Martínez, M. Lozano, L. Navarro-Núñez, B. Sánchez-Vega, J. Rivera, J. Corral, D. Mezzano, V. Vicente
AS-TH-053
3:00 - 3:15 PM
IDENTIFICATION OF CHILDREN WITH SIGNIFICANT MUCOCUTANEOUS BLEEDING: COMPARISON OF THE HOSPITAL FOR SICK CHILDREN (HSC) CRITERIA AND A QUANTITATIVE PEDIATRICSPECIFIC BLEEDING QUESTIONNAIRE (PBQ)
T. T. Biss* (CA), V. S. Blanchette, D. S. Clark, C. D. Wakefield, D. Lillicrap, P. D. James, M. L. Rand
AS-TH-054
3:15 - 3:30 PM
MAJOR HAEMORRHAGE IN NEONATES WITH HAEMOPHILIA, FREQUENCY AND RISK FACTORS. A EUROPEAN COHORT STUDY
M. Richards* (UK), K. Fijnvandraat, G. Lavigne-Lissalde
AS-TH-055
3:30 - 3:45 PM
EVALUATION OF FAMILY HISTORIES IN PEDIATRIC PATIENTS WITH HEREDITARY THROMBOCYTOPATHIES: RESULTS FROM THE THROMKID-STUDY
R. Knoefler* (DE), M. Olivieri, S. Weickardt, W. Eberl, W. Streif
Chairperson: Martin A. Schwartz (US)| Fluid shear stress signaling in endothelial cells: Role of integrins and extracellular matrix | AS-TH-056 |
|---|---|
| Martin A. Schwartz (US) | 2:15 - 2:45 PM |
AS-TH-057
2:45 - 3:00 PM
VON WILLEBRAND FACTOR SELF-ASSEMBLY UNDER ELEVATED SHEAR STRESS FOSTERS ACTIVATION-INDEPENDENT PLATELET STRING FORMATION
A. J. Reininger* (DE), J. I. Angerer, M. Fallah, M. F. Schneider
AS-TH-058
3:00 - 3:15 PM
FACTOR SEVEN ACTIVATING PROTEASE (FSAP); A KEY REGULATOR OF PERICELLULAR PROTEOLYSIS
J. Daniel, O. Uslu, K. Hersemeyer, O. Rannou, L. Muhl, K. T. Preissner, D. Sedding, S. M. Kanse* (DE)
AS-TH-059
3:15 - 3:30 PM
PHOSPHODIESTERASE-TYPE IV-CAMP-PKA AXIS REGULATES SFK-PYK2 PATHWAY, PMN/ PLATELET ADHESION AND PMN ACCUMULATION AT THE SITE OF VASCULAR INJURY
L. Totani, Z. Pamuklar, A. Piccoli, R. Pecce, L. Federico, N. Martelli, S. Manarini, V. Evangelista, S. S. Smyth* (US)
AS-TH-060
3:30 - 3:45 PM
CD40 LIGAND (CD40L) INCREASES PLATELET THROMBUS STABILITY AND OUTSIDE-IN SIGNALING THROUGH INTEGRIN ALPHAIIB BETA3
R. E. Scharf* (DE), M. Hasse, E. Reiff, M. Gyenes, V. R. Stoldt