Chairperson: Nigel Key (US)

Heparin-induced thrombocytopenia	PL-WE-001
Andreas Greinacher (DE)	9:45 - 10:30

Chairpersons: Jay Degen (US) and Katerina Akassoglou (US)

Fibrinogen signal transduction in the nervous system	SA-WE-001
Katerina Akassoglou (US)	11:00 - 11:30 AM
tPA and neurovascular coupling in stroke	SA-WE-002
Daniel Lawrence (US)	11:30 - 12:00 PM
The role of fibrin in Alzheimer's Disease	SA-WE-003
Sidney Strickland (US)	12:00 - 12:30 PM

Abstract Symposia consist of an invited speaker and four highly rated abstracts presented on a related general theme.

Chairperson: Alok Srivastava (IN)

Hemophilia and rare bleeding disorders	AS-WE-001
Alok Srivastava (IN)	2:15 - 2:45 PM

AS-WE-002
2:45 - 3:00 PM
FVIII ASSAY DISCREPANCY - HEMOPHILIA A VARIANTS ESCAPING THE TWO-STAGE ASSAY
H. Brondke* (DE), U. Herbiniaux, J. Oldenburg

AS-WE-003
3:00 - 3:15 PM
LONG TERM (10 YEAR) RESULTS FROM THE CANADIAN HEMOPHILIA PRIMARY PROPHYLAXIS STUDY
V. S. Blanchette* (CA), P. Babyn, A. Chan, R. Card, C. Demers, K. Gill, S. Israels, R. Klaassen, N. Laferriere, D. Lillicrap, K. Luke, M. McLimont, M. Pai, M. C. Poon, V. Price, G. E. Rivard, S. Robinson, M. Steele, J. K. M. Wu, B. M. Feldman

AS-WE-004
3:15 - 3:30 PM
CONTRIBUTION OF POLYMORPHISMS IN THE IL-10, TNF-ALPHA, CTLA-4 GENES AND HLA CLASS II MOLECULES TO THE RISK OF INHIBITOR DEVELOPMENT: A CASE-CONTROL STUDY ON 260 PATIENTS WITH SEVERE HAEMOPHILIA A
A. Pavlova* (DE), D. Delev, M. Mende, R. Fimmers, R. Schwaab, J. Oldenburg

AS-WE-005
3:30 - 3:45 PM
TYPE OF FVIII PRODUCT AND INHIBITOR RISK IN PATIENTS WITH SEVERE HEMOPHILIA A AND NULL MUTATIONS IN THE FACTOR VIII GENE
E. Santagostino* (IT), M. E. Mancuso, A. Rocino, A. Tagliaferri, M. Margaglione, P. Mannucci

Chairperson: Shunichi Homma (US)

Paradoxical embolus and treatment of patent foramen ovale	AS-WE-006
Shunichi Homma (US)	2:15 - 2:45 PM

AS-WE-007
2:45 - 3:00 PM
YOUNG PATIENTS WITH STROKE, PFO (PATENT FORAMEN OVALE) AND THROMBOPHILIA
C. Lodigiani* (IT), D. Mari, P. Ferrazzi, M. Minaudo, L. Librè, E. Morenghi, L. L. Rota

AS-WE-008
3:00 - 3:15 PM
ANTIPHOSPHOLIPID ANTIBODIES AND THE RISK OF MYOCARDIAL INFARCTION AND ISCHEMIC STROKE IN YOUNG WOMEN
R. T. Urbanus* (NL), B. Siegerink, M. Roest, F. R. Rosendaal, P. G. de Groot, A. Algra

AS-WE-009
3:15 - 3:30 PM
ASSOCIATION OF COAGULATION AND INFLAMMATION RELATED GENES AND FACTOR 7 LEVELS WITH ISCHEMIC STROKE: THE CARDIOVASCULAR HEALTH STUDY
N. A. Zakai* (US), A. P. Reiner, L. A. Lang, W. T. Longstreth, E. O'Meara, J. Kelley, M. Fornage, D. A. Nickerson, M. Cushman

AS-WE-010 3:30 - 3:45 PM
POLYMORPHISMS ASSOCIATED WITH NONCARDIOEMBOLIC STROKE IN THREE CASE-CONTROL STUDIES
M. M. Luke, K. Berger, C. M. Rowland, J. J. Catanese, C. H. Tong, D. A. Ross, V. Garcia, C. R. Pullinger, M. J. Malloy, S. G. Ellis, J. P. Kane, J. J. Devlin, W. Lalouschek, C. Mannhalter* (AT)

Chairperson: Flora Peyvandi (IT)

Congenital and acquired TTP	AS-WE-011
Flora Peyvandi (IT)	2:15 -2:45 PM

AS-WE-012
2:45 - 3:00 PM
TTP AUTOANTIBODIES DEFINE A VWF BINDING SITE IN THE ADAMTS13 SPACER DOMAIN
B. M. Luken* (UK), W. Pos, J. Voorberg, J. T. B. Crawley, D. A. Lane

AS-WE-013
3:00 - 3:15 PM
RESIDUES ARG660, TYR661 AND TYR665 IN THE SPACER DOMAIN PROVIDE A COMMON ANTIGENIC CORE REQUIRED FOR BINDING OF ANTI-ADAMTS13 ANTIBODIES IN PATIENTS WITH ACQUIRED TTP
W. Pos* (NL), E. A. M. Turenhout, B. de Laat, R. Fijnheer, J. Voorberg

AS-WE-014
3:15 - 3:30 PM
SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS OF THE ANTI VON WILLEBRAND FACTOR APTAMER ARC1779 IN PATIENTS WITH ACUTE THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP)
B. Jilma, P. Jilma, J. C. Gilbert, R. Hutabarat, J. Siller, A. Spiel, M. Gorczyca, P. Knoebl* (AT)

AS-WE-015
3:30 - 3:45 PM
RECOMBINANT ADAMTS13 EFFICACY TO OVERWHELM INHIBITING ANTI-ADAMTS13 AUTOANTIBODY IN ACQUIRED TTP PATIENT PLASMA
B. Plaimauer* (AT), S. Skalicky, M. Hasslacher, M. Wolfsegger, F. Scheiflinger

Chairperson: Shosaku Nomura (JP)

New outlook on the clinical significance of microparticles	AS-WE-016
Shosaku Nomura (JP)	2:15 - 2:45 PM

AS-WE-017
2:45 - 3:00 PM
TISSUE FACTOR AND PROTEIN DISULFIDE ISOMERASE CO-LOCALIZE IN NON-CAVEOLAR RAFTS IN MICROPARTICLES
A. N. Böing* (NL), C. M. Hau, A. Sturk, R. Nieuwland

AS-WE-018
3:00 - 3:15 PM
PROTEOMIC ANALYSIS OF MICROPARTICLES/MICROVESICLES FROM HUMAN B (LG2) CELLS INFECTED WITH VIRUS
N. de Bosch, A. Becerra, K. J. Martin, M. Woda, K. J. Xhaja, I. Bosch* (US)

AS-WE-019
3:15 - 3:30 PM
THE DETECTION OF NANOSIZED BLOOD MICROPARTICLES BY ATOMIC FORCE MICROSCOPY
Y. Yuana* (NL), T. H. Oosterkamp, S. Bahatyrova, B. Ashcroft, P. Garcia Rodriguez, R. M. Bertina, S. Osanto

AS-WE-020
3:30 - 3:45 PM
LARGER VON WILLEBRAND FACTOR MULTIMERS PLAY A ROLE IN GENERATING PLATELET MICROPARTICLES
A. Artoni* (IT), A. Lecchi, M. Mancuso, E. Santagostino, A. B. Federici, P. Mannucci

Chairperson: Ananth Karumanchi (US)

Pathogenesis of pre-eclampsia	AS-WE-021
Ananth Karumanchi (US)	2:15 - 2:45 PM

AS-WE-022
2:45 - 3:00 PM
THE ASSOCIATION OF FVL AND PGM AND PLACENTA MEDIATED PREGNANCY COMPLICATIONS. A SYSTEMATIC REVIEW AND META-ANALYSIS OF PROSPECTIVE COHORT STUDIES
M. A. Rodger* (CA), M. Betancourt, M. Carrier

AS-WE-023
3:00 - 3:15 PM
LOW-MOLECULAR-WEIGHT HEPARIN FOR PREVENTION OF OBSTETRIC COMPLICATIONS IN CARRIERS OF FACTOR V LEIDEN OR PT-G20210A MUTATION
D. Tormene* (IT), E. Grandone, V. de Stefano, G. Palareti, G. Castaman, M. Margaglione, A. Ciminello, L. Valdre, A. Tosetto, P. Simioni

AS-WE-024
3:15 - 3:30 PM
INCREASED THROMBOXANE PRODUCTION IN PREECLAMPSIA - INFLUENCE OF ASPIRIN TREATMENT
C. Perneby* (SE), K. Bremme, M. Vahter, M. Daleskog, P. Hjemdahl

AS-WE-025 3:30 - 3:45 PM
SEARCH FOR AN ASSOCIATION BETWEEN V249I AND T280M CX3CR1 GENETIC POLYMORPHISMS, ENDOTHELIAL INJURY AND PREECLAMPSIA: THE ECLAXIR STUDY
A. Stepanian* (FR), S. Benchenni, T. Beillat-Lucas, S. Omnes, F. Defay, E. Peynaud-

Chairperson: John Hartwig (US)

Megakarycites and thrombopoiesis	AS-WE-026
John Hartwig (US)	2:15 - 2:45 PM

AS-WE-027
2:45 - 3:00 PM
LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN-1 (LRP1) IS TRANSIENTLY EXPRESSED DURING MEGAKARYOPOIESIS AND IS THE RECEPTOR BY WHICH PLATELET FACTOR 4 (PF4) INHIBITS MEGAKARYOCYTE DEVELOPMENT
M. P. Lambert* (US), Y. Wang, K. Bdeir, Y. Nguyen, M. A. Kowalska, M. Poncz

AS-WE-028
3:00 - 3:15 PM
ANUCLEATE PLATELETS GENERATE FUNCTIONAL PROGENY
H. Schwertz* (US), S. Koster, W. H. A. Kahr, L. W. Kraiss, G. A. Zimmerman, A. S. Weyrich

AS-WE-029
3:15 - 3:30 PM
ADF / N-COFILIN-DEPENDENT ACTIN TURNOVER IS ESSENTIAL FOR PLATELET FORMATION
M. Bender* (DE), M. Elvers, I. Pleines, C. Gurniak, G. Krohne, W. Witke, B. Nieswandt

AS-WE-030
3:30 - 3:45 PM
MEGAKARYOCYTE-SPECIFIC DELETION OF RAC1 AND CDC42 ABROGATES PROPLATELET FORMATION IN VITRO AND IN VIVO
I. Pleines* (DE), M. Elvers, M. Rhomdhane, A. Eckly, I. Hagedorn, M. Bender, X. Wu, A. Chrostek, G. Krohne, N. Debili, C. Gachet, C. Brakebusch, B. Nieswandt


Chairperson: Donna Woulfe (US)

Arrestin-2: Regulating platelet responses to agonist	AS-WE-031
Donna Woulfe (US)	2:15 -2:45 PM

AS-WE-032
2:45 - 3:00 PM
TWO DISTINCT PATHWAYS REGULATE PLATELET PHOSPHATIDYLSERINE EXPOSURE AND PROCOAGULANT FUNCTION
S. M. Schoenwaelder* (AU), Y. Yuan, E. C. Josefsson, M. J. White, E. Gardiner, R. Andrews, M. Hua, Y. Yao, K. D. Mason, L. A. O'Reilly, K. J. Henley, A. Ono, S. Hsiao, A. Willcox, A. W. Roberts, D. C. S. Huang, H. H. Salem, B. T. Kile, S. P. Jackson

AS-WE-033
3:00 - 3:15 PM
CRITICAL ROLE FOR CD148 IN HAEMOSTASIS AND PLATELET FORMATION IN VIVO
Y. A. Senis* (UK), M. G. Tomlinson, S. Ellison, A. Mazharian, Y. Zhao, N. Kalia, J. Zhu, A. Weiss, S. P. Watson

AS-WE-034
3:15 - 3:30 PM
PLATELET-POLYPHOSPHATES ARE PRO-COAGULANT AND PRO-INFLAMMATORY BY PLASMA CONTACT ACTIVATION IN VIVO
F. Mueller* (DE), N. J. Mutch Mueller, W. A. Schenk, W. A. Gahl, J. H. Morrissey, T. Renné

AS-WE-035
3:30 - 3:45 PM
CANONICAL WNT SIGNALLING IN PLATELETS NEGATIVELY REGULATES THEIR FUNCTION
B. M. Steele* (IE), I. C. Macaulay, M. T. Harper, R. Habas, A. Poole, D. J. Fitzgerald, P. B. Maguire


Chairperson: Zaverio Ruggeri (US)

Structure and function of von Willebrand factor: Facts and myths	AS-WE-036
Zaverio Ruggeri (US)	2:15 - 2:45 PM

AS-WE-037
2:45 - 3:00 PM
TRANSITION FROM LATENT TO ACTIVE CONFORMATION OF VON WILLEBRAND FACTOR OCCURS UPON EXOCYTOSIS
E. Groot* (NL), R. Fijnheer, S. Sebastian, P. J. Lenting, P. G. de Groot

AS-WE-038
3:00 - 3:15 PM
HOMOZYGOUS AND HETEROZYGOUS EXPRESSION OF TYPE 2A VON WILLEBRAND DISEASE (VWD) VARIANTS: NEGATIVE IMPACT ON MECHANISMS CRITICAL FOR VON WILLEBRAND FACTOR (VWF) PROCESSING AND SECRETION
P. M. Jacobi* (US), J. C. Gill, K. D. Friedman, R. R. Montgomery, S. L. Haberichter

AS-WE-039
3:15 - 3:30 PM
CELLULAR MODELS OF A DOMINANT-NEGATIVE VWF GENE DELETION: A BREAKPOINT SPECIFIC RNAI RESTORES SECRETION OF FUNCTIONAL VWF
C. Casari* (IT), M. Pinotti, A. Casonato, S. Calzavarini, D. Gemmati, F. Bernardi

AS-WE-040
3:30 - 3:45 PM
INTRACELLULAR STORAGE AND REGULATED SECRETION OF VON WILLEBRAND FACTOR IN QUANTITATIVE VON WILLEBRAND FACTOR DEFECTS
J. W. Wang* (NL), H. C. de Boer, K. M. Valentijn, R. J. Dirven, P. H. Reitsma, H. C. J. Eikenboom

Chairperson: Jacky Chi Ki Ngo (HK)

Crystal structure of B-domain deleted factor VIII and implications for the formation of the tenase complex	AS-WE-041
Jacky Chi Ki Ngo (HK)	2:15 - 2:45 PM

AS-WE-042
2:45 - 3:00 PM
LOSS OF FACTOR IX BINDING TO COLLAGEN IV RESULTS IN ABNORMAL IN VIVO HEMOSTASIS AND THROMBOSIS
P. E. Monahan* (US), T. Gui, A. Reheman, H. Ni, P. L. Gross, F. Yin, D. M. Monroe, D. W. Stafford

AS-WE-043
3:00 - 3:15 PM
INHIBITION OF MITOCHONDRIAL PERMEABILITY TRANSITION IMPROVES SECRETION OF COAGULATION FACTOR VIII
J. D. Malhotra* (US), H. Miao, S. W. Pipe, R. J. Kaufman

AS-WE-044
3:15 - 3:30 PM
HETEROGENEOUS LOCALIZATION OF COAGULATION FACTORS IN AN EX VIVO MODEL OF THROMBUS FORMATION
M. A. Berny* (US), I. C. A. Munnix, S. E. M. Schols, P. E. Bock, O. J. McCarty, J. W. M. Heemskerk

AS-WE-045
3:30 - 3:45 PM
IDENTIFICATION OF CRITICAL RESIDUES IN THE 558-LOOP OF FACTOR VIIIA A2 SUBUNIT IN THE INTERACTION WITH FACTOR IXA
I. Jagannathan* (US), H. Ichikawa, S. Chadha, T. Kruger, P. Fay

Chairperson: Katherine Hajjar (US)

Fibrinolysis and cellular functions: Implications for health and disease	AS-WE-046
Katherine Hajjar (US)	2:15 - 2:45 PM

AS-WE-047
2:45 - 3:00 PM
CRYSTAL STRUCTURES OF A SOLUBLE UROKINASE RECEPTOR MUTANT IN ITS LIGAND-FREE FORM AND IN COMPLEX WITH ITS LIGAND UPA
X. Xu* (US), H. Gårdsvoll, M. Ploug, M. Huang

AS-WE-048
3:00 - 3:15 PM
VISUALIZATION OF STRUCTURES EARLY IN FIBRIN POLYMERIZATION
I. N. Chernysh, C. Nagaswami, J. W. Weisel* (US)

AS-WE-049
3:15 - 3:30 PM
STRUCTURAL AND DYNAMIC PROPERTIES OF THE KRINGLE 2 DOMAIN OF HUMAN PLASMINOGEN IN COMPLEX WITH A PEPTIDE DERIVED FROM THE STREPTOCOCCAL SURFACE PROTEIN, PAM
M. Wang, J. Zajicek, M. Prorok* (US), F. J. Castellino

AS-WE-050
3:30 - 3:45 PM
ENDOTHELIAL MICROPARTICLES PLASMIN GENERATION: A NEW MECHANISM REGULATING ENDOTHELIUM PROTEOLYTIC ACTIVITIES
R. Lacroix* (FR), F. Sabatier, A. Mialhe, A. Basire, R. Pannell, H. Borghi, S. Robert, E. Lamy, L. Plawinski, L. Camoin-Jau, V. Gurewich, E. Angles-Cano, F. Dignat-George


Chairperson: Victoria Bautch (US)

Integrating cellular processes to make a blood vessel	AS-WE-051
Victoria Bautch (US)	2:15 - 2:45 PM

AS-WE-052
2:45 - 3:00 PM
MAKING ANTI-THROMBOTIC BYPASS VESSELS FROM SELECTED POPULATIONS OF VASCULAR SMOOTH MUSCLE CELLS
A. A. Dhanji* (UK), F. Y. Ali, L. S. Harrington, A. Shipolini, J. A. Mitchell, T. D. Warner

AS-WE-053
3:00 - 3:15 PM
CROSS-COUPLING OF THE TRANSCRIPTION FACTORS NF-E2 AND AP-1 REGULATES CELLAUTONOMOUSLY TROPHOBLAST SYNCYTIUM FORMATION AND PLACENTAL VASCULARISATION
M. Kashif, A. Hellweg, M. Thati, K. Shahzad, P. P. Nawroth, B. Isermann* (DE)

AS-WE-054
3:15 - 3:30 PM
THE GUT MICROBES TRIGGER SMALL INTESTINAL MICROVESSEL FORMATION VIA CYTOPLASMIC TAIL-DEPENDENT TISSUE FACTOR SIGNALING
C. Reinhardt* (SE), G. Östergren-Ludén, F. Schaffner, W. Ruf, F. Bäckhed

AS-WE-055
3:30 - 3:45 PM
TISSUE FACTOR PROMOTES AND STABILIZES THE VASCULAR PHENOTYPE OF NEWLY FORM CAPILLARIES
G. Arderiu, E. Peña, L. Badimon* (ES)


Chairperson: Timothy Hla (US)

Vascular cell signaling by sphingosine-1-phosphate: Implications for atherosclerosis	AS-WE-056
Timothy Hla (US)	2:15 - 2:45 PM

AS-WE-057
2:45 - 3:00 PM
ATHEROSCLEROSIS-ASSOCIATED LY-6CHI BLOOD MONOCYTOSIS IMPAIRS WOUND HEALING IN MICE WITH MYOCARDIAL INFARCTION
P. R. Panizzi* (US), F. K. Swirski, J. Figueiredo, P. Waterman, D. E. Sosnovik, E. Aikawa, P. Libby, M. Pittet, R. Weissleder, M. Nahrendorf

AS-WE-058
3:00 - 3:15 PM
GENETICALLY ALTERED LEVELS OF THROMBIN GENERATION DEMONSTRATE AN IMPACT ON ATHEROSCLEROTIC PROGRESSION IN APOE-NULL MICE
J. I. Borissoff* (NL), S. Heeneman, P. Leenders, R. van Oerle, H. Weiler, J. Degen, M. Marchetti, K. Hamulyák, M. Daemen, H. ten Cate, H. Spronk

AS-WE-059
3:15 - 3:30 PM
EVALUATION OF SPLA2 TYPE IIA AS A MARKER OF CORONARY ARTERY DISEASE AND ITS PREDICTIVE VALUE FOR FUTURE CORONARY EVENTS AMONG ASIAN INDIANS
V. S. Rao, B. K. Natesha, H. Sridhara, J. Shibu, V. V. Kakkar* (IN)

AS-WE-060
3:30 - 3:45 PM
ELEVATED FIBRINOGEN LEVELS AND SUBCLINICAL CARDIOVASCULAR DISEASE IN MIDDLEAGE: THE CARDIA STUDY
D. Green* (US), C. Chan, J. Kang, K. Liu, P. J. Schreiner, N. S. Jenny, R. P. Tracy